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The Digestive Diseases and Microbiota group is interested in understanding the role of these microorganisms (bacteria among others) living in the intestine and how alterations to their proportions affect human health and disease. We are a multidisciplinary team with basic basic and clinic researchers. To respond to our research topics we are conducting clinical studies in humans and independent culture techniques focused on DNA sequencing using PCR techniques, and specifically, the 16S rRNA gene of microorganisms present in tissue samples, saliva and / or faeces from patients with different pathologies. These tools allow us to address a whole series of biological issues from a descriptive and functional perspective with the background of exploring the role of intestinal microbiota as an activating agent and as a diagnostic and prognostic tool in the field of different diseases: Crohn's disease and ulcerative colitis, colon cancer, irritable bowel syndrome, celiac disease, chronic pancreatitis, fatty liver, rheumatoid arthritis, colon, and pancreas cancer.

Main lines of research

Our main line of research is the study of microbiota in digestive diseases (inflammatory intestinal disease, colorectal cancer, chronic pancreatitis, pancreatic cancer, hepatic steatosis, hepatocarcinoma, etc.), with the intention of finding microbiological markers that can be used as prognosis, diagnosis and monitoring tools and support for these digestive pathologies.

Strategic objectives

Our group will focus its efforts around three very clear goals:

  1. Dysbiosis indicators

Work on a broad-ranging study in the correlation of indices developed during the previous period (MC and CRC) with clinical determinants of intestinal diseases for risk determination, pre-diagnosis screening and intestinal disease monitoring.

These tools for monitoring the state of the intestinal microbiota will allow delve deeper into the concept of mucous healing,  a condition that involves the reversion of a dysbiosis situation to basal or normal conditions.

  1. AIEC

Identify genetic elements involved in the pathotype "Adherent-invasive Escherichia coli' and molecular tool design for its detection in patients with Crohn's disease

  1. Hepatopancreatic line

Explore the establishment of a new line in the hepatopancreatic field dedicated to exploring the possible microbiological markers in faeces from patients with chronic pancreatitis that progress to pancreatic cancer and patients with hepatic steatosis who develop hepatocarcinoma. In fact this year (2015), Dr. Silvia Virolés has begun her thesis focusing on the study of the microbiota during the different phases of hepatic steatosis until the onset of hepatocarcinoma, with the aim of finding a microbiological marker linked to the prognosis for this disease.

Publications

Garre-Olmo J, Turró-Garriga O, Martí-Lluch R, Zacarías-Pons L, Alves-Cabratosa L, Serrano-Sarbosa D, Vilalta-Franch J, Ramos R, Girona Healthy Region Study Group

Changes in lifestyle resulting from confinement due to COVID-19 and depressive symptomatology: A cross-sectional a population-based study.

COMPREHENSIVE PSYCHIATRY, 2021, 104, 152214-152214 dx.doi.org/10.1016/j.comppsych.2020.152214
0

Epigenetic footprint enables molecular risk stratification of hepatoblastoma with clinical implications.

JOURNAL OF HEPATOLOGY, 2020, 73, 328-341 dx.doi.org/10.1016/j.jhep.2020.03.025

Alsius M, Ferri MJ, Buxó M, López C, Serra I, Queralt X, Acero D

Autoantibodies to cytoplasmic rods and rings in patients with hepatitis C virus infection treated with direct-acting antivirals: The role of prior treatment with interferon plus ribavirin.

GASTROENTEROLOGIA Y HEPATOLOGIA, 2019, 42, 82-89 dx.doi.org/10.1016/j.gastrohep.2018.08.005

Juanpere S, Valls L, Serra I, Osorio M, Gelabert A, Maroto A, Pedraza S

Imaging of non-neoplastic duodenal diseases. A pictorial review with emphasis on MDCT.

Insights Into Imaging, 2018, 9, 121-135 dx.doi.org/10.1007/s13244-018-0593-6

Acero Fernández D, Ferri Iglesias MJ, Buxó Pujolràs M, López Nuñez C, Serra Matamala I, Queralt Molés X, Aldeguer Manté X

Changes in the epidemiology and distribution of the hepatitis C virus genotypes in North-Eastern Spain over the last 35 years.

GASTROENTEROLOGIA Y HEPATOLOGIA, 2018, 41, 2-11 dx.doi.org/10.1016/j.gastrohep.2017.09.004

Codina J, Gelabert A, Casellas M, Preciado Borreguero D, Huertas C, Falgueras L, Pedraza S

Percutaneous Plastic Stent Insertion for Treatment of Disconnected Pancreatic Duct.

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 2017, 28, 1203-1205 dx.doi.org/10.1016/j.jvir.2017.04.010

Busquets D, Mas-de-Xaxars T, López-Siles M, Martínez-Medina M, Bahí A, Sàbat M, Louvriex R, Miquel-Cusachs JO, Garcia-Gil JL, Aldeguer X

Anti-tumour Necrosis Factor Treatment with Adalimumab Induces Changes in the Microbiota of Crohn's Disease.

JOURNAL OF CROHNS & COLITIS, 2015, 9, 899-906 dx.doi.org/10.1093/ecco-jcc/jjv119

Oliveras B, Albert M, López C, Fort E, Peries L, Gutiérrez L, Busquets D, Uchima H, Aldeguer X, Piñol V

A case report of gastrointestinal histoplasmosis in a patient treated with infliximab.

Clinical Journal of Gastroenterology dx.doi.org/10.1007/s12328-020-01298-y
Competitive projects
Codi oficial: La Marató 201912-31 Start date:30/09/2020 Data fi: 30/09/2023 Investigador/a principal: XAVIER ALDEGUER MANTE Organisme finançador: FUNDACIO LA MARATO TV3 Ajuda: 199,812.50 €
Transfer
Patents

López Siles Mireia, García Gil Librado Jesús, Aldeguer Manté Xavier, Martínez Medina Margarita
METHOD FOR THE QUANTIFICATION OF FAECALIBACTERIUM PRAUSNITZII PHYLOGROUP I AND/OR PHYLOGROUP II MEMBERS AND THE USE THEREOF AS BIOMARKERS
Número de publicació: WO2017025617
Data de publicació: 2017-02-16

Serra Pagès Mariona, García-Gil Jesús, Mas De Xaxars Teresa, Aldeguer Xavier
METHOD FOR DIAGNOSING COLORECTAL CANCER FROM A HUMAN FECES SAMPLE BY QUANTITIVE PCR, PRIMERS AND KIT
Número de publicació: WO2015132273
Data de publicació: 2015-09-11

 

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