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The Digestive Diseases and Microbiota group is interested in understanding the role of these microorganisms (bacteria among others) living in the intestine and how alterations to their proportions affect human health and disease. We are a multidisciplinary team with basic basic and clinic researchers. To respond to our research topics we are conducting clinical studies in humans and independent culture techniques focused on DNA sequencing using PCR techniques, and specifically, the 16S rRNA gene of microorganisms present in tissue samples, saliva and / or faeces from patients with different pathologies. These tools allow us to address a whole series of biological issues from a descriptive and functional perspective with the background of exploring the role of intestinal microbiota as an activating agent and as a diagnostic and prognostic tool in the field of different diseases: Crohn's disease and ulcerative colitis, colon cancer, irritable bowel syndrome, celiac disease, chronic pancreatitis, fatty liver, rheumatoid arthritis, colon, and pancreas cancer.

Main lines of research

Our main line of research is the study of microbiota in digestive diseases (inflammatory intestinal disease, colorectal cancer, chronic pancreatitis, pancreatic cancer, hepatic steatosis, hepatocarcinoma, etc.), with the intention of finding microbiological markers that can be used as prognosis, diagnosis and monitoring tools and support for these digestive pathologies.

Strategic objectives

Our group will focus its efforts around three very clear goals:

  1. Dysbiosis indicators

Work on a broad-ranging study in the correlation of indices developed during the previous period (MC and CRC) with clinical determinants of intestinal diseases for risk determination, pre-diagnosis screening and intestinal disease monitoring.

These tools for monitoring the state of the intestinal microbiota will allow delve deeper into the concept of mucous healing,  a condition that involves the reversion of a dysbiosis situation to basal or normal conditions.

  1. AIEC

Identify genetic elements involved in the pathotype "Adherent-invasive Escherichia coli' and molecular tool design for its detection in patients with Crohn's disease

  1. Hepatopancreatic line

Explore the establishment of a new line in the hepatopancreatic field dedicated to exploring the possible microbiological markers in faeces from patients with chronic pancreatitis that progress to pancreatic cancer and patients with hepatic steatosis who develop hepatocarcinoma. In fact this year (2015), Dr. Silvia Virolés has begun her thesis focusing on the study of the microbiota during the different phases of hepatic steatosis until the onset of hepatocarcinoma, with the aim of finding a microbiological marker linked to the prognosis for this disease.

Publications
Thomas CE, Lin Y, Kim M, Kawaguchi ES, Qu C, Um CY, Lynch BM, Van Guelpen B, Tsilidis K, Carreras-Torres R, van Duijnhoven FJ, Sakoda LC, Campbell PT, Tian Y, Chang-Claude J, Bézieau S, Budiarto A, Palmer JR, Newcomb PA, Casey G, Le Marchand L, Giannakis M, Li CI, Gsur A, Newton C, Obón-Santacana M, Moreno V, Vodicka P, Brenner H, Hoffmeister M, Pellatt AJ, Schoen RE, Dimou N, Murphy N, Gunter MJ, Castellví-Bel S, Figueiredo JC, Chan AT, Song M, Li L, Bishop DT, Gruber SB, Baurley JW, Bien SA, Conti DV, Huyghe JR, Kundaje A, Su YR, Wang J, Keku TO, Woods MO, Berndt SI, Chanock SJ, Tangen CM, Wolk A, Burnett-Hartman A, Wu AH, White E, Devall MA, Díez-Obrero V, Drew DA, Giovannucci E, Hidaka A, Kim AE, Lewinger JP, Morrison J, Ose J, Papadimitriou N, Pardamean B, Peoples AR, Ruiz-Narvaez EA, Shcherbina A, Stern MC, Chen X, Thomas DC, Platz EA, Gauderman WJ, Peters U, Hsu L

Characterization of additive gene-environment interactions for colorectal cancer risk.

Epidemiology, 2025, 36, 126-138 dx.doi.org/10.1097/EDE.0000000000001795
Mesonero F, Zabana Y, Fernández-Clotet A, Solá A, Caballol B, Leo-Carnerero E, García MJ, Bertoletti F, Bastida G, Suris G, Casis B, Ferreiro-Iglesias R, Calafat M, Jiménez I, Miranda-Bautista J, Lamuela LJ, Fajardo I, Torrealba L, Nájera R, Sáiz-Chumillas RM, González-Partida I, Vicuña M, García-Morales N, Gutiérrez A, López-García A, Benítez JM, Rubín de Célix C, Tejido C, Brunet E, Hernandez-Camba A, Suárez C, Rodríguez-Lago I, Piqueras M, Castaño A, Ramos L, Sobrino A, Rodríguez-Grau MC, Elosua A, Montoro M, Baltar R, Huguet JM, Hermida B, Caballero-Mateos A, Sánchez-Guillén L, Bouhmidi A, Pajares R, Baston-Rey I, López-Sanromán A, Albillos A, Barreiro-de Acosta M

Types, behaviour and therapeutic requirements of inflammatory pouch disorders: Results from the RESERVO study of GETECCU.

DIGESTIVE AND LIVER DISEASE, 2025, 57, 566-573 dx.doi.org/10.1016/j.dld.2024.09.023
Peruchet-Noray L, Dimou N, Cordova R, Fontvieille E, Jansana A, Gan Q, Breeur M, Baurecht H, Bohmann P, Konzok J, Stein MJ, Dahm CC, Zilhão NR, Mellemkjær L, Tjønneland A, Kaaks R, Katzke V, Inan-Eroglu E, Schulze MB, Masala G, Sieri S, Simeon V, Matullo G, Molina-Montes E, Amiano P, Chirlaque MD, Gasque A, Atkins J, Smith-Byrne K, Ferrari P, Viallon V, Agudo A, Gunter MJ, Bonet C, Freisling H, Carreras-Torres R

Nature or nurture: genetic and environmental predictors of adiposity gain in adults.

EBioMedicine, 2025, 111, 105510-105510 dx.doi.org/10.1016/j.ebiom.2024.105510
Lluansí A, Llirós M, Carreras-Torres R, Bahí A, Capdevila M, Feliu A, Vilà-Quintana L, Elias-Masiques N, Cueva E, Peries L, Torrealba L, Miquel-Cusachs JO, Sàbat M, Busquets D, López C, Delgado-Aros S, Garcia-Gil LJ, Elias I, Aldeguer X

Impact of bread diet on intestinal dysbiosis and irritable bowel syndrome symptoms in quiescent ulcerative colitis: A pilot study

Plos One, 2024, 19 dx.doi.org/10.1371/journal.pone.0297836
Velamazán R, López-Guillén P, Martínez-Domínguez SJ, Abad Baroja D, Oyón D, Arnau A, Ruiz-Belmonte LM, Tejedor-Tejada J, Zapater R, Martín-Vicente N, Fernández-Esparcia PJ, Julián Gomara AB, Sastre Lozano V, Manzanares García JJ, Chivato Martín-Falquina I, Andrés Pascual L, Torres Monclus N, Zaragoza Velasco N, Rojo E, Lapeña-Muñoz B, Flores V, Díaz Gómez A, Cañamares-Orbís P, Vinzo Abizanda I, Marcos Carrasco N, Pardo Grau L, García-Rayado G, Millastre Bocos J, Garcia Garcia de Paredes A, Vaamonde Lorenzo M, Izagirre Arostegi A, Lozada-Hernández EE, Velarde-Ruiz Velasco JA, de-Madaria E

Symptomatic gallstone disease: Recurrence patterns and risk factors for relapse after first admission, the RELAPSTONE study

UNITED EUROPEAN GASTROENTEROLOGY JOURNAL, 2024, 12, 286-298 dx.doi.org/10.1002/ueg2.12544
Barreira-Díaz A, Riveiro-Barciela M, Fernández-Bonilla EM, Bernal V, Castiella A, Casado-Martín M, Delgado C, Londoño MC, Díaz-González Á, Pérez-Medrano I, Conthe A, Sala M, Mateos B, Gómez-Camarero J, Antón-Conejero D, Pozo-Calzada CD, Cuenca F, Villena AV, Salcedo M

Outcomes and factors associated with relapse of vaccine-induced liver injury after SARS CoV-2 immunization: A nationwide study

ANNALS OF HEPATOLOGY, 2024, 29, 101489-101489 dx.doi.org/10.1016/j.aohep.2024.101489
Salazar J, Garcia-Planella E, Fernández-Clotet A, Esteve M, Gisbert JP, Busquets D, Lucendo A, Márquez L, Guardiola J, Martín-Arranz MD, Iglesias E, Monfort D, Villoria A, Cañete F, Bell O, Ricart E, Zabana Y, Chaparro M, Domènech E, Gordillo J

Genetic biomarkers of methotrexate response and safety in Crohn's disease: Data from the Spanish ENEIDA registry

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2024, 90, 1301-1311 dx.doi.org/10.1111/bcp.16017
Mesonero F, Zabana Y, Fernández-Clotet A, Leo-Carnerero E, Caballol B, Núñez-Ortiz A, García MJ, Bertoletti F, Mínguez A, Suris G, Casis B, Ferreiro-Iglesias R, Calafat M, Jiménez I, Miranda-Bautista J, Lamuela LJ, Fajardo I, Torrealba L, Nájera R, Sáiz-Chumillas RM, González I, Vicuña M, García-Morales N, Gutiérrez A, López-García A, Benítez JM, Rubín de Célix C, Tejido C, Brunet E, Hernández-Camba A, Suárez C, Rodríguez-Lago I, Piqueras M, Castaño A, Ramos L, Sobrino A, Rodríguez-Grau MC, Elosua A, Montoro M, Baltar R, Huguet JM, Hermida B, Caballero-Mateos A, Sánchez-Guillén L, Bouhmidi A, Pajares R, Baston-Rey I, López-Sanromán A, Albillos A, Barreiro-de Acosta M

Effectiveness and safety of azathioprine for inflammatory pouch disorders: results from the RESERVO study of GETECCU

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY, 2024, 17 dx.doi.org/10.1177/17562848241234476
Medina-Prado L, Sala-Miquel N, Aicart-Ramos M, López-Cardona J, Ponce-Romero M, Ortíz O, Pellisé M, Aguilera L, Díez-Redondo P, Núñez-Rodríguez H, Seoane A, Domper-Arnal MJ, Borao-Laguna C, González-Bernardo Ó, Suárez A, Muñoz-Tornero M, Bustamante-Balén M, Soutullo-Castiñeiras C, Balleste-Peris B, Esteban P, Jiménez-Gómez M, Albert M, Lucas J, Valdivieso-Cortázar E, López-Serrano A, Solano M, Tejedor-Tejada J, Trelles M, Zapater P, Jover R

Effect of the SARS-CoV-2 pandemic on colorectal cancer diagnosis and prognosis

CANCER MEDICINE, 2024, 13 dx.doi.org/10.1002/cam4.6923
Pla H, Felip E, Obadia V, Pernas S, Viñas G, Margelí M, Fort-Culillas R, Del Barco S, Sabaté N, Fort E, Lezcano C, Cirauqui B, Quiroga V, Stradella A, Gil Gil M, Esteve A, Recalde S

Elderly patients with hormone receptor-positive HER2-negative metastatic breast cancer treated with CDK4/6 inhibitors in a multicentre cohort

CLINICAL & TRANSLATIONAL ONCOLOGY, 2024, 26, 1748-1758 dx.doi.org/10.1007/s12094-024-03399-3
Competitive projects
Codi oficial: 2021 SGR 01366 Start date:01/01/2022 Data fi: 30/06/2025 Investigador/a principal: ROBERT CARRERAS TORRES Organisme finançador: AGÈNCIA DE GESTIÓ UNIVERSITARIS I RECERCA
Codi oficial: CP21/00058 Start date:01/01/2022 Data fi: 31/12/2026 Investigador/a principal: ROBERT CARRERAS TORRES Organisme finançador: INSTITUTO DE SALUD CARLOS III
Transfer
Patents

López Siles Mireia, García Gil Librado Jesús, Aldeguer Manté Xavier, Martínez Medina Margarita
METHOD FOR THE QUANTIFICATION OF FAECALIBACTERIUM PRAUSNITZII PHYLOGROUP I AND/OR PHYLOGROUP II MEMBERS AND THE USE THEREOF AS BIOMARKERS
Número de publicació: WO2017025617
Data de publicació: 2017-02-16

Serra Pagès Mariona, García-Gil Jesús, Mas De Xaxars Teresa, Aldeguer Xavier
METHOD FOR DIAGNOSING COLORECTAL CANCER FROM A HUMAN FECES SAMPLE BY QUANTITIVE PCR, PRIMERS AND KIT
Número de publicació: WO2015132273
Data de publicació: 2015-09-11

 

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