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The Cerebrovascular Pathology Research Group is a multidisciplinary group with a consolidated track record of more than 20 years in translational research in acute stroke. The group's different lines of research aim to identify new biomarkers and therapeutic targets for the management of cerebrovascular disease. It is a pre-consolidated research group recognised by the Generalitat de Catalunya (2107 SGR 1730) with extensive collaborations with related groups, especially the groups that integrate the ICTUS area of the Xarxa Temàtica d'Investigació Cooperativa en Salut of the Institut de Salut Carlos III.

Main lines of research
  • Study blood and radiological biomarkers that are predictive of the evolution of ischemic and haemorrhagic cerebral lesions.
  • Identification of blood biomarkers that are predictive of vulnerable atheroma plaques in patients with carotid stenosis.
  • Application and utility of advanced neuroimaging predictors in the identification of recoverable brain tissue in the ischemic penumbra and progression predictors in cerebral haemorrhage.
  • Clinical aspects in the identification of underlying etiopathogenesis in cryptogenic stroke and uncommon cause stroke.
  • Basic research on the molecular mechanisms related to cerebral ischemia and the haemorrhagic transformation of ischemic lesions into experimental models in vitro and in vivo.
Strategic objectives
  • Increasing the number of published papers with members of the group as the first/last author.
  • Consolidating the constitutive critical mass of the group in the basic research section within the same institution.
  • Increase the number of doctoral theses directed within the group.
  • Obtaining recognition as a consolidated research group by the Agència de Gestió d'Ajuts Universitaris i de Recerca de Catalunya.
Publications

Escrichs A, Biarnes C, Garre-Olmo J, Fernández-Real JM, Ramos R, Pamplona R, Brugada R, Serena J, Ramió-Torrentà L, Coll-De-Tuero G, Gallart L, Barretina J, Vilanova JC, Mayneris-Perxachs J, Essig M, Figley CR, Pedraza S, Puig J, Deco G

Whole-Brain Dynamics in Aging: Disruptions in Functional Connectivity and the Role of the Rich Club.

CEREBRAL CORTEX, 2021, 31, 2466-2481 dx.doi.org/10.1093/cercor/bhaa367

Rudilosso S, Laredo C, Amaro S, Renú A, Llull L, Obach V, Moreno J, Ribó M, Abilleira S, Cardona P, Martí-Fàbregas J, Pérez de la Ossa N, Ramos A, Roquer J, Serena J, Purroy F, Urra X, Chamorro Á

Clinical improvement within 24 hours from mechanical thrombectomy as a predictor of long-term functional outcome in a multicenter population-based cohort of patients with ischemic stroke.

JOURNAL OF NEUROINTERVENTIONAL SURGERY, 2021, 13, 119-123 dx.doi.org/10.1136/neurintsurg-2020-015934

Rodríguez-Yañez M, Gómez-Choco M, López-Cancio E, Amaro S, Alonso de Leciñana M, Arenillas JF, Ayo-Martín O, Castellanos M, Freijo MM, García-Pastor A, Gomis M, Martínez Sánchez P, Morales A, Palacio-Portilla EJ, Roquer J, Segura T, Serena J, Vivancos-Mora J, Fuentes B, Comité ad hoc del Grupo de Estudio de Enfermedades Cerebrovasculares de la Socie

Stroke prevention in patients with arterial hypertension: Recommendations of the Spanish Society of Neurology's Stroke Study Group.

Neurologia, 2021, 36, 462-471 dx.doi.org/10.1016/j.nrl.2020.04.031

Fuentes B, Amaro S, Alonso de Leciñana M, Arenillas JF, Ayo-Martín O, Castellanos M, Freijo M, García-Pastor A, Gomis M, Gómez Choco M, López-Cancio E, Martínez Sánchez P, Morales A, Palacio-Portilla EJ, Rodríguez-Yáñez M, Roquer J, Segura T, Serena J, Vivancos-Mora J, Comité ad hoc del Grupo de Estudio de Enfermedades Cerebrovasculares de la Socie

Stroke prevention in patients with type 2 diabetes or prediabetes. Recommendations from the Cerebrovascular Diseases Study Group, Spanish Society of Neurology.

Neurologia, 2021, 36, 305-323 dx.doi.org/10.1016/j.nrl.2020.04.030

Silva Blas Y, Diringer MN, Lo B, Masjuan J, Pérez de la Ossa N, Cardinal M, Yong F, Zhu T, Li G, Arkin S

Phase 1b Study to Evaluate Safety, Tolerability, and Maximum Tolerated Dose of PF-05230907 for Intracerebral Hemorrhage.

Stroke, 2021, 52, 294-298 dx.doi.org/10.1161/STROKEAHA.120.029789

Garre-Olmo J, Turró-Garriga O, Martí-Lluch R, Zacarías-Pons L, Alves-Cabratosa L, Serrano-Sarbosa D, Vilalta-Franch J, Ramos R, Girona Healthy Region Study Group

Changes in lifestyle resulting from confinement due to COVID-19 and depressive symptomatology: A cross-sectional a population-based study.

COMPREHENSIVE PSYCHIATRY, 2021, 104, 152214-152214 dx.doi.org/10.1016/j.comppsych.2020.152214

Terceño M, Silva Y, Bashir S, Vera-Monge VA, Cardona P, Molina C, Chamorro Á, de la Ossa NP, Hernández-Pérez M, Werner M, Camps-Renom P, Rodríguez-Campello A, Cánovas D, Purroy F, Serena J, Catalan Stroke Code and Reperfusion Consortium (Cat-SCR)

Impact of general anesthesia on posterior circulation large vessel occlusions after endovascular thrombectomy.

INTERNATIONAL JOURNAL OF STROKE, 2021, 16, 792-797 dx.doi.org/10.1177/1747493020976247

García Pastor A, López-Cancio Martínez E, Rodríguez-Yáñez M, Alonso de Leciñana M, Amaro S, Arenillas JF, Ayo-Martín O, Castellanos M, Fuentes B, Freijo MM, Gomis M, Gómez Choco M, Martínez Sánchez P, Morales A, Palacio-Portilla EJ, Segura T, Serena J, Vivancos-Mora J, Roquer J, Comité ad hoc del Grupo de Estudio de Enfermedades Cerebrovasculares de la Socie

Recommendations of the Spanish Society of Neurology for the prevention of stroke. Interventions on lifestyle and air pollution.

Neurologia, 2021, 36, 377-387 dx.doi.org/10.1016/j.nrl.2020.05.018

Arnoriaga-Rodríguez M, Mayneris-Perxachs J, Contreras-Rodríguez O, Burokas A, Ortega-Sanchez JA, Blasco G, Coll C, Biarnés C, Castells-Nobau A, Puig J, Garre-Olmo J, Ramos R, Pedraza S, Brugada R, Vilanova JC, Serena J, Barretina J, Gich J, Pérez-Brocal V, Moya A, Fernández-Real X, Ramio-Torrentà L, Pamplona R, Sol J, Jové M, Ricart W, Portero-Otin M, Maldonado R, Fernández-Real JM

Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways.

Gut, 2021, 70, 2283-2296 dx.doi.org/10.1136/gutjnl-2020-323371

Oliver L, Ramió-Pujol S, Amoedo J, Malagón M, Serrano M, Bahí A, Lluansí A, Torrealba L, Busquets D, Pardo L, Serra-Pagès M, Aldeguer X, Garcia-Gil J

A Novel Grape-Derived Prebiotic Selectively Enhances Abundance and Metabolic Activity of Butyrate-Producing Bacteria in Faecal Samples.

FRONTIERS IN MICROBIOLOGY, 2021, 12, 639948-639948 dx.doi.org/10.3389/fmicb.2021.639948
Competitive projects
Codi oficial: PI19/01776 Start date:01/01/2020 Data fi: 31/12/2022 Investigador/a principal: JOAQUIN SERENA LEAL Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 99,220 €
Codi oficial: RD16/0019/0003 Start date:01/01/2017 Data fi: 31/12/2021 Investigador/a principal: JOAQUIN SERENA LEAL Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 103,147 €
Codi oficial: FI20/00305 Start date:01/01/2021 Data fi: 31/12/2024 Investigador/a principal: JOAQUIN SERENA LEAL Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 82,400 €
Codi oficial: INT20/00056 Start date:01/01/2021 Data fi: 31/12/2022 Investigador/a principal: JOAQUIN SERENA LEAL Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 60,000 €
Codi oficial: La Marató 201734.10 Start date:01/01/2018 Data fi: 31/01/2022 Investigador/a principal: YOLANDA SILVA BLAS Organisme finançador: FUNDACIO LA MARATO TV3 Ajuda: 62,500 €
Transfer
Guies clíniques

- Guies mèdiques oficials de diagnòstic i tractament de la Societat Catalana de Neurologia (SCN) (3ª edició - 2019). Protocol de tractament. Diagnòstic i tractament de les malalties vasculars cerebrals. 2019.

- Guies Societat Catalana de Neurologia 2018:Diagnòstic i Tractament de les malalties cerebrovasculars. Capítol: Hemorràgia intracerebral.

- Alonso de Leciñana M, Egido JA, Casado I, Ribó M, Dávalos A, Masjuan J, Caniego JL, Martínez Vila E, Díez Tejedor E; ad hoc committee of the SEN Study Group for Cerebrovascular Diseases, Fuentes B, Álvarez-Sabin J, Arenillas J, Calleja S, Castellanos M, Castillo J, Díaz-Otero F, López-Fernández JC, Freijo M, Gállego J, García-Pastor A, Gil-Núñez A, Gilo F, Irimia P, Lago A, Maestre J, Martí-Fábregas J, Martínez-Sánchez P, Molina C, Morales A, Nombela F, Purroy F, Rodríguez-Yañez M, Roquer J, Rubio F, Segura T, Serena J, Simal P, Tejada J, Vivancos J. “Guidelines for the treatment of acute ischaemic stroke”. Neurologia. 2014; 29:102-22. PMID: 22152803. I.F.: 1.35.

- Vivancos J, Gilo F, Frutos R, Maestre J, García-Pastor A, Quintana F, Roda JM, Ximénez-Carrillo A; por el Comité ad hoc del Grupo de Estudio de Enfermedades Cerebrovasculares de la SEN:, Díez Tejedor E, Fuentes B, Alonso de Leciñana M, Alvarez-Sabin J, Arenillas J, Calleja S, Casado I, Castellanos M, Castillo J, Dávalos A, Díaz-Otero F, Egido JA, Fernández JC, Freijo M, Gállego J, Gil-Núñez A, Irimia P, Lago A, Masjuan J, Martí-Fábregas J, Martínez-Sánchez P, Martínez-Vila E, Molina C, Morales A, Nombela F, Purroy F, Ribó M, Rodríguez-Yañez M, Roquer J, Rubio F, Segura T, Serena J, Simal P, Tejada J. “Guía de actuación clínica en la hemorragia subaracnoidea. Sistemática diagnóstica y tratamiento”. Neurologia. 2014;29:353-70. PMID: 23044408. I.F.: 1.35.

- Fuentes B, Gállego J, Gil-Nuñez A, Morales A, Purroy F, Roquer J, Segura T, Tejada J, Lago A, Díez-Tejedor E; por el Comitéad hoc del Grupo de Estudio de Enfermedades Cerebrovasculares de la SEN:, Alonso de Leciñana M, Alvarez-Sabin J, Arenillas J, Calleja S, Casado I, Castellanos M, Castillo J, Dávalos A, Díaz-Otero F, Egido JA, López-Fernández JC, Freijo M, García Pastor A, Gilo F, Irimia P, Maestre J, Masjuan J, Martí-Fábregas J, Martínez-Sánchez P, Martínez-Vila E, Molina C, Nombela F, Ribó M, Rodríguez-Yañez M, Rubio F, Serena J, Simal P, Vivancos J; Comité ad hoc del Grupo de Estudio de Enfermedades Cerebrovasculares de la SEN. “Guidelines for the preventive treatment of ischaemic stroke and TIA (II). Recommendations according to aetiological sub-type”. Neurologia. 2014;29:168-83. PMID: 21937151. I.F.: 1.35

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