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The Metabolic and Maternal-fetal research group is a multidisciplinary research group (basic researchers, clinicians, paediatricians and gynaecologists) that studies different metabolic and (epi)genetic markers associated with maternal and new-born metabolism for early identification of paediatric population at risk of developing metabolic diseases and obesity.

Main lines of research

Identification of metabolic and (epi)genetic markers associated with metabolic alterations in pregnancy and new-borns, and their relationship to pre- and post-natal growth.

Strategic objectives

The metabolic research group is characterized by extensive experience in both clinical and applied basic research, endorsed by competitive and overlapping funding from national and European research projects, as well as by publications in international journals in the field of the first quartile and decile in the line of energy metabolism from gestation to the paediatric age.

The group’s strategic objectives are below:

  • Cardiometabolic risk markers in the paediatric age
  • Metabolic programming during pregnancy
  • Epigenetics of development: miRNA and DNA methylation
  • Pathophysiological bases of low birth weight
  • Pharmacological reversibility of metabolic programming
  • New technologies applied to maternal and child health
Publications
Mas-Parés B, Xargay-Torrent S, Carreras-Badosa G, Gómez-Vilarrubla A, Niubó-Pallàs M, Tibau J, Reixach J, Prats-Puig A, de Zegher F, Ibañez L, Bassols J, López-Bermejo A

Gestational Caloric Restriction Alters Adipose Tissue Methylome and Offspring's Metabolic Profile in a Swine Model.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 dx.doi.org/10.3390/ijms25021128
Gómez-Vilarrubla A, Mas-Parés B, Carreras-Badosa G, Bonmatí-Santané A, Martínez-Calcerrada JM, Niubó-Pallàs M, de Zegher F, Ibáñez L, López-Bermejo A, Bassols J

DNA Methylation Signatures in Paired Placenta and Umbilical Cord Samples: Relationship with Maternal Pregestational Body Mass Index and Offspring Metabolic Outcomes.

Biomedicines, 2024, 12 dx.doi.org/10.3390/biomedicines12020301
Marzuillo P, Carreras-Badosa G, Martínez-Calcerrada JM, Guarino S, Palma PL, Petrone D, Miraglia Del Giudice E, Bassols J, López-Bermejo A

Body surface area-based kidney length percentiles misdiagnose small kidneys in children with overweight/obesity

PEDIATRIC NEPHROLOGY, 2023, 38, 1523-1532 dx.doi.org/10.1007/s00467-022-05718-8
Díaz M, Carreras-Badosa G, Villarroya J, Gavaldà-Navarro A, Bassols J, de Zegher F, López-Bermejo A, Villarroya F, Ibáñez L

Circulating GDF15 concentrations in girls with low birth weight: effects of prolonged metformin treatment

PEDIATRIC RESEARCH, 2023, 93, 964-968 dx.doi.org/10.1038/s41390-022-02175-9
Bassols J, de Zegher F, Diaz M, Carreras-Badosa G, Garcia-Beltran C, Puerto-Carranza E, Oliver-Vila C, Casano P, Franco CA, Malpique R, López-Bermejo A, Ibáñez L

Effects of half-dose spiomet treatment in girls with early puberty and accelerated bone maturation: a multicenter, randomized, placebo-controlled study protocol.

Trials, 2023, 24, 56-56 dx.doi.org/10.1186/s13063-022-07050-w
Carreras-Badosa G, Puerto-Carranza E, Mas-Parés B, Gómez-Vilarrubla A, Cebrià-Fondevila H, Díaz-Roldán F, Riera-Pérez E, de Zegher F, Ibañez L, Bassols J, López-Bermejo A

Circulating free T3 associates longitudinally with cardio-metabolic risk factors in euthyroid children with higher TSH.

Frontiers in Endocrinology, 2023, 14, 1172720-1172720 dx.doi.org/10.3389/fendo.2023.1172720
Suárez-Ortegón MF, Prats-Puig A, Bassols J, Carreras-Badosa G, McLachlan S, Wild SH, López-Bermejo A, Fernández-Real JM

Iron status and cardiometabolic risk in children.

DIABETES RESEARCH AND CLINICAL PRACTICE, 2023, 202, 110795-110795 dx.doi.org/10.1016/j.diabres.2023.110795
Gómez-Vilarrubla A, Mas-Parés B, Carreras-Badosa G, Xargay-Torrent S, Prats-Puig A, Bonmatí-Santané A, de Zegher F, Ibañez L, López-Bermejo A, Bassols J

Placental epigenetic marks related to gestational weight gain reveal potential genes associated with offspring obesity parameters.

Obesity, 2023, 31, 1903-1912 dx.doi.org/10.1002/oby.23780
Gómez-Vilarrubla A, Mas-Parés B, Carreras-Badosa G, Jové M, Berdún R, Bonmatí-Santané A, de Zegher F, Ibañez L, López-Bermejo A, Bassols J

Placental AA/EPA Ratio Is Associated with Obesity Risk Parameters in the Offspring at 6 Years of Age.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 dx.doi.org/10.3390/ijms241210087
Carreras-Badosa G, Remesar X, Prats-Puig A, Xargay-Torrent S, Lizarraga-Mollinedo E, de Zegher F, Ibáñez L, Bassols J, López-Bermejo A

Correction: Dlk1 expression relates to visceral fat expansion and insulin resistance in male and female rats with postnatal catch-up growth.

PEDIATRIC RESEARCH, 2023, 95, 406-406 dx.doi.org/10.1038/s41390-023-02691-2
Competitive projects
Codi oficial: PI20/00399 Start date:01/01/2021 Data fi: 31/12/2024 Investigador/a principal: JUDIT BASSOLS CASADEVALL Organisme finançador: INSTITUTO DE SALUD CARLOS III
Codi oficial: PI23/00545 Start date:01/01/2024 Data fi: 31/12/2024 Investigador/a principal: JUDIT BASSOLS CASADEVALL Organisme finançador: INSTITUTO DE SALUD CARLOS III
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