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The Cerebrovascular Pathology Research Group is a multidisciplinary group with a consolidated track record of more than 20 years in translational research in acute stroke. The group's different lines of research aim to identify new biomarkers and therapeutic targets for the management of cerebrovascular disease. It is a pre-consolidated research group recognised by the Generalitat de Catalunya (2107 SGR 1730) with extensive collaborations with related groups, especially the groups that integrate the ICTUS area of the Xarxa Temàtica d'Investigació Cooperativa en Salut of the Institut de Salut Carlos III.

Main lines of research
  • Study blood and radiological biomarkers that are predictive of the evolution of ischemic and haemorrhagic cerebral lesions.
  • Identification of blood biomarkers that are predictive of vulnerable atheroma plaques in patients with carotid stenosis.
  • Application and utility of advanced neuroimaging predictors in the identification of recoverable brain tissue in the ischemic penumbra and progression predictors in cerebral haemorrhage.
  • Clinical aspects in the identification of underlying etiopathogenesis in cryptogenic stroke and uncommon cause stroke.
  • Basic research on the molecular mechanisms related to cerebral ischemia and the haemorrhagic transformation of ischemic lesions into experimental models in vitro and in vivo.
Strategic objectives
  • Increasing the number of published papers with members of the group as the first/last author.
  • Consolidating the constitutive critical mass of the group in the basic research section within the same institution.
  • Increase the number of doctoral theses directed within the group.
  • Obtaining recognition as a consolidated research group by the Agència de Gestió d'Ajuts Universitaris i de Recerca de Catalunya.
Publications
Vera-Cáceres C, Nersesyan N, Obon M, Terceño M, Serena J, Álvarez-Cienfuegos J, Xuclà T, Bashir S, Silva Y

Iatrogenic Cerebral Amyloid Angiopathy: Two Case Reports to Explore Clinical Heterogeneity and Pathological Patterns.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 2025, 34, 107969-107969 dx.doi.org/10.1016/j.jstrokecerebrovasdis.2024.107969
Tomasello A, Moreu M, Terceño M, Dinia L, Barrena Caballo MR, Requena M, Jablonska M, Cendrero J, Flores A, Ortega S, Diana F, Henandez D, de Dios M, Rubiera M, Garcia-Tornel A, Rizzo F, Olivé M, Pérez-García C, Trejo Gallego C, Carmona T, Rodrigo-Gisbert M, Molina C, Ribo M

Randomized Study Comparing First-Line Dual Versus Single-Stent Retriever Technique: TWIN2WIN.

Stroke, 2025, 56, 326-334 dx.doi.org/10.1161/STROKEAHA.124.048496
Pensato U, Tanaka K, Ospel J, Aviv RI, Rodriguez D, Hill MD, Molina CA, Silva Y, Boulanger JM, Gubitz G, Bhatia R, Padma V, Roy J, Dzialowski I, Kase C, Kobayashi A, Dowlatshahi D, Demchuk AM

Validation of the Black-&-White sign to predict intracerebral hematoma expansion in the multi-center PREDICT study cohort.

INTERNATIONAL JOURNAL OF STROKE, 2025 dx.doi.org/10.1177/17474930241307466
Puig J, Werner M, Dolz G, Pascagaza A, Daunis-I-Estadella P, Comas-Cufí M, González E, Fondevila J, Vega P, Murias E, Romero V, Martínez C, Aparici-Robles F, Morales-Caba L, Remollo S, Rodríguez-Caamaño I, Pérez-García C, Rosati S, Bashir S, Vielba-Gomez I, Aixut S, Paipa AJ, Martínez-Fernández J, Aguilar Y, Fandiño E, Barbieri G, García-Villalba B, Cuba V, Castaño M, Blasco J

Distal Access Catheter Improves Balloon Guide and Stent Retriever Thrombectomy Outcomes in Nonagenarians.

JOURNAL OF NEUROIMAGING, 2025, 35 dx.doi.org/10.1111/jon.70012
Collet-Vidiella R, Camps-Renom P, Núñez-Guillén A, Quesada H, Rizzo F, Rodriguez-Villatoro N, Amaro S, Llull L, Santana D, Estrada E, Flores A, Terceño M, Bashir S, Hernández-Pérez M, Remollo S, Barrachina-Esteve O, Cánovas D, Vivas E, Rodríguez-Campello A, Mauri G, Purroy F, Ramos-Pachón A, Guasch-Jiménez M, Guisado-Alonso D, Prats-Sánchez L, Martínez-Domeño A, Lambea-Gil Á, Ezcurra-Díaz G, Branera-Pujol J, Martínez-González JP, Dinia L, Salvat-Plana M, Pérez de la Ossa N, Molina CA, Cardona P, Martí-Fàbregas J

Rescue stenting after failed mechanical thrombectomy: The RES-CAT study.

European Stroke Journal, 2025 dx.doi.org/10.1177/23969873241308680
Tomasello A, Zamarro J, Terceño M, Diaz-Perez J, Bashir S, Gramegna LL, Requena M, Diana F, Rivera E, Dios M, Hernández D, Sánchez S, Galve I, Ribo M

Clinical Results of the ANAIS Study: Mechanical Thrombectomy Using the ANA Device in Combination with a Stent Retriever in Subjects with Acute Ischemic Stroke.

AMERICAN JOURNAL OF NEURORADIOLOGY, 2025, 46, 502-509 dx.doi.org/10.3174/ajnr.A8556
Langhoff R, Vajda Z, Odrowaz-Pieniazek P, Gjoreski A, Beelen R, Deloose K, Nemes B, Ruzsa Z, Banos JL, Castro S, Faurie B, Fuß T, Piorkowski M, Király I, Vulev I, Schwindt A, Csécsei P, Tomasello Weitz A, Jonszta T, Latacz P, Galván Fernández J, Verbist J, Schröder H, Pöckler-Schöniger C, Kupcs K, Lozano Vilardell P, Rodríguez Carvajal R, Daenens K, Tenholt M, Blaško P, François O, Diaz Valiño JL, Martínez Gámez FJ, Sesselmann V, Bárzo P, Kurre W, Terceño Izaga M, Orgaz Pérez-Grueso A, Suppan K, Lacman J, Larrea Peña JA, Blasco J, Bokkers R, Cvetic V, Till V, Vallés González H, Andrassy M, van den Heuvel D, Köhler J, Müller-Hülsbeck S, Kedev S

30-Day Outcomes of Real-World Elective Carotid Stenosis Treatment Using a Dual-Layer Micromesh Stent (ROADSAVER Study).

CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, 2025, 48, 427-437 dx.doi.org/10.1007/s00270-025-04003-z
Veltkamp, R, Korompoki, E, Harvey, KH, Harvey, ER, Fiessler, C, Malzahn, U, Montaner, J, Caso, V, Sibon, I, Ringleb, P, Halse, O, Ullmann, S, Schuhmann, C, Todd, GP, Haas, K, Lachaize, M, D'Aoust, T, Enzinger, C, Ropele, S, Fandler-Hoefler, S, Haidegger, M, Wang, YZ, Wafa, HA, Cancelloni, V, Mosconi, MG, Lip, GYH, Lane, DA, Haefeli, WE, Foerster,, Wurmbach, VS, Nielsen, PB, Hajjar, K, Mueller, P, Poli, S, Purrucker, J, Laible, M, D'Anna, L, Silva, Y, Chacon, RD, Martínez-Sánchez, P, Boulanger, M, Norrving, B, Paré, G, Wachter, R, Ntaios, G, Wolfe, CDA, Heuschmann, PU

Direct oral anticoagulants versus no anticoagulation for the prevention of stroke in survivors of intracerebral haemorrhage with atrial fibrillation (PRESTIGE-AF): a multicentre, open-label, randomised, phase 3 trial

LANCET, 2025, 405, 927-936 dx.doi.org/10.1016/S0140-6736(25)00333-2
Guasch-Jiménez M, Ezcurra Díaz G, Lambea-Gil Á, Ramos-Pachón A, Martinez-Domeño A, Prats-Sanchez L, Fernández-Vidal JM, Toscano-Prat C, Marti-Fabregas J, Martínez-González JP, Fernandez-Cadenas I, Cardona P, Rodriguez-Villatoro N, Rodríguez Vázquez A, Gomis M, Xuclà-Ferrarons T, Rodriguez-Campello A, Cánovas D, Seró L, Purroy F, Salvat-Plana M, Abilleira S, Camps-Renom P

Influence of Asymptomatic Hemorrhagic Transformation After Endovascular Treatment on Stroke Outcome: A Population-Based Study.

Neurology, 2025, 104 dx.doi.org/10.1212/WNL.0000000000213509
Psychogios M, Brehm A, Ribo M, Rizzo F, Strbian D, Räty S, Arenillas JF, Martínez-Galdámez M, Hajdu SD, Michel P, Gralla J, Piechowiak EI, Kaiser DPO, Puetz V, Van den Bergh F, De Raedt S, Bellante F, Dusart A, Hellstern V, Khanafer A, Parrilla G, Morales A, Kirschke JS, Wunderlich S, Fiehler J, Thomalla G, Lemmens R, Peluso JP, Bolognese M, von Hessling A, van Es A, Kruyt ND, Coutinho JM, Castaño C, Minnerup J, van Zwam W, Dhondt E, Nolte CH, Machi P, Loehr C, Mattle HP, Buhk JH, Kaesmacher J, Dobrocky T, Papanagiotou P, Alonso A, Holtmannspoetter M, Zini A, Renieri L, Keil F, van den Wijngaard I, Kägi G, Terceño M, Wiesmann M, Amaro S, Rommers N, Balmer L, Fragata I, Katan M, Leker RR, Saver JL, Staals J, Fischer U

Endovascular Treatment for Stroke Due to Occlusion of Medium or Distal Vessels.

NEW ENGLAND JOURNAL OF MEDICINE, 2025, 392, 1374-1384 dx.doi.org/10.1056/NEJMoa2408954
Competitive projects
Cerebrovascular Pathology

Evaluación de biomarcadores predictivos de crecimiento de la hemorragia intracerebral: foco en ARNs no-codificantes y ADN libre de células.

Codi oficial: PI21/00209 Start date:01/01/2022 Data fi: 30/06/2026 Investigador/a principal: YOLANDA SILVA BLAS Organisme finançador: INSTITUTO DE SALUD CARLOS III
Cerebrovascular Pathology

Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS)- ICTUS

Codi oficial: RD21/0006/0011 - ICTUS Start date:01/01/2022 Data fi: 31/12/2025 Investigador/a principal: JOAQUIN SERENA LEAL, YOLANDA SILVA BLAS Organisme finançador: INSTITUTO DE SALUD CARLOS III
Cerebrovascular Pathology

Estudio de correlación de biomarcadores sanguíneos con la captación de la pared aneurismática en RM3T para la identificación de aneurisma cerebral inestable: estudio ANEUGIR

Codi oficial: PI22/01073 ANEUGIR Start date:01/01/2023 Data fi: 31/12/2025 Investigador/a principal: JOAQUIN SERENA LEAL, MIKEL TERCEÑO IZAGA Organisme finançador: INSTITUTO DE SALUD CARLOS III
Cerebrovascular Pathology

Impacto de la Realidad Virtual Inmersiva en la rehabilitación en la fase aguda del ictus: estudio clínico y correlación con biomarcadores sanguíneos y polimorfismos relacionados con neuroplasticidad

Codi oficial: PI24/00008 Start date:01/01/2025 Data fi: 31/12/2027 Investigador/a principal: YOLANDA SILVA BLAS Organisme finançador: INSTITUTO DE SALUD CARLOS III
Cerebrovascular Pathology

Clinical trial to evaluate the administration of ApTOLL in ambulances and the neuroprotective effect in stroke patients. RACETOLL

Codi oficial: CPP2021-008378 RACETOLL Start date:01/03/2022 Data fi: 30/09/2025 Investigador/a principal: MIKEL TERCEÑO IZAGA Organisme finançador: MINISTERIO DE ECONOMIA E INNOVACION
Cerebrovascular Pathology

RICORS-ICTUS

Codi oficial: RD24/0009/0006 Start date:01/01/2025 Data fi: 31/12/2027 Investigador/a principal: YOLANDA SILVA BLAS Organisme finançador: INSTITUTO DE SALUD CARLOS III
Cerebrovascular Pathology

Ajuts per donar suport a les activitats dels grups de recerca de Catalunya (SGR-Ca 2021) - Patologia Cerebrovascular

Codi oficial: 2021 SGR 01608 Start date:01/01/2022 Data fi: 30/06/2025 Investigador/a principal: YOLANDA SILVA BLAS Organisme finançador: AGÈNCIA DE GESTIÓ UNIVERSITARIS I RECERCA
Transfer
Patents

Joaquín Serena, Carme Gubern, Yolanda Silva, Mikel Terceño, Saima Bashir, José Castillo, Tomás Sobrino.
METHOD FOR THE DIFFERENTIAL DIAGNOSIS OF SYMPTOMATIC VERSUS ASYMPTOMATIC CAROTID STENOSIS
Número de publicació: WO2020234269
Data de publicació: 2020-11-26

Guies clíniques

- Guies mèdiques oficials de diagnòstic i tractament de la Societat Catalana de Neurologia (SCN) (3ª edició - 2019). Protocol de tractament. Diagnòstic i tractament de les malalties vasculars cerebrals. 2019.

- Guies Societat Catalana de Neurologia 2018:Diagnòstic i Tractament de les malalties cerebrovasculars. Capítol: Hemorràgia intracerebral.

- Alonso de Leciñana M, Egido JA, Casado I, Ribó M, Dávalos A, Masjuan J, Caniego JL, Martínez Vila E, Díez Tejedor E; ad hoc committee of the SEN Study Group for Cerebrovascular Diseases, Fuentes B, Álvarez-Sabin J, Arenillas J, Calleja S, Castellanos M, Castillo J, Díaz-Otero F, López-Fernández JC, Freijo M, Gállego J, García-Pastor A, Gil-Núñez A, Gilo F, Irimia P, Lago A, Maestre J, Martí-Fábregas J, Martínez-Sánchez P, Molina C, Morales A, Nombela F, Purroy F, Rodríguez-Yañez M, Roquer J, Rubio F, Segura T, Serena J, Simal P, Tejada J, Vivancos J. “Guidelines for the treatment of acute ischaemic stroke”. Neurologia. 2014; 29:102-22. PMID: 22152803. I.F.: 1.35.

- Vivancos J, Gilo F, Frutos R, Maestre J, García-Pastor A, Quintana F, Roda JM, Ximénez-Carrillo A; por el Comité ad hoc del Grupo de Estudio de Enfermedades Cerebrovasculares de la SEN:, Díez Tejedor E, Fuentes B, Alonso de Leciñana M, Alvarez-Sabin J, Arenillas J, Calleja S, Casado I, Castellanos M, Castillo J, Dávalos A, Díaz-Otero F, Egido JA, Fernández JC, Freijo M, Gállego J, Gil-Núñez A, Irimia P, Lago A, Masjuan J, Martí-Fábregas J, Martínez-Sánchez P, Martínez-Vila E, Molina C, Morales A, Nombela F, Purroy F, Ribó M, Rodríguez-Yañez M, Roquer J, Rubio F, Segura T, Serena J, Simal P, Tejada J. “Guía de actuación clínica en la hemorragia subaracnoidea. Sistemática diagnóstica y tratamiento”. Neurologia. 2014;29:353-70. PMID: 23044408. I.F.: 1.35.

- Fuentes B, Gállego J, Gil-Nuñez A, Morales A, Purroy F, Roquer J, Segura T, Tejada J, Lago A, Díez-Tejedor E; por el Comitéad hoc del Grupo de Estudio de Enfermedades Cerebrovasculares de la SEN:, Alonso de Leciñana M, Alvarez-Sabin J, Arenillas J, Calleja S, Casado I, Castellanos M, Castillo J, Dávalos A, Díaz-Otero F, Egido JA, López-Fernández JC, Freijo M, García Pastor A, Gilo F, Irimia P, Maestre J, Masjuan J, Martí-Fábregas J, Martínez-Sánchez P, Martínez-Vila E, Molina C, Nombela F, Ribó M, Rodríguez-Yañez M, Rubio F, Serena J, Simal P, Vivancos J; Comité ad hoc del Grupo de Estudio de Enfermedades Cerebrovasculares de la SEN. “Guidelines for the preventive treatment of ischaemic stroke and TIA (II). Recommendations according to aetiological sub-type”. Neurologia. 2014;29:168-83. PMID: 21937151. I.F.: 1.35

- Fuentes B,Amaro S,Alonso de Leciñana M,Arenillas JF,Ayo Martín O,Castellanos M,Freijo M,García Pastor A,Gomis M,Gómez Choco M,López Cancio E,Martínez Sánchez P,Morales A,Palacio Portilla EJ,Rodríguez Yáñez M,Roquer J,Segura T,Serena J,Vivancos Mora J,Comité ad hoc del Grupo de Estudio de Enfermedades Cerebrovasculares de la S. Stroke prevention in patients with type 2 diabetes or prediabetes. Recommendations  from the Cerebrovascular Diseases Study Group, Spanish Society of Neurology.Neurologia. 2021. 36. (4):p. 305-323. IF:3,109. (Q3).

- García Pastor A,López Cancio Martínez E,Rodríguez Yáñez M,Alonso de Leciñana M,Amaro S,Arenillas JF,Ayo Martín O,Castellanos M,Fuentes B,Freijo MM,Gomis M,Gómez Choco M,Martínez Sánchez P,Morales A,Palacio Portilla EJ,Segura T,Serena J,Vivancos Mora J,Roquer J,Ad hoc committee of the Spanish Society of Neurology's Cerebrovascular Disease S. Recommendations of the Spanish Society of Neurology for the prevention of stroke. Interventions on lifestyle and air pollution.Neurologia (Engl Ed). 2021. 36. (5):p. 377-387.

- Rodríguez Yañez M,Gómez Choco M,López Cancio E,Amaro S,Alonso de Leciñana M,Arenillas JF,Ayo Martín O,Castellanos M,Freijo MM,García Pastor A,Gomis M,Martínez Sánchez P,Morales A,Palacio Portilla EJ,Roquer J,Segura T,Serena J,Vivancos Mora J,Fuentes B,ad hoc committee of the Spanish Society of Neurology's Study Group for C. Stroke prevention in patients with arterial hypertension: Recommendations of the Spanish Society of Neurology's Stroke Study Group. Neurologia (Engl Ed). 2021. 36. (6):p. 462-471.

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