Longitudinal analysis of the DNA methylation markers associated with childhood obesity.

Summary of the idea:

In a population-based cohort of pregnant women and their unborn children, followed from birth to 6 years of age, whole genome methylation in placenta and umbilical cord will be studied to identify DNA methylation markers associated with obesity at 6 years of age. These epigenetic markers allow the identification of children at risk of obesity in order to design personalised interventions and prevent this condition.

Objectives, impact and proposed solution:

In a population cohort of pregnant women and their unborn children, followed from birth to 6 years of age, we will study:

1. Whole genome methylation in placenta and umbilical cord to identify DNA methylation markers associated with obesity (BMI-SDS), body composition (mass fat) and adiposity (visceral fat) at 6 years of age;
2. Whether these epigenetic markers can be detected in blood samples at 6 years of age; and
3. Whether the epigenetic marks identified are modulated by different prenatal conditions.

Early identification of obesity-related epigenetic marks that persist over time may provide important information about the origin of metabolic diseases and could be used to predict and prevent childhood obesity.