hrs4r
 I want to donate

The Digestive Diseases and Microbiota group is interested in understanding the role of these microorganisms (bacteria among others) living in the intestine and how alterations to their proportions affect human health and disease. We are a multidisciplinary team with basic basic and clinic researchers. To respond to our research topics we are conducting clinical studies in humans and independent culture techniques focused on DNA sequencing using PCR techniques, and specifically, the 16S rRNA gene of microorganisms present in tissue samples, saliva and / or faeces from patients with different pathologies. These tools allow us to address a whole series of biological issues from a descriptive and functional perspective with the background of exploring the role of intestinal microbiota as an activating agent and as a diagnostic and prognostic tool in the field of different diseases: Crohn's disease and ulcerative colitis, colon cancer, irritable bowel syndrome, celiac disease, chronic pancreatitis, fatty liver, rheumatoid arthritis, colon, and pancreas cancer.

Main lines of research

Our main line of research is the study of microbiota in digestive diseases (inflammatory intestinal disease, colorectal cancer, chronic pancreatitis, pancreatic cancer, hepatic steatosis, hepatocarcinoma, etc.), with the intention of finding microbiological markers that can be used as prognosis, diagnosis and monitoring tools and support for these digestive pathologies.

Strategic objectives

Our group will focus its efforts around three very clear goals:

  1. Dysbiosis indicators

Work on a broad-ranging study in the correlation of indices developed during the previous period (MC and CRC) with clinical determinants of intestinal diseases for risk determination, pre-diagnosis screening and intestinal disease monitoring.

These tools for monitoring the state of the intestinal microbiota will allow delve deeper into the concept of mucous healing,  a condition that involves the reversion of a dysbiosis situation to basal or normal conditions.

  1. AIEC

Identify genetic elements involved in the pathotype "Adherent-invasive Escherichia coli' and molecular tool design for its detection in patients with Crohn's disease

  1. Hepatopancreatic line

Explore the establishment of a new line in the hepatopancreatic field dedicated to exploring the possible microbiological markers in faeces from patients with chronic pancreatitis that progress to pancreatic cancer and patients with hepatic steatosis who develop hepatocarcinoma. In fact this year (2015), Dr. Silvia Virolés has begun her thesis focusing on the study of the microbiota during the different phases of hepatic steatosis until the onset of hepatocarcinoma, with the aim of finding a microbiological marker linked to the prognosis for this disease.

Publications

Sánchez A, Roos VH, Navarro M, Pineda M, Caballol B, Moreno L, Carballal S, Rodríguez-Alonso L, Ramon Y Cajal T, Llort G, Piñol V, Fernandez AL, Salces I, Picó MD, Rivas L, Bujanda L, Garzon M, Pizarro A, Martinez de Castro E, López-Arias MJ, Poves C, Garau C, Rodriguez-Alcalde D, Herraiz M, Alvarez-Urrutia C, Dacal A, Carrillo-Palau M, Cid L, Ponce M, Barreiro-Alonso E, Saperas E, Aguirre E, Romero C, Bastiaansen B, Gonzalez-Acosta M, Morales-Romero B, Ocaña T, Rivero-Sánchez L, Jung G, Bessa X, Cubiella J, Jover R, Rodríguez-Moranta F, Balmaña J, Brunet J, Castells A, Dekker E, Capella G, Serra-Burriel M, Moreira L, Pellise M, Balaguer F

Quality of Colonoscopy Is Associated With Adenoma Detection and Postcolonoscopy Colorectal Cancer Prevention in Lynch Syndrome

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2022, 20, 611 dx.doi.org/10.1016/j.cgh.2020.11.002
0

Prevalence, Abundance, and Virulence of Adherent-Invasive Escherichia coli in Ulcerative Colitis, Colorectal Cancer, and Coeliac Disease

Frontiers in Immunology, 2022, 13, 748839-748839 dx.doi.org/10.3389/fimmu.2022.748839
0

The relationship between blood pressure and risk of renal cell carcinoma

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2022, 51, 1317-1327 dx.doi.org/10.1093/ije/dyac042
0

Outcome of liver cancer patients with SARS-CoV-2 infection: An International, Multicentre, Cohort Study

LIVER INTERNATIONAL, 2022, 42, 1891-1901 dx.doi.org/10.1111/liv.15320
0

Meta-Analysis and Validation of a Colorectal Cancer Risk Prediction Model Using Deep Sequenced Fecal Metagenomes

Cancers, 2022, 14 dx.doi.org/10.3390/cancers14174214
0

Characterization of Mesothelin Glycosylation in Pancreatic Cancer: Decreased Core Fucosylated Glycoforms in Pancreatic Cancer Patients' Sera

Biomedicines, 2022, 10 dx.doi.org/10.3390/biomedicines10081942
0

Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain: Large-Scale Epidemiological Study (vol 10, 2885, 2021)

Journal of Clinical Medicine, 2022, 11 dx.doi.org/10.3390/jcm11195816
0

Eradication of neoplastic Barrett's esophagus in patients with esophageal varices with a modified endoscopic mucosal resection technique and radiofrequency ablation.

Endoscopy, 2022, 54, 261-263 dx.doi.org/10.1055/a-1516-3400
0

Endoscopic full-thickness resection in the rectum closed with PolyLoop-and-clips method using single-channel endoscope.

Endoscopy, 2022, 54, 24-25 dx.doi.org/10.1055/a-1352-2356
0

Impact of the COVID-19 pandemic on the care and outcomes of patients with NAFLD-related cirrhosis.

JHEP REPORTS, 2022, 4, 100574-100574 dx.doi.org/10.1016/j.jhepr.2022.100574
Competitive projects
Codi oficial: La Marató 201912-31 Start date:30/09/2020 Data fi: 30/09/2023 Investigador/a principal: XAVIER ALDEGUER MANTE Organisme finançador: FUNDACIO LA MARATO TV3 Ajuda: 199,812.50 €
Codi oficial: CP21/00058 Start date:01/01/2022 Data fi: 31/12/2026 Investigador/a principal: ROBERT CARRERAS TORRES Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 202,500 €
Transfer
Patents

López Siles Mireia, García Gil Librado Jesús, Aldeguer Manté Xavier, Martínez Medina Margarita
METHOD FOR THE QUANTIFICATION OF FAECALIBACTERIUM PRAUSNITZII PHYLOGROUP I AND/OR PHYLOGROUP II MEMBERS AND THE USE THEREOF AS BIOMARKERS
Número de publicació: WO2017025617
Data de publicació: 2017-02-16

Serra Pagès Mariona, García-Gil Jesús, Mas De Xaxars Teresa, Aldeguer Xavier
METHOD FOR DIAGNOSING COLORECTAL CANCER FROM A HUMAN FECES SAMPLE BY QUANTITIVE PCR, PRIMERS AND KIT
Número de publicació: WO2015132273
Data de publicació: 2015-09-11

 

Spin-offs

Job offers

Team

If you are a researcher and you are interested in collaborating with any of our research groups, please fill in this form.
I am interested in
If you are a student or you want to do an internship with any of our research groups, please fill in this form.
I am interested in

About IDIBGI!

menu