Respiratory

IDIBGI's Respiratory Research Group is composed of several researchers from the Pneumology Department. It focuses on research into bronchiectasis, diffuse interstitial diseases, COVID19, sleep disorders, lung cancer and thromboembolic pulmonary hypertension.

The research is complemented by intense clinical activity, which has led the group to be invited to conferences in international congresses, to carrying out draft reviews and to publishing in high impact journals, as well as to being experts in the field of respiratory diseases, both nationally and internationally.

Main lines of research

Bronchiectasis: Etiology, diagnosis, and treatment
Sleep disorders: Diagnosis in primary medicine and vascular repercussions of the disease
Pulmonary hypertension
Early diagnosis of lung cancer
Occupational respiratory pathologies
Diffuse interstitial lung disease

Strategic objectives

Bronchiectasis: research into different aetiologies, including cystic fibrosis, bronchial infection and treatment.
Obstructive Sleep Apnoea Syndrome (OSAS): early diagnosis, diagnosis in the primary care setting, vascular complications; endothelial and metabolic dysfunction and identification of plasma and cellular biomarkers.
Diffuse interstitial and occupational diseases: silicosis in marble workers; asbestos-associated pathology.
Chronic Thromboembolic Pulmonary Hypertension (CTEPH): Research on new therapeutic targets, causes of the disease, vascular dysfunctions and in vitro 3D and in vivo models of endothelial pathology of CTEPH.
Lung Cancer: Detection of ctDNA as a diagnostic tool in lung cancer.
COVID-19: Advanced respiratory therapies in COVID-19 patients. Respiratory and vascular pulmonary sequelae in patients who have survived COVID-19.

Publications

Respiratory , Translational Research on Cardiovascular Respiratory Diseases

Poyatos P, Luque N, Sabater G, Eizaguirre S, Bonnin M, Orriols R, Tura-Ceide O

Endothelial dysfunction and cardiovascular risk in post-COVID-19 patients after 6- and 12-months SARS-CoV-2 infection.

Infection, 2024 dx.doi.org/10.1007/s15010-024-02173-5

Respiratory

Torrente-Nieto A, Rojas Calvera E, Haro-Estarriol M

Endoscopic Visualization of the Interior of a Cavitated Lung Lesion.

ARCHIVOS DE BRONCONEUMOLOGIA, 2023, 59, 50-50 dx.doi.org/10.1016/j.arbres.2022.07.015

Respiratory , Translational Research on Cardiovascular Respiratory Diseases

Orriols R, Torrente A, Campà MT, Comas-Cufí M, Tura-Ceide O, Sabater G, Vendrell M

Artificial Stone Silicosis. Progression and Laboral Impact After 3-years Follow-up.

ARCHIVOS DE BRONCONEUMOLOGIA, 2023, 59, 267-269 dx.doi.org/10.1016/j.arbres.2022.11.008

Respiratory , Translational Research on Cardiovascular Respiratory Diseases

Ayyoub S, Orriols R, Oliver E, Ceide OT

Thrombosis Models: An Overview of Common In Vivo and In Vitro Models of Thrombosis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 dx.doi.org/10.3390/ijms24032569

Respiratory , Translational Research on Cardiovascular Respiratory Diseases

Eichstaedt CA, Belge C, Chung WK, Gräf S, Grünig E, Montani D, Quarck R, Tenorio-Castano JA, Soubrier F, Trembath RC, Morrell NW

Genetic counselling and testing in pulmonary arterial hypertension: a consensus statement on behalf of the International Consortium for Genetic Studies in PAH.

EUROPEAN RESPIRATORY JOURNAL, 2023, 61 dx.doi.org/10.1183/13993003.01471-2022

Respiratory , Translational Research on Cardiovascular Respiratory Diseases

Peinado VI, Guitart M, Blanco I, Tura-Ceide O, Paul T, Barberà JA, Barreiro E

Atrophy signaling pathways in respiratory and limb muscles of guinea pigs exposed to chronic cigarette smoke: role of soluble guanylate cyclase stimulation.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2023, 324, 677-693 dx.doi.org/10.1152/ajplung.00258.2022

Respiratory , Translational Research on Cardiovascular Respiratory Diseases

Ayyoub S, Blanco I, Izquierdo-García JL, Tura-Ceide O

Editorial: Metabolic changes in vascular disorders: A path for early diagnosis and new therapeutic targets.

Frontiers In Cardiovascular Medicine, 2023, 10, 1163298-1163298 dx.doi.org/10.3389/fcvm.2023.1163298

Respiratory , Translational Research on Cardiovascular Respiratory Diseases

Poyatos P, Gratacós M, Samuel K, Orriols R, Tura-Ceide O

Oxidative Stress and Antioxidant Therapy in Pulmonary Hypertension.

Antioxidants, 2023, 12 dx.doi.org/10.3390/antiox12051006

Respiratory , Translational Research on Cardiovascular Respiratory Diseases

Blanco I, Marquina M, Tura-Ceide O, Ferrer E, Ramírez AM, Lopez-Meseguer M, Callejo M, Perez-Vizcaino F, Peinado VI, Barberà JA

Survivin inhibition with YM155 ameliorates experimental pulmonary arterial hypertension.

FRONTIERS IN PHARMACOLOGY, 2023, 14, 1145994-1145994 dx.doi.org/10.3389/fphar.2023.1145994

Respiratory

Herrero-Cortina B, Lee AL, Oliveira A, O'Neill B, Jácome C, Dal Corso S, Poncin W, Muñoz G, Inal-Ince D, Alcaraz-Serrano V, Reychler G, Bellofiore A, Tonia T, Chalmers JD, Spinou A

European Respiratory Society statement on airway clearance techniques in adults with bronchiectasis.

EUROPEAN RESPIRATORY JOURNAL, 2023, 62 dx.doi.org/10.1183/13993003.02053-2022

12 3 4 5 6 7 8

Competitive projects

Respiratory

Beneficios a largo plazo de la inhalación de una solución salina hipertónica al 7% pevio a la fisioterapia ELTGOL en bronquiectasias. Estudio randomizado y controlado.

Codi oficial: ICI23/00073 Start date:01/01/2024 Data fi: 31/12/2027 Investigador/a principal: MONTSERRAT VENDRELL RELAT Organisme finançador: INSTITUTO DE SALUD CARLOS III

Respiratory

Diagnostic and treatment of Sleep Apnea Hypopnea Syndrome in Primary Care

Codi oficial: 210450 Start date:01/01/2022 Data fi: 31/12/2024 Investigador/a principal: OLGA TURA CEIDE, ANTON OBRADOR LAGARES Organisme finançador: EUROPEAN INSTITUTE OF TECHNOLOGY

Transfer

Guies clíniques

- Martínez-García MÁ, Máiz L, Olveira C, Girón RM, de la Rosa D, Blanco M, Cantón R, Vendrell M, Polverino E, de Gracia J, Prados C. Spanish Guidelines on the Evaluation and Diagnosis of Bronchiectasis in Adults. Arch Bronconeumol. 2018 Feb;54(2):79-87. doi: 10.1016/j.arbres.2017.07.015. Epub 2017 Nov 9. English, Spanish.

- Polverino E, Goeminne PC, McDonnell MJ, Aliberti S, Marshall SE, Loebinger MR, Murris M, Cantón R, Torres A, Dimakou K, De Soyza A,, Hill AT, Haworth CS, Vendrell M, Ringshausen FC19, Subotic D20, Wilson R, Vilaró J, Stallberg B, Welte T, Rohde G, Blasi F, Elborn S, Almagro M, Timothy A, Ruddy T, Tonia T, Rigau D, Chalmers JD. European Respiratory Society guidelines for the management of adult bronchiectasis. European Respiratory Journal. 2017 Sep 9;50(3)

- Grup de Treball de l’Asma Greu de la Comissió Farmacoterapèutica de l’Institut Català de la Salut. Guia de tractament de l’asma greu amb fàrmacs biològics. Barcelona: Institut Català de la Salut; 2021.

Job offers

Endothelial dysfunction and cardiovascular risk in post-COVID-19 patients after 6- and 12-months SARS-CoV-2 infection.

Endoscopic Visualization of the Interior of a Cavitated Lung Lesion.

Artificial Stone Silicosis. Progression and Laboral Impact After 3-years Follow-up.

Thrombosis Models: An Overview of Common In Vivo and In Vitro Models of Thrombosis.

Genetic counselling and testing in pulmonary arterial hypertension: a consensus statement on behalf of the International Consortium for Genetic Studies in PAH.

Atrophy signaling pathways in respiratory and limb muscles of guinea pigs exposed to chronic cigarette smoke: role of soluble guanylate cyclase stimulation.

Editorial: Metabolic changes in vascular disorders: A path for early diagnosis and new therapeutic targets.

Oxidative Stress and Antioxidant Therapy in Pulmonary Hypertension.

Survivin inhibition with YM155 ameliorates experimental pulmonary arterial hypertension.

European Respiratory Society statement on airway clearance techniques in adults with bronchiectasis.

Guies clíniques

Team

Group leader - R4

Established researchers - R3

Postdoctorals researchers – R2

Predoctorals researchers – R1

Non-scientific research support staff

Research technicians

Nurse

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