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The Cerebrovascular Pathology Research Group is a multidisciplinary group with a consolidated track record of more than 20 years in translational research in acute stroke. The group's different lines of research aim to identify new biomarkers and therapeutic targets for the management of cerebrovascular disease. It is a pre-consolidated research group recognised by the Generalitat de Catalunya (2107 SGR 1730) with extensive collaborations with related groups, especially the groups that integrate the ICTUS area of the Xarxa Temàtica d'Investigació Cooperativa en Salut of the Institut de Salut Carlos III.

Main lines of research
  • Study blood and radiological biomarkers that are predictive of the evolution of ischemic and haemorrhagic cerebral lesions.
  • Identification of blood biomarkers that are predictive of vulnerable atheroma plaques in patients with carotid stenosis.
  • Application and utility of advanced neuroimaging predictors in the identification of recoverable brain tissue in the ischemic penumbra and progression predictors in cerebral haemorrhage.
  • Clinical aspects in the identification of underlying etiopathogenesis in cryptogenic stroke and uncommon cause stroke.
  • Basic research on the molecular mechanisms related to cerebral ischemia and the haemorrhagic transformation of ischemic lesions into experimental models in vitro and in vivo.
Strategic objectives
  • Increasing the number of published papers with members of the group as the first/last author.
  • Consolidating the constitutive critical mass of the group in the basic research section within the same institution.
  • Increase the number of doctoral theses directed within the group.
  • Obtaining recognition as a consolidated research group by the Agència de Gestió d'Ajuts Universitaris i de Recerca de Catalunya.
Publications

Palacio-Portilla EJ, Roquer J, Amaro S, Arenillas JF, Ayo-Martín O, Castellanos M, Freijo MM, Fuentes B, García-Pastor A, Gomis M, Gómez-Choco M, López-Cancio E, Martínez-Sánchez P, Morales A, Rodríguez-Yáñez M, Segura T, Serena J, Vivancos-Mora J, de Leciñana MA

Dyslipidemias and stroke prevention: recommendations of the Study Group of Cerebrovascular Diseases of the Spanish Society of Neurology.

Neurologia, 2022, 37, 61-72 dx.doi.org/10.1016/j.nrl.2020.07.027

Suñer-Soler R, Grau-Martín A, Terceño M, Silva Y, Maldonado E, Gras ME, Font-Mayolas S, Rodrigo-Gil J, Serena J

A clinical trial comparing smoking cessation interventions at two levels of intensity in stroke patients, stratified by the presence of insular cortex lesions.

NICOTINE & TOBACCO RESEARCH, 2022, 24, 44-52 dx.doi.org/10.1093/ntr/ntab144

Gubern-Mérida C, Comajoan P, Huguet G, García-Yebenes I, Lizasoain I, Moro MA, Puig-Parnau I, Sánchez JM, Serena J, Kádár E, Castellanos M

Cav-1 Protein Levels in Serum and Infarcted Brain Correlate with Hemorrhagic Volume in a Mouse Model of Thromboembolic Stroke, Independently of rt-PA Administration.

MOLECULAR NEUROBIOLOGY, 2022, 59, 1320-1332 dx.doi.org/10.1007/s12035-021-02644-y

Remollo S, Terceño M, Werner M, Castaño C, Hernández-Pérez M, Blasco J, San Román L, Daunis-I-Estadella P, Thió-Henestrosa S, Cuba V, Gimeno A, Puig J

Combined Approach to Stroke Thrombectomy Using a Novel Short Flexible Aspiration Catheter with a Stent Retriever : Preliminary Clinical Experience.

CLINICAL NEURORADIOLOGY, 2022, 32, 393-400 dx.doi.org/10.1007/s00062-021-01065-7
0

Effect of Intra-arterial Alteplase vs Placebo Following Successful Thrombectomy on Functional Outcomes in Patients With Large Vessel Occlusion Acute Ischemic Stroke: The CHOICE Randomized Clinical Trial.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2022, 327, 826-835 dx.doi.org/10.1001/jama.2022.1645
0

Dyslipidemias and stroke prevention: Recommendations of the Study Group of Cerebrovascular Diseases of the Spanish Society of Neurology.

Neurologia (barcelona, Spain), 2022, 37, 61-72 dx.doi.org/10.1016/j.nrleng.2020.07.021
0

Predictors of Functional Outcome After Thrombectomy in Patients With Prestroke Disability in Clinical Practice.

Stroke, 2022, 29, 845-854 dx.doi.org/10.1161/STROKEAHA.121.034960
0

Effect of Direct Transportation to Thrombectomy-Capable Center vs Local Stroke Center on Neurological Outcomes in Patients With Suspected Large-Vessel Occlusion Stroke in Nonurban Areas: The RACECAT Randomized Clinical Trial.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2022, 327, 1782-1794 dx.doi.org/10.1001/jama.2022.4404
0

Progressive Lacunar Atrokes: A Predictive Score.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 2022, 31, 106510-106510 dx.doi.org/10.1016/j.jstrokecerebrovasdis.2022.106510
Competitive projects
Codi oficial: PI19/01776 Start date:01/01/2020 Data fi: 31/12/2022 Investigador/a principal: JOAQUIN SERENA LEAL Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 99,220 €
Codi oficial: FI20/00305 Start date:01/01/2021 Data fi: 31/12/2024 Investigador/a principal: JOAQUIN SERENA LEAL Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 82,400 €
Codi oficial: PI21/00209 Start date:01/01/2022 Data fi: 31/12/2024 Investigador/a principal: YOLANDA SILVA BLAS Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 135,520 €
Codi oficial: RD21/0006/0011 - ICTUS Start date:01/01/2022 Data fi: 31/12/2024 Investigador/a principal: JOAQUIN SERENA LEAL Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 199,180.30 €
Transfer
Patents

Joaquín Serena, Carme Gubern, Yolanda Silva, Mikel Terceño, Saima Bashir, José Castillo, Tomás Sobrino.
METHOD FOR THE DIFFERENTIAL DIAGNOSIS OF SYMPTOMATIC VERSUS ASYMPTOMATIC CAROTID STENOSIS
Número de publicació: WO2020234269
Data de publicació: 2020-11-26

Guies clíniques

- Guies mèdiques oficials de diagnòstic i tractament de la Societat Catalana de Neurologia (SCN) (3ª edició - 2019). Protocol de tractament. Diagnòstic i tractament de les malalties vasculars cerebrals. 2019.

- Guies Societat Catalana de Neurologia 2018:Diagnòstic i Tractament de les malalties cerebrovasculars. Capítol: Hemorràgia intracerebral.

- Alonso de Leciñana M, Egido JA, Casado I, Ribó M, Dávalos A, Masjuan J, Caniego JL, Martínez Vila E, Díez Tejedor E; ad hoc committee of the SEN Study Group for Cerebrovascular Diseases, Fuentes B, Álvarez-Sabin J, Arenillas J, Calleja S, Castellanos M, Castillo J, Díaz-Otero F, López-Fernández JC, Freijo M, Gállego J, García-Pastor A, Gil-Núñez A, Gilo F, Irimia P, Lago A, Maestre J, Martí-Fábregas J, Martínez-Sánchez P, Molina C, Morales A, Nombela F, Purroy F, Rodríguez-Yañez M, Roquer J, Rubio F, Segura T, Serena J, Simal P, Tejada J, Vivancos J. “Guidelines for the treatment of acute ischaemic stroke”. Neurologia. 2014; 29:102-22. PMID: 22152803. I.F.: 1.35.

- Vivancos J, Gilo F, Frutos R, Maestre J, García-Pastor A, Quintana F, Roda JM, Ximénez-Carrillo A; por el Comité ad hoc del Grupo de Estudio de Enfermedades Cerebrovasculares de la SEN:, Díez Tejedor E, Fuentes B, Alonso de Leciñana M, Alvarez-Sabin J, Arenillas J, Calleja S, Casado I, Castellanos M, Castillo J, Dávalos A, Díaz-Otero F, Egido JA, Fernández JC, Freijo M, Gállego J, Gil-Núñez A, Irimia P, Lago A, Masjuan J, Martí-Fábregas J, Martínez-Sánchez P, Martínez-Vila E, Molina C, Morales A, Nombela F, Purroy F, Ribó M, Rodríguez-Yañez M, Roquer J, Rubio F, Segura T, Serena J, Simal P, Tejada J. “Guía de actuación clínica en la hemorragia subaracnoidea. Sistemática diagnóstica y tratamiento”. Neurologia. 2014;29:353-70. PMID: 23044408. I.F.: 1.35.

- Fuentes B, Gállego J, Gil-Nuñez A, Morales A, Purroy F, Roquer J, Segura T, Tejada J, Lago A, Díez-Tejedor E; por el Comitéad hoc del Grupo de Estudio de Enfermedades Cerebrovasculares de la SEN:, Alonso de Leciñana M, Alvarez-Sabin J, Arenillas J, Calleja S, Casado I, Castellanos M, Castillo J, Dávalos A, Díaz-Otero F, Egido JA, López-Fernández JC, Freijo M, García Pastor A, Gilo F, Irimia P, Maestre J, Masjuan J, Martí-Fábregas J, Martínez-Sánchez P, Martínez-Vila E, Molina C, Nombela F, Ribó M, Rodríguez-Yañez M, Rubio F, Serena J, Simal P, Vivancos J; Comité ad hoc del Grupo de Estudio de Enfermedades Cerebrovasculares de la SEN. “Guidelines for the preventive treatment of ischaemic stroke and TIA (II). Recommendations according to aetiological sub-type”. Neurologia. 2014;29:168-83. PMID: 21937151. I.F.: 1.35

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