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The Chromosomal Replication Group studies how cells copy their genome; a process known as chromosomal replication. All cells need to duplicate their genome before splitting, even tumour cells. For this reason, chromosomal replication has been an especially important therapeutic target to stop tumour processes.

In recent years, there have been important technical advances that are allowing us to study this cellular process at the molecular level. This new knowledge opens the doors to exploring new antitumor treatments that allow improvements in the quality of life of cancer patients.

Main lines of research
  • Development of new therapeutic targets.
  • Molecular studies of the initial and final stages of the cellular machinery responsible for copying the genome.
Strategic objectives
  • Develop new antitumor treatments, which allow for a reduction in the toxicity and side effects of current treatments.
  • Understanding, at the molecular level, the first stages of chromosomal replication.
Publications

Guerrero-Puigdevall M, Fernandez-Fuentes N, Frigola J

Stabilisation of half MCM ring by Cdt1 during DNA insertion.

NATURE COMMUNICATIONS, 2021, 12, 1746-1746 dx.doi.org/10.1038/s41467-021-21932-8
Competitive projects
Codi oficial: PID2020-120518GB-I00 Start date:01/09/2021 Data fi: 31/08/2024 Investigador/a principal: JORDI FRIGOLA MAS Organisme finançador: MINISTERIO DE ECONOMIA Y COMPETITIVIDAD MINECO / Ajuda: 181,500 €
Codi oficial: SLT017/20/000213 Start date:23/06/2021 Data fi: 31/12/2024 Investigador/a principal: JORDI FRIGOLA MAS Organisme finançador: GENERALITAT DE CATALUNYA Ajuda: 92,623.53 €
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