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The Metabolic Maternal-Fetal Research Group is a multidisciplinary group (basic and clinical research staff in pediatrics and gynecology) that studies several metabolic and epigenetic markers associated with pre and postnatal development in order to identify the pediatric population at risk of developing metabolic diseases.

The group is characterized by extensive experience in both clinical and basic applied research, supported by competitive and overlapping funding of National and European research projects, as well as by publications in international journals of the first quartile and decile in the line of energy metabolism from gestation to the pediatric age.

Main lines of research

Main line of research:

  • Fetal metabolic programming and its impact on the child's health

Specific lines of research:

  • Metabolic programming and low birth weight:
    • Study new biomarkers to identify small-for-gestational-age (SGA) newborns that will show postnatal catch-up growth
    • Determine the effect of metformin on recuperative growth.
  • Epigenetics and metabolic programming of childhood obesity:
    • Study the influence of placental fatty acids as predictors of childhood obesity.
    • Identify epigenetic marks (miRNA and DNA methylation) during gestation (maternal plasma, placenta and umbilical cord) as predictors of childhood obesity.
Strategic objectives
  • Generate new knowledge about the pathophysiology of low birth weight
  • Study the mechanisms involved in metabolic programming during pregnancy
  • Describe new biomarkers that may be useful to identify the pediatric population susceptible to developing metabolic problems and obesity
  • Develop new technologies applied to maternal and child health
Publications
Mas-Parés B, Carreras-Badosa G, Gómez-Vilarrubla A, De Arriba-Muñoz A, Lafalla-Bernard O, Prats-Puig A, De Zegher F, Ibañez L, Haqq AM, Bassols J, Lopez-Bermejo A

Sex dimorphic associations of Prader-Willi imprinted gene expressions in umbilical cord with prenatal and postnatal growth in healthy infants.

WORLD JOURNAL OF PEDIATRICS, 2025, 21, 100-112 dx.doi.org/10.1007/s12519-024-00865-4
Gómez-Vilarrubla, A, Niubó-Pallàs, M, Mas-Parés, B, Bonmati-Santané, A, Martínez-Calcerrada, JM, López, B, Peñas-Cruz, A, de Zegher, F, Ibáñez, L, López-Bermejo, A, Bassols, J

Longitudinal Analysis of Placental IRS1 DNA Methylation and Childhood Obesity

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2025, 26 dx.doi.org/10.3390/ijms26073141
Casellas A, Martínez C, Amigó J, Ferrer R, Martí L, Merced C, Medina MC, Molinero I, Calveiro M, Maroto A, Del Barco E, Carreras E, Goya M

Evaluation of an Alternative Screening Method for Gestational Diabetes Diagnosis During the COVID-19 Pandemic (DIABECOVID STUDY): An Observational Cohort Study.

Diagnostics, 2025, 15 dx.doi.org/10.3390/diagnostics15020189
Garcia-Manau P, Bonacina E, Martin-Alonso R, Martin L, Palacios A, Sanchez-Camps ML, Lesmes C, Hurtado I, Perez E, Tubau A, Ibañez P, Alcoz M, Valiño N, Moreno E, Borrero C, Garcia E, Lopez-Quesada E, Diaz S, Broullon JR, Teixidor M, Chulilla C, Ferrer-Costa R, Gil MM, Lopez M, Ramos-Forner GM, Blanco JE, Moreno A, Lázaro-Rodríguez M, Vaquerizo O, Soriano B, Fabre M, Gomez-Valencia E, Cuiña A, Alayon N, Sainz-Bueno JA, Vives A, Esteve E, Ocaña V, López MÁ, Maroto A, Carreras E, Mendoza M

Angiogenic factors versus fetomaternal Doppler for fetal growth restriction at term: an open-label, randomized controlled trial.

NATURE MEDICINE, 2025, 31, 1008-1015 dx.doi.org/10.1038/s41591-024-03421-9
Carreras-Badosa G, Remesar X, Prats-Puig A, Xargay-Torrent S, Lizarraga-Mollinedo E, de Zegher F, Ibáñez L, Bassols J, López-Bermejo A

<i>Dlk1</i> expression relates to visceral fat expansion and insulin resistance in male and female rats with postnatal catch-up growth (vol 86, pg 195, 2019)

PEDIATRIC RESEARCH, 2024, 95, 406-406 dx.doi.org/10.1038/s41390-023-02691-2
Mas-Parés B, Xargay-Torrent S, Carreras-Badosa G, Gómez-Vilarrubla A, Niubó-Pallàs M, Tibau J, Reixach J, Prats-Puig A, de Zegher F, Ibañez L, Bassols J, López-Bermejo A

Gestational Caloric Restriction Alters Adipose Tissue Methylome and Offspring's Metabolic Profile in a Swine Model

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 dx.doi.org/10.3390/ijms25021128
Gómez-Vilarrubla A, Mas-Parés B, Carreras-Badosa G, Bonmatí-Santané A, Martínez-Calcerrada JM, Niubó-Pallàs M, de Zegher F, Ibáñez L, López-Bermejo A, Bassols J

DNA Methylation Signatures in Paired Placenta and Umbilical Cord Samples: Relationship with Maternal Pregestational Body Mass Index and Offspring Metabolic Outcomes

Biomedicines, 2024, 12 dx.doi.org/10.3390/biomedicines12020301
Osinga JAJ, Liu Y, Männistö T, Vafeiadi M, Tao FB, Vaidya B, Vrijkotte TGM, Mosso L, Bassols J, López-Bermejo A, Boucai L, Aminorroaya A, Feldt-Rasmussen U, Hisada A, Yoshinaga J, Broeren MAC, Itoh S, Kishi R, Ashoor G, Chen L, Veltri F, Lu X, Taylor PN, Brown SJ, Chatzi L, Popova PV, Grineva EN, Ghafoor F, Pirzada A, Kianpour M, Oken E, Suvanto E, Hattersley A, Rebagliato M, Riaño-Galán I, Irizar A, Vrijheid M, Delgado-Saborit JM, Fernández-Somoano A, Santa-Marina L, Boelaert K, Brenta G, Dhillon-Smith R, Dosiou C, Eaton JL, Guan H, Lee SY, Maraka S, Morris-Wiseman LF, Nguyen CT, Shan Z, Guxens M, Pop VJM, Walsh JP, Nicolaides KH, D'Alton ME, Visser WE, Carty DM, Delles C, Nelson SM, Alexander EK, Chaker L, Palomaki GE, Peeters RP, Bliddal S, Huang K, Poppe KG, Pearce EN, Derakhshan A, Korevaar TIM

Risk Factors for Thyroid Dysfunction in Pregnancy: An Individual Participant Data Meta-Analysis

Thyroid, 2024, 34, 646-658 dx.doi.org/10.1089/thy.2023.0646
Martínez-Diago, C, Mademont-Soler, I, Bonmati, A, Rodo, C, Alberch, A, Obon, M, Fuertes, B, Maroto, A

Novel variant in <i>ACTA1</i> identified in a fetus with akinesia deformation sequence and cortical development delay

PRENATAL DIAGNOSIS, 2024, 44, 996-998 dx.doi.org/10.1002/pd.6568
Bonmatí-Santané, A, López, RC, Saltos, JJA, Martínez, JC, Paez, CN, Sánchez, JP, Figueredo, NV, González, AM

Managing a Pregnancy in the Presence of the Rare Blood Group Antibody PP1Pk

Womens Health Reports, 2024, 5, 319-323 dx.doi.org/10.1089/whr.2023.0120
Competitive projects
Metabolic and Maternal-fetal

Inteligencia artificial, epigenética y predicción de la obesidad infantil

Codi oficial: IA, epigenetica y predicción de la obesidad infantil Start date:01/06/2022 Data fi: 31/12/2025 Investigador/a principal: JUDIT BASSOLS CASADEVALL Organisme finançador: SOCIEDAD ESPAÑOLA DE ENDOCRINOLOGÍA PEDIÁTRICA (SEEP)
Metabolic and Maternal-fetal

Estudio de marcas epigenéticas relacionadas con la obesidad en trios madre-padre-hijo: transmisión parental e influencia ambiental

Codi oficial: PI23/00545 Start date:01/01/2024 Data fi: 31/12/2026 Investigador/a principal: JUDIT BASSOLS CASADEVALL Organisme finançador: INSTITUTO DE SALUD CARLOS III
Metabolic and Maternal-fetal

Ayuda de personal PFIS

Codi oficial: FI24/00165 Start date:08/01/2025 Data fi: 07/01/2029 Investigador/a principal: JUDIT BASSOLS CASADEVALL, MARIA NIUBÓ PALLÀS Organisme finançador: INSTITUTO DE SALUD CARLOS III
Metabolic and Maternal-fetal

L’expressió dels miRNA leucocitaris com a nous biomarcadors de la obesitat infantil

Codi oficial: 2023_ACMG_JBC Start date:23/05/2024 Data fi: 22/05/2026 Investigador/a principal: JUDIT BASSOLS CASADEVALL Organisme finançador: FUNDACIÓ ACADÈMIA CIÈNCIES MÈDIQUES
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