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The Precision Oncology research group in Girona (OncoGiR_Pro) is made up of researchers who are members of the ICO Girona Medical Oncology Service and collaborators from other services, located at the Hospital Dr. Josep Trueta. Led by Dr. Joaquim Bosch, the research group's mission is to integrate clinical, epidemiological and translational research in the field of precision oncology. The aim is to develop new therapeutic strategies and identify biomarkers for predicting the risk and clinical course of various cancers.

Main lines of research
  • Clinical development of new drugs, biomarkers for predicting response to treatment and clinical evolution, genetic basis of hereditary cancer, cancer risk prediction models.

These lines of research apply to different tumours: breast, digestive, thoracic, urological, skin, ENT and gynaecological.

Strategic objectives
  • Mission: To integrate clinical, epidemiological and translational research in the field of precision oncology.
  • Goal: To develop new therapeutic strategies and identify biomarkers for the prediction of risk and clinical evolution of different cancers.
Publications
Slomovitz BM, Cibula D, Lv W, Ortaç F, Hietanen S, Backes F, Kikuchi A, Lorusso D, Danska-Bidzinska A, Samouëlian V, Barretina-Ginesta MP, Vulsteke C, Lai CH, Pothuri B, Zhang Y, Magallanes-Maciel M, Amit A, Guarneri V, Zagouri F, Bell M, Welz J, Eminowicz G, Hruda M, J Willmott L, Lichfield J, Wang W, Orlowski R, Aktan G, Gladieff L, Van Gorp T

Pembrolizumab or Placebo Plus Adjuvant Chemotherapy With or Without Radiotherapy For Newly Diagnosed, High-Risk Endometrial Cancer: Results in Mismatch Repair-Deficient Tumors.

JOURNAL OF CLINICAL ONCOLOGY, 2025, 43, 251-259 dx.doi.org/10.1200/JCO-24-01887
Graybill WS, Vergote I, Pothuri B, Anttila M, O'Malley DM, Lorusso D, Haggerty AF, Fabbro M, Chan JK, Heitz F, Willmott LJ, Bruchim I, Zhuo Y, Estévez-García P, Monk BJ, Denys H, Knudsen A, Tinker AV, Sánchez LM, Provencher D, Barretina-Ginesta MP, Hartman J, Booth DV, González-Martín A

Use of individualized starting dose and niraparib hematologic adverse event management costs in ovarian cancer.

JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH, 2025, 14 dx.doi.org/10.57264/cer-2024-0133
Mirza MR, Bjørge L, Marmé F, Christensen RD, Gil-Martin M, Auranen A, Ataseven B, Rubio MJ, Salutari V, Luczak AA, Runnebaum IB, Redondo A, Lindemann K, Trillsch F, Ginesta MPB, Roed H, Kurtz JE, Petersson KS, Nyvang GB, Sehouli J

Palbociclib plus letrozole in estrogen receptor-positive advanced/recurrent endometrial cancer: Double-blind placebo-controlled randomized phase II ENGOT-EN3/PALEO trial.

GYNECOLOGIC ONCOLOGY, 2025, 192, 128-136 dx.doi.org/10.1016/j.ygyno.2024.12.003
Rofes, P, Castillo-Manzano, C, Menéndez, M, Teulé, A, Iglesias, S, Munté, E, Ramos-Muntada, M, Gómez, C, Tornero, E, Darder, E, Montes, E, Valle, L, Capellá, G, Pineda, M, Brunet, J, Feliubadaló, L, del Valle, J, Lázaro, C

<i>TP53</i> germline testing and hereditary cancer: how somatic events and clinical criteria affect variant detection rate

GENOME MEDICINE, 2025, 17, 3-3 dx.doi.org/10.1186/s13073-025-01429-5
Navarro-Sabaté, A, Font, R, Espinas, JA, Solà, J, Martínez-Soler, F, Gil-Gil, M, Viñas, G, Tibau, A, Borrell, M, Segui, M, Margelí, M, Servitja, S, Perez, C, Domenech, M, Nava, M, Marin, M, Gonzalez, S, Borràs, JM

Evaluating the Quality of Real-World Data on Adherence to Oral Endocrine Therapy in Breast Cancer Patients: How Real Is Real-World Data?

Cancers, 2025, 17 dx.doi.org/10.3390/cancers17020200
Rubio-Casadevall, J, Trallero, J, Calvo, C, Puigdemont, M, Carulla, M, Sanvisens, A, Ameijide, A, Vidal, A, Pla, C, Marruecos, J, Marcos-Gragera, R, Galceran, J

A population-based study of incidence trends of head and neck epithelial cancers in northeastern Spain, 1994-2018

CLINICAL & TRANSLATIONAL ONCOLOGY, 2025 dx.doi.org/10.1007/s12094-025-03855-8
Bosch-Barrera J, Estévez-García P, Martín-Martorell P, Sabatier R, Nadal E, Sais E, Gascón P, Oaknin A, Rodon J, Lizcano JM, Muñoz-Guardiola P, Fierro-Durán G, Pedrós-Gámez O, Pérez-Montoyo H, Yeste-Velasco M, Cortal M, Pérez-Campos A, Alfón J, Domènech C, Morán T

ENDOLUNG trial, part II. A phase II study of the Akt/mTOR inhibitor and autophagy inducer ibrilatazar (ABTL0812) in combination with paclitaxel/carboplatin in patients with squamous non-small cell lung cancer.

LUNG CANCER, 2025, 201, 108105-108105 dx.doi.org/10.1016/j.lungcan.2025.108105
Indini A, Didoné F, Massi D, Puig S, Casadevall JR, Bennett D, Katalinic A, Sanvisens A, Ferrari A, Lasalvia P, Demuru E, Ragusa R, Mayer-da-Silva A, Blum M, Mousavi M, Kuehni C, Mihor A, Mandalà M, Trama A

Corrigendum to "Incidence and prognosis of cutaneous melanoma in European adolescents and young adults (AYAs): EUROCARE-6 retrospective cohort results" [Eur J Cancer 213 (2024):115079].

EUROPEAN JOURNAL OF CANCER, 2025, 218, 115295-115295 dx.doi.org/10.1016/j.ejca.2025.115295
Masvidal Hernandez M, Cros Costa S, Salvador Coloma C, Quilez Cutillas A, Barretina-Ginesta MP, Cotes Sanchís A

First-line PARP inhibitor maintenance treatment in ovarian carcinoma for older adult women: a review of the current literature.

CLINICAL & TRANSLATIONAL ONCOLOGY, 2025, 27, 417-424 dx.doi.org/10.1007/s12094-024-03609-y
Sabaté-Ortega, J, Teixidor-Vilà, E, Sais, E, Hernandez-Martínez, A, Montañés-Ferrer, C, Coma, N, Polonio-Alcalá, E, Pineda, V, Bosch-Barrera, J

Cardiovascular toxicity induced by immunotherapy in non-small cell lung cancer: a systematic review and meta-analysis of observational studies

Frontiers in oncology, 2025, 15 dx.doi.org/10.3389/fonc.2025.1528950
Competitive projects
Precision Oncology in Girona

Estudio descriptivo y efecto del ritmo circadiano en el tratamiento con quimio-inmunoterapia neoadyuvante del cáncer del pulmón de célula no pequeña en estadios precoces. Un estudio multicéntrico con resultados de Real World Data (RWD)

Codi oficial: 2024_GECP_CMF Start date:01/12/2024 Data fi: 30/11/2026 Investigador/a principal: CLAUDIA MONTAÑES FERRER Organisme finançador: GRUPO ESPAÑOL DE CANCER DE PULMON
Precision Oncology in Girona

Y-RNAs AS NON-INVASIVE BIOMARKERS FOR EARLY CANCER DETECTION

Codi oficial: IDEAS246813BRUN Start date:01/12/2024 Data fi: 30/11/2026 Investigador/a principal: JOAN BRUNET VIDAL Organisme finançador: ASSOCIACIÓ ESPANYOLA CONTRA EL CÀNCER
Precision Oncology in Girona

CarboSign7 for cancer diagnosis: Biosampling optimization and validation for gastric and lung cancer

Codi oficial: CI23-20369 Start date:30/10/2023 Data fi: 30/10/2025 Investigador/a principal: ADELAIDA GARCIA VELASCO Organisme finançador: FUNDACIÓN BANCARIA LA CAIXA
Precision Oncology in Girona

Avaluació del grau de resposta patològica tumoral al tractament amb inhibidors de l’angiogènesi i del factor de creixement epidèrmic, en combinació a quimioteràpia, de les metàstasi hepàtiques de càncer colorectal ressecades

Codi oficial: VEGF/EGFR Start date:11/06/2022 Data fi: 31/12/2025 Investigador/a principal: XAVIER HERNÁNDEZ YAGÜE Organisme finançador: FUNDACIÓ ACADÈMIA CIÈNCIES MÈDIQUES
Precision Oncology in Girona

CANCER PREVENTION VS CANCER TREATMENT: THE RARE TUMOUR RISK SYNDROMES BATTLE

Codi oficial: 101095483 Start date:01/01/2023 Data fi: 31/12/2025 Investigador/a principal: JOAN BRUNET VIDAL Organisme finançador: EUROPEAN COMISSION
Precision Oncology in Girona

Premio mejor póster SEOM2024 con el título “Efecto del ritmo circadiano inmunológico en el tratamiento del cáncer de pulmón de célula no pequeña localmente avanzado tratado con inmunoterapia de consolidación”.

Codi oficial: Premio mejor póster SEOM2024 Start date:01/01/2025 Data fi: 31/12/2025 Investigador/a principal: ELISABET BUJONS BUSCARONS, ESTER OLIVA POCH Organisme finançador: SOCIEDAD ESPAÑOLA DE ONCOLOGÍA MÉDICA (SEOM)
Precision Oncology in Girona

Evaluación de un nuevo biomarcador pan-cáncer para mejorar la predicción de respuesta a inmunoterapia.

Codi oficial: biomarcador pan-cáncer Start date:19/10/2020 Data fi: 01/12/2025 Investigador/a principal: JOAN BRUNET VIDAL Organisme finançador: SOCIEDAD ESPAÑOLA DE ONCOLOGÍA MÉDICA (SEOM)
Precision Oncology in Girona

A therapeutic strategy to co-target brain metastasis-initiating and hyperlipidemia-driving mechanisms in lorlatinib-treated NSCLC

Codi oficial: Pfizer 2019 Joaquim Bosch Start date:05/07/2019 Data fi: 31/12/2025 Investigador/a principal: JOAQUIM BOSCH BARRERA, JAVIER ABEL MENÉNDEZ MENÉNDEZ Organisme finançador: PFIZER, S.L.U.
Precision Oncology in Girona

TALENT GIRONÍ 2024- (execució nov24- jul25)

Codi oficial: TALENT GIRONÍ 2024 Start date:01/11/2024 Data fi: 31/07/2025 Investigador/a principal: ROSER FORT CULILLAS, CARLOS MOLINER ABÓS, HELENA PLA JUHER
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