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The Metabolic and Maternal-fetal research group is a multidisciplinary research group (basic researchers, clinicians, paediatricians and gynaecologists) that studies different metabolic and (epi)genetic markers associated with maternal and new-born metabolism for early identification of paediatric population at risk of developing metabolic diseases and obesity.

Main lines of research

Identification of metabolic and (epi)genetic markers associated with metabolic alterations in pregnancy and new-borns, and their relationship to pre- and post-natal growth.

Strategic objectives

The metabolic research group is characterized by extensive experience in both clinical and applied basic research, endorsed by competitive and overlapping funding from national and European research projects, as well as by publications in international journals in the field of the first quartile and decile in the line of energy metabolism from gestation to the paediatric age.

The group’s strategic objectives are below:

  • Cardiometabolic risk markers in the paediatric age
  • Metabolic programming during pregnancy
  • Epigenetics of development: miRNA and DNA methylation
  • Pathophysiological bases of low birth weight
  • Pharmacological reversibility of metabolic programming
  • New technologies applied to maternal and child health
Publications
Carreras-Badosa G, Remesar X, Prats-Puig A, Xargay-Torrent S, Lizarraga-Mollinedo E, de Zegher F, Ibáñez L, Bassols J, López-Bermejo A

<i>Dlk1</i> expression relates to visceral fat expansion and insulin resistance in male and female rats with postnatal catch-up growth (vol 86, pg 195, 2019)

PEDIATRIC RESEARCH, 2024, 95, 406-406 dx.doi.org/10.1038/s41390-023-02691-2
Mas-Parés B, Xargay-Torrent S, Carreras-Badosa G, Gómez-Vilarrubla A, Niubó-Pallàs M, Tibau J, Reixach J, Prats-Puig A, de Zegher F, Ibañez L, Bassols J, López-Bermejo A

Gestational Caloric Restriction Alters Adipose Tissue Methylome and Offspring's Metabolic Profile in a Swine Model

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 dx.doi.org/10.3390/ijms25021128
Gómez-Vilarrubla A, Mas-Parés B, Carreras-Badosa G, Bonmatí-Santané A, Martínez-Calcerrada JM, Niubó-Pallàs M, de Zegher F, Ibáñez L, López-Bermejo A, Bassols J

DNA Methylation Signatures in Paired Placenta and Umbilical Cord Samples: Relationship with Maternal Pregestational Body Mass Index and Offspring Metabolic Outcomes

Biomedicines, 2024, 12 dx.doi.org/10.3390/biomedicines12020301
Osinga JAJ, Liu Y, Männistö T, Vafeiadi M, Tao FB, Vaidya B, Vrijkotte TGM, Mosso L, Bassols J, López-Bermejo A, Boucai L, Aminorroaya A, Feldt-Rasmussen U, Hisada A, Yoshinaga J, Broeren MAC, Itoh S, Kishi R, Ashoor G, Chen L, Veltri F, Lu X, Taylor PN, Brown SJ, Chatzi L, Popova PV, Grineva EN, Ghafoor F, Pirzada A, Kianpour M, Oken E, Suvanto E, Hattersley A, Rebagliato M, Riaño-Galán I, Irizar A, Vrijheid M, Delgado-Saborit JM, Fernández-Somoano A, Santa-Marina L, Boelaert K, Brenta G, Dhillon-Smith R, Dosiou C, Eaton JL, Guan H, Lee SY, Maraka S, Morris-Wiseman LF, Nguyen CT, Shan Z, Guxens M, Pop VJM, Walsh JP, Nicolaides KH, D'Alton ME, Visser WE, Carty DM, Delles C, Nelson SM, Alexander EK, Chaker L, Palomaki GE, Peeters RP, Bliddal S, Huang K, Poppe KG, Pearce EN, Derakhshan A, Korevaar TIM

Risk Factors for Thyroid Dysfunction in Pregnancy: An Individual Participant Data Meta-Analysis

Thyroid, 2024, 34, 646-658 dx.doi.org/10.1089/thy.2023.0646
Martínez-Diago, C, Mademont-Soler, I, Bonmati, A, Rodo, C, Alberch, A, Obon, M, Fuertes, B, Maroto, A

Novel variant in <i>ACTA1</i> identified in a fetus with akinesia deformation sequence and cortical development delay

PRENATAL DIAGNOSIS, 2024, 44, 996-998 dx.doi.org/10.1002/pd.6568
Bonmatí-Santané, A, López, RC, Saltos, JJA, Martínez, JC, Paez, CN, Sánchez, JP, Figueredo, NV, González, AM

Managing a Pregnancy in the Presence of the Rare Blood Group Antibody PP1Pk

Womens Health Reports, 2024, 5, 319-323 dx.doi.org/10.1089/whr.2023.0120
Vasileva, F, Carreras-Badosa, G, Bassols, J, Serrano-Ferrer, J, Font-Lladó, R, López-Ros, V, Osiniri, I, Martínez-Calcerrada, JM, San Millán, M, López-Bermejo, A, Prats-Puig, A

Insulin resistance, C-reactive protein, diastolic to systolic blood pressure ratio and epicardial fat are related to sedentary time, and inversely related to physical activity in school-aged children

Frontiers in Public Health, 2024, 12 dx.doi.org/10.3389/fpubh.2024.1339860
Marzuillo P, Carreras-Badosa G, Martínez-Calcerrada JM, Guarino S, Palma PL, Petrone D, Miraglia Del Giudice E, Bassols J, López-Bermejo A

Body surface area-based kidney length percentiles misdiagnose small kidneys in children with overweight/obesity

PEDIATRIC NEPHROLOGY, 2023, 38, 1523-1532 dx.doi.org/10.1007/s00467-022-05718-8
Díaz M, Carreras-Badosa G, Villarroya J, Gavaldà-Navarro A, Bassols J, de Zegher F, López-Bermejo A, Villarroya F, Ibáñez L

Circulating GDF15 concentrations in girls with low birth weight: effects of prolonged metformin treatment

PEDIATRIC RESEARCH, 2023, 93, 964-968 dx.doi.org/10.1038/s41390-022-02175-9
Bassols J, de Zegher F, Diaz M, Carreras-Badosa G, Garcia-Beltran C, Puerto-Carranza E, Oliver-Vila C, Casano P, Franco CA, Malpique R, López-Bermejo A, Ibáñez L

Effects of half-dose spiomet treatment in girls with early puberty and accelerated bone maturation: a multicenter, randomized, placebo-controlled study protocol

Trials, 2023, 24, 56-56 dx.doi.org/10.1186/s13063-022-07050-w
Competitive projects
Codi oficial: PI20/00399 Start date:01/01/2021 Data fi: 31/12/2024 Investigador/a principal: JUDIT BASSOLS CASADEVALL Organisme finançador: INSTITUTO DE SALUD CARLOS III
Codi oficial: PI23/00545 Start date:01/01/2024 Data fi: 31/12/2024 Investigador/a principal: JUDIT BASSOLS CASADEVALL Organisme finançador: INSTITUTO DE SALUD CARLOS III
Codi oficial: NUTRIENTS_2024_AGV Start date:26/03/2024 Data fi: 31/12/2024 Investigador/a principal: ARIADNA GÓMEZ VILARRUBLA Organisme finançador: MDPI AG
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