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Longitudinal analysis of the DNA methylation markers associated with childhood obesity.
Summary of the idea:
In a population-based cohort of pregnant women and their unborn children, followed from birth to 6 years of age, whole genome methylation in placenta and umbilical cord will be studied to identify DNA methylation markers associated with obesity at 6 years of age. These epigenetic markers allow the identification of children at risk of obesity in order to design personalised interventions and prevent this condition.
Objectives, impact and proposed solution:
In a population cohort of pregnant women and their unborn children, followed from birth to 6 years of age, we will study:
Early identification of obesity-related epigenetic marks that persist over time may provide important information about the origin of metabolic diseases and could be used to predict and prevent childhood obesity.