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The Paediatric obesity and cardiovascular risk research group is led by Dr. Abel López Bermejo since 2008. The research is aimed at identifying new metabolic, genetic, and epigenetic markers in early life stages (prenatal, perinatal, and early childhood) that indicate which infants are at greater risk of having cardiometabolic disorders and obesity in adulthood.

The research team leads multiple competitive research projects and oversees several doctoral and master's theses in this line of research. It has the collaboration of research, clinical and health care personnel at national and international levels. Multiple publications in international indexed journals are noteworthy in the group’s trajectory. In recent years, we have characterized several metabolic, genetic and epigenetic markers in relation to alterations in pre- and post-natal growth and metabolic dysfunction in school-age children.

Main lines of research

The group's main research line is the identification of markers in childhood for early prevention of cardiometabolic risk and obesity in adulthood.

The group's research lines below:

  • Prevention of obesity and cardiovascular risk in childhood.
    • Molecular bases / pathophysiology of childhood obesity.
    • Study of cardiovascular risk markers in childhood.

 

Study: Longitudinal clinical study in healthy pregnant-neonatal cohorts and prepuberal children from health centres in Girona.

Objective: To characterize new cardiometabolic risk markers in the paediatric age as well as to investigate possible mechanisms related to the onset of metabolic and cardiovascular disorders.

Methods: clinical, biochemical, imaging, and in vitro studies.

Financing: Consolidated line of research with FIS PI07 / 0404 and PI10 / 0053 projects.

 

  • Epigenetics of development.
    • Identification of the prenatal and postnatal bases of metabolic programming.
    • MicroRNAs study, DNA methylation and genetic imprinting.

 

Study:  Longitudinal clinical study in cohorts of healthy pregnant women included in the health areas of Girona and the Hospital Universitari de Girona Dr. Josep Trueta.

Objective:  Identifying epigenetic marks (microRNAs and DNA methylation) in the placenta and umbilical cord as new markers of susceptibility to metabolic diseases and cardiovascular risk. The studies involve both healthy new-borns and new-borns with alterations in prenatal development (maternal overnutrition or restriction of foetal growth) and also prepuberal children. The line also focuses on the study of genetic imprinting and the involvement of genes imprinted with a susceptibility to developing metabolic and cardiovascular diseases in adulthood.

Methods: Clinical, biochemical, imaging, and in vivo studies (  development of animal models for the analysis of epigenetic marks in metabolic regulation tissues -liver and adipose tissue- of offspring).

Financing: Consolidated line of research with FIS PI13/ 01257, PI13 / 01257 and PI19 / 00451 projects.

 

  • New technologies applied to health
    • Application and utility of new technologies for the monitoring of new-borns.

 

Study: Clinical study in neonates born at the Hospital Universitari de Girona Dr. Josep Trueta.

Objective: To develop smart systems for the health care of patients in order to provide health solutions in general, and specifically, for the monitoring of neonates at home.

Methods: Medical sensors and smartphones or low-cost smartphones coordinated telematically for health care.

Financing: Research line funded with the European ITEA2-ip11027 project; IPT-2012-0943-300000 INNPACTO.

 

  • Physiopathology and treatment of polycystic ovary syndrome (POS) in adolescents.

 

Study: clinical study in adolescents and young women with POS included in the Girona health area and the Hospital Universitari de Girona Dr. Josep Trueta.

Objective: To develop a new effective treatment for POS, a chronic endocrine-metabolic disorder often associated with obesity, based on the study of its pathophysiology. The study will focus on the reduction of hepatic and visceral fat mass in precocious stages of the disease in order to reduce the risk of cardiometabolic morbidity and anovulatory subfertility.

Methods: Clinical trial using medications with a metabolic and endocrine action and their combination, to reverse the POS phenotype.

Funding: Line of research funded with the European H2020-SC1-2020-two-stage-RTD SPIOMET4HEALTH 899671-2.

Strategic objectives

General:

  • Promote research in the area of paediatric endocrinology.
  • Design new disease prevention and patient assistance strategies.
  • Establish research collaborations with national and international groups for the main lines of research.

Specific:

  • Generating new advances in clinical research in paediatric obesity and cardiovascular risk.
  • Seek new epigenetic marks in early ages of life for identifying populations at risk of developing metabolic and cardiovascular disease in adulthood.
  • Identify new targets and therapeutic molecules in childhood obesity.
Publications

Garre-Olmo J, Turró-Garriga O, Martí-Lluch R, Zacarías-Pons L, Alves-Cabratosa L, Serrano-Sarbosa D, Vilalta-Franch J, Ramos R, Girona Healthy Region Study Group

Changes in lifestyle resulting from confinement due to COVID-19 and depressive symptomatology: A cross-sectional a population-based study.

COMPREHENSIVE PSYCHIATRY, 2021, 104, 152214-152214 dx.doi.org/10.1016/j.comppsych.2020.152214

Puig J, Biarnes C, Pedraza S, Vilanova JC, Pamplona R, Fernández-Real JM, Brugada R, Ramos R, Coll-De-Tuero G, Calvo-Perxas L, Serena J, Ramió-Torrentà L, Gich J, Gallart L, Portero-Otin M, Alberich-Bayarri A, Jimenez-Pastor A, Camacho-Ramos E, Mayneris-Perxachs J, Pineda V, Font R, Prats-Puig A, Gacto ML, Deco G, Escrichs A, Clotet B, Paredes R, Negredo E, Triaire B, Rodríguez M, Heredia-Escámez A, Coronado R, de Graaf W, Prevost V, Mitulescu A, Daunis-I-Estadella P, Thió-Henestrosa S, Miralles F, Ribas-Ripoll V, Puig-Domingo M, Essig M, Figley CR, Figley TD, Albensi B, Ashraf A, Reiber JHC, Schifitto G, Md Nasir U, Leiva-Salinas C, Wintermark M, Nael K, Vilalta-Franch J, Barretina J, Garre-Olmo J

The Aging Imageomics Study: rationale, design and baseline characteristics of the study population.

MECHANISMS OF AGEING AND DEVELOPMENT, 2020, 189, 111257-111257 dx.doi.org/10.1016/j.mad.2020.111257

Bassols J, Martínez-Calcerrada JM, Osiniri I, Díaz-Roldán F, Xargay-Torrent S, Mas-Parés B, Dorado-Ceballos E, Prats-Puig A, Carreras-Badosa G, de Zegher F, Ibáñez L, López-Bermejo A

Effects of metformin administration on endocrine-metabolic parameters, visceral adiposity and cardiovascular risk factors in children with obesity and risk markers for metabolic syndrome: A pilot study.

Plos One, 2019, 14, e0226303 dx.doi.org/10.1371/journal.pone.0226303

Mas-Parés B, Xargay-Torrent S, Bonmatí A, Lizarraga-Mollinedo E, Martínez-Calcerrada JM, Carreras-Badosa G, Prats-Puig A, de Zegher F, Ibáñez L, López-Bermejo A, Bassols J

Umbilical Cord miRNAs in Small-for-Gestational-Age Children and Association With Catch-Up Growth: A Pilot Study.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2019, 104, 5285-5298 dx.doi.org/10.1210/jc.2018-02346

Bassols J, Martínez-Calcerrada JM, Prats-Puig A, Carreras-Badosa G, Xargay-Torrent S, Lizarraga-Mollinedo E, Feliu-Alsina M, Riera-Pérez E, Osiniri I, de Zegher F, Ibáñez L, López-Bermejo A

Perirenal fat is related to carotid intima-media thickness in children.

INTERNATIONAL JOURNAL OF OBESITY, 2018, 42, 641-647 dx.doi.org/10.1038/ijo.2017.236

Carreras-Badosa G, Bonmatí A, Ortega FJ, Mercader JM, Guindo-Martínez M, Torrents D, Prats-Puig A, Martinez-Calcerrada JM, de Zegher F, Ibáñez L, Fernandez-Real JM, Lopez-Bermejo A, Bassols J

Dysregulation of Placental miRNA in Maternal Obesity Is Associated With Pre- and Postnatal Growth.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2017, 102, 2584-2594 dx.doi.org/10.1210/jc.2017-00089

Prats-Puig A, Moreno M, Carreras-Badosa G, Bassols J, Ricart W, López-Bermejo A, Fernández-Real JM

Serum Ferritin Relates to Carotid Intima-Media Thickness in Offspring of Fathers With Higher Serum Ferritin Levels.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2016, 36, 174-180 dx.doi.org/10.1161/ATVBAHA.115.306396

Bassols J, Moreno-Navarrete J, Carreras-Badosa G, Diaz M, Prats-Puig A, Palomer AM, de Zegher F, Ibáñez L, Fernandez-Real JM, Lopez-Bermejo A

Placental sprouty 2 (SPRY2): relation to placental growth and maternal metabolic status.

Neonatology, 2014, 106, 120-125 dx.doi.org/10.1159/000362783

López-Bermejo A, Ortega FJ, Castro A, Ricart W, Fernández-Real JM

The alarm secretory leukocyte protease inhibitor increases with progressive metabolic dysfunction

CLINICA CHIMICA ACTA, 2011, 412, 1122-1126 dx.doi.org/10.1016/j.cca.2011.02.037

Handberg A, Lopez-Bermejo A, Bassols J, Vendrell J, Ricart W, Fernandez-Real JM

Circulating soluble CD36 is associated with glucose metabolism and interleukin-6 in glucose-intolerant men

DIABETES & VASCULAR DISEASE RESEARCH, 2009, 6, 15-20 dx.doi.org/10.3132/dvdr.2009.003
Competitive projects
Codi oficial: Merck Salud Abel Start date:15/07/2019 Data fi: 14/07/2022 Investigador/a principal: ABEL LÓPEZ BERMEJO Organisme finançador: FUNDACION MERCK SALUD Ajuda: 30,000 €
Codi oficial: CD19/00172 Start date:01/01/2020 Data fi: 31/12/2022 Investigador/a principal: ABEL LÓPEZ BERMEJO Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 80,598 €
Codi oficial: FI20/00138 Start date:01/01/2021 Data fi: 31/12/2024 Investigador/a principal: ABEL LÓPEZ BERMEJO Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 82,400 €
Codi oficial: 2021 FI_B 000293 Start date:01/07/2021 Data fi: 30/06/2024 Investigador/a principal: ABEL LÓPEZ BERMEJO Organisme finançador: AGENCIA DE GESTIO D'AJUTS UNIV. I RECER. Ajuda: 66,600.75 €
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