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The Precision Oncology research group in Girona (OncoGiR_Pro) is made up of researchers who are members of the ICO Girona Medical Oncology Service and collaborators from other services, located at the Hospital Dr. Josep Trueta. Led by Dr. Joaquim Bosch, the research group's mission is to integrate clinical, epidemiological and translational research in the field of precision oncology. The aim is to develop new therapeutic strategies and identify biomarkers for predicting the risk and clinical course of various cancers.

Main lines of research
  • Clinical development of new drugs, biomarkers for predicting response to treatment and clinical evolution, genetic basis of hereditary cancer, cancer risk prediction models.

These lines of research apply to different tumours: breast, digestive, thoracic, urological, skin, ENT and gynaecological.

Strategic objectives
  • Mission: To integrate clinical, epidemiological and translational research in the field of precision oncology.
  • Goal: To develop new therapeutic strategies and identify biomarkers for the prediction of risk and clinical evolution of different cancers.
Publications
Slomovitz BM, Cibula D, Lv W, Ortaç F, Hietanen S, Backes F, Kikuchi A, Lorusso D, Danska-Bidzinska A, Samouëlian V, Barretina-Ginesta MP, Vulsteke C, Lai CH, Pothuri B, Zhang Y, Magallanes-Maciel M, Amit A, Guarneri V, Zagouri F, Bell M, Welz J, Eminowicz G, Hruda M, J Willmott L, Lichfield J, Wang W, Orlowski R, Aktan G, Gladieff L, Van Gorp T

Pembrolizumab or Placebo Plus Adjuvant Chemotherapy With or Without Radiotherapy For Newly Diagnosed, High-Risk Endometrial Cancer: Results in Mismatch Repair-Deficient Tumors.

JOURNAL OF CLINICAL ONCOLOGY, 2025, 43, 251-259 dx.doi.org/10.1200/JCO-24-01887
Graybill WS, Vergote I, Pothuri B, Anttila M, O'Malley DM, Lorusso D, Haggerty AF, Fabbro M, Chan JK, Heitz F, Willmott LJ, Bruchim I, Zhuo Y, Estévez-García P, Monk BJ, Denys H, Knudsen A, Tinker AV, Sánchez LM, Provencher D, Barretina-Ginesta MP, Hartman J, Booth DV, González-Martín A

Use of individualized starting dose and niraparib hematologic adverse event management costs in ovarian cancer.

JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH, 2025, 14 dx.doi.org/10.57264/cer-2024-0133
Mirza MR, Bjørge L, Marmé F, Christensen RD, Gil-Martin M, Auranen A, Ataseven B, Rubio MJ, Salutari V, Luczak AA, Runnebaum IB, Redondo A, Lindemann K, Trillsch F, Ginesta MPB, Roed H, Kurtz JE, Petersson KS, Nyvang GB, Sehouli J

Palbociclib plus letrozole in estrogen receptor-positive advanced/recurrent endometrial cancer: Double-blind placebo-controlled randomized phase II ENGOT-EN3/PALEO trial.

GYNECOLOGIC ONCOLOGY, 2025, 192, 128-136 dx.doi.org/10.1016/j.ygyno.2024.12.003
Rofes, P, Castillo-Manzano, C, Menéndez, M, Teulé, A, Iglesias, S, Munté, E, Ramos-Muntada, M, Gómez, C, Tornero, E, Darder, E, Montes, E, Valle, L, Capellá, G, Pineda, M, Brunet, J, Feliubadaló, L, del Valle, J, Lázaro, C

<i>TP53</i> germline testing and hereditary cancer: how somatic events and clinical criteria affect variant detection rate

GENOME MEDICINE, 2025, 17, 3-3 dx.doi.org/10.1186/s13073-025-01429-5
Navarro-Sabaté, A, Font, R, Espinas, JA, Solà, J, Martínez-Soler, F, Gil-Gil, M, Viñas, G, Tibau, A, Borrell, M, Segui, M, Margelí, M, Servitja, S, Perez, C, Domenech, M, Nava, M, Marin, M, Gonzalez, S, Borràs, JM

Evaluating the Quality of Real-World Data on Adherence to Oral Endocrine Therapy in Breast Cancer Patients: How Real Is Real-World Data?

Cancers, 2025, 17 dx.doi.org/10.3390/cancers17020200
Tavira B, Iscar T, Manso L, Santaballa A, Gil-Martin M, García García Y, Romeo M, Iglesias M, de Juan Ferré A, Barretina-Ginesta MP, Manzano A, Gaba L, Rubio MJ, de Andrea CE, González-Martín A

Analysis of tumor microenvironment changes after neoadjuvant chemotherapy with or without bevacizumab in advanced ovarian cancer (GEICO-89T/MINOVA study).

CLINICAL CANCER RESEARCH, 2024, 30, 176-186 dx.doi.org/10.1158/1078-0432.CCR-23-0771
Fernández-Castillejo S, Roig B, Melé M, Serrano S, Salvat M, Querol M, Brunet J, Pineda M, Cisneros A, Parada D, Badia J, Borràs J, Rodríguez-Balada M, Gumà J

Opportunistic genetic screening increases the diagnostic yield and is medically valuable for care of patients and their relatives with hereditary cancer

JOURNAL OF MEDICAL GENETICS, 2024, 61, 69-77 dx.doi.org/10.1136/jmg-2023-109389
Gonzalez-Abuin N, Pons T, Fuster T, Quintana I, Terradas M, Aiza G, Brunet J, Capellá G, Hampel H, Valle L

Lack of evidence for germline <i>WWP1</i> pathogenic variants in gastrointestinal polyposis and other phenotypes suggestive of PTEN-hamartoma-tumor syndrome

GENES & DISEASES, 2024, 11, 524-527 dx.doi.org/10.1016/j.gendis.2023.03.011
Mostaghim A, Minkove S, Aguilar-Company J, Ruiz-Camps I, Eremiev-Eremiev S, Dettorre GM, Fox L, Tondini C, Brunet J, Carmona-García M, Lambertini M, Bower M, Newsom-Davis T, Sharkey R, Pria AD, Rossi M, Plaja A, Salazar R, Sureda A, Prat A, Michalarea V, Van Hemelrijck M, Sita-Lumsden A, Bertuzzi A, Rimassa L, Rossi S, Rizzo G, Pedrazzoli P, Lee AJ, Murphy C, Belessiotis K, Diamantis N, Mukherjee U, Pommeret F, Stoclin A, Martinez-Vila C, Bruna R, Gaidano G, D'Avanzo F, Gennari A, Athale J, Eichacker P, Pinato DJ, Torabi-Parizi P, Cortellini A

Previous immune checkpoint inhibitor therapy is associated with decreased COVID-19-related hospitalizations and complications in patients with cancer: Results of a propensity-matched analysis of the OnCovid registry

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2024, 139, 13-20 dx.doi.org/10.1016/j.ijid.2023.11.021
Riudavets M, Auclin E, Mosteiro M, Dempsey N, Majem M, Prelaj A, López-Castro R, Bosch-Barrera J, Pilotto S, Escalera E, Tagliamento M, Mosquera J, Zalcman G, Aboubakar Nana F, Ponce S, Albarrán-Artahona V, Dal Maso A, Spotti M, Mielgo X, Mussat E, Reyes R, Benítez JC, Lupinacci L, Duchemann B, De Giglio A, Blaquier JB, Audigier-Valette C, Scheffler M, Nadal E, Lopes G, Signorelli D, Garcia-Campelo R, Menis J, Bluthgen V, Campayo M, Recondo G, Besse B, Mezquita L, Planchard D

Association Between Lung Immune Prognostic Index and Durvalumab Consolidation Outcomes in Patients With Locally Advanced Non-Small-Cell Lung Cancer.

CLINICAL LUNG CANCER, 2024, 25 dx.doi.org/10.1016/j.cllc.2023.11.007
Competitive projects
Precision Oncology in Girona

Y-RNAs AS NON-INVASIVE BIOMARKERS FOR EARLY CANCER DETECTION

Codi oficial: IDEAS246813BRUN Start date:01/12/2024 Data fi: 30/11/2026 Investigador/a principal: JOAN BRUNET VIDAL Organisme finançador: ASSOCIACIÓ ESPANYOLA CONTRA EL CÀNCER
Precision Oncology in Girona

CarboSign7 for cancer diagnosis: Biosampling optimization and validation for gastric and lung cancer

Codi oficial: CI23-20369 Start date:30/10/2023 Data fi: 30/10/2025 Investigador/a principal: ADELAIDA GARCIA VELASCO Organisme finançador: FUNDACIÓN BANCARIA LA CAIXA
Precision Oncology in Girona

CANCER PREVENTION VS CANCER TREATMENT: THE RARE TUMOUR RISK SYNDROMES BATTLE

Codi oficial: 101095483 Start date:01/01/2023 Data fi: 31/12/2025 Investigador/a principal: JOAN BRUNET VIDAL Organisme finançador: EUROPEAN COMISSION
Precision Oncology in Girona

Premio mejor póster SEOM2024 con el título “Efecto del ritmo circadiano inmunológico en el tratamiento del cáncer de pulmón de célula no pequeña localmente avanzado tratado con inmunoterapia de consolidación”.

Codi oficial: Premio mejor póster SEOM2024 Start date:01/01/2025 Data fi: 31/12/2025 Investigador/a principal: ELISABET BUJONS BUSCARONS, ESTER OLIVA POCH Organisme finançador: SOCIEDAD ESPAÑOLA DE ONCOLOGÍA MÉDICA (SEOM)
Precision Oncology in Girona

Evaluación de un nuevo biomarcador pan-cáncer para mejorar la predicción de respuesta a inmunoterapia.

Codi oficial: biomarcador pan-cáncer Start date:19/10/2020 Data fi: 01/12/2025 Investigador/a principal: JOAN BRUNET VIDAL Organisme finançador: SOCIEDAD ESPAÑOLA DE ONCOLOGÍA MÉDICA (SEOM)
Precision Oncology in Girona

Validación de la utilidad clínica de la evaluación de la inestabilidad de microsatélites con alta sensibilidad en la mejora del diagnóstico precoz de cáncer de endometrio y en el establecimiento de estrategias de seguimiento ginecológico personalizadas en síndrome de Lynch (PROJECTES)

Codi oficial: Inestabilidad de microsatélites con alta sensibilidad Start date:01/05/2023 Data fi: 27/04/2025 Investigador/a principal: JOAN BRUNET VIDAL Organisme finançador: SOCIEDAD ESPAÑOLA DE ONCOLOGÍA MÉDICA (SEOM)
Precision Oncology in Girona

A therapeutic strategy to co-target brain metastasis-initiating and hyperlipidemia-driving mechanisms in lorlatinib-treated NSCLC

Codi oficial: Pfizer 2019 Joaquim Bosch Start date:05/07/2019 Data fi: 31/12/2025 Investigador/a principal: JOAQUIM BOSCH BARRERA, JAVIER ABEL MENÉNDEZ MENÉNDEZ Organisme finançador: PFIZER, S.L.U.
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