Neurodegeneration and Neuroinflammation

The Neurodegeneration and Neuroimflammation group’s mission is to work in a multidisciplinary, coordinated and translational way to increase knowledge of neurodegenerative and neuroinflammatory diseases to respond to the needs and demands of those suffering from them and their families.

Main lines of research

Clinical-care priority lines:

Study of neuropsychological alterations and cognitive rehabilitation in multiple sclerosis.
Study of the emotional impact, coping and adaptation to the diagnosis of multiple sclerosis.
Improvement of the adherence to immunomodulatory treatment in multiple sclerosis.
Use of a multi-parametric, multi-user and multi-functional database for multiple sclerosis.
Implementation of the use of electronic devices to assess disability in patients with multiple sclerosis.
Application of new cranial MR techniques as prognosis markers in multiple sclerosis.
Computer assisted systematization of lesions seen on cranial MRIs in patients with multiple sclerosis.
Application and integration of information technologies in assistance activity and research in multiple sclerosis.
Treatment of orphans in hereditary ataxia.

Priority lines in basic research:

Study of the profiles of specific miRNAs for different clinical forms and progressions of multiple sclerosis.
Study of the DNA methylation profile of patients with multiple sclerosis.
Study of the molecular mechanisms associated to neurodegeneration.
Study of the progression of cognitive function biomarkers in patients with multiple sclerosis.
Determination of biological factors (genetic and biochemical) in response to immunomodulatory treatments in multiple sclerosis.
Study of the intestinal microbes in Parkinson’s disease and other neurodegenerative diseases.
Bank of DNA, CSF, and serum samples for neuroimmunology diseases.

Strategic objectives

To be the reference group in the province of Girona in research and teaching in multiple sclerosis and other diseases
To have a national and international presence in the area of research in multiple sclerosis
To consolidate clinical research into multiple sclerosis
To consolidate basic research into multiple sclerosis
To promote and lead research into new treatments for multiple sclerosis
To begin clinical research into Parkinson’s disease and other movement disorders
To begin clinical research into Alzheimer’s and other dementias
To consolidate clinical research into hereditary ataxia
To lead research into neuropsychology of multiple sclerosis on a national level
To establishing research collaborations with other national and international groups for multiple sclerosis
To promote research into multiple sclerosis in nursing and neuropsychology
To promote training and teaching in multiple sclerosis, Parkinson’s disease, hereditary ataxia and dementias for health professionals, specialists and affected patients and relatives alike
Technological innovation in multiple sclerosis and other neurodegenerative diseases

Publications

Neurodegeneration and Neuroinflammation

Falls Predict Acute Hospitalization in Parkinson's Disease.

JOURNAL OF PARKINSONS DISEASE, 2023, 13, 105-124 dx.doi.org/10.3233/JPD-212539

Neurodegeneration and Neuroinflammation , Cardiovascular Genetics

Muñoz-San Martín M, Gómez I, Quiroga-Varela A, Gonzalez-Del Río M, Robles Cedeño R, Álvarez G, Buxó M, Miguela A, Villar LM, Castillo-Villalba J, Casanova B, Quintana E, Ramió-Torrentà L

miRNA Signature in CSF From Patients With Primary Progressive Multiple Sclerosis.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION, 2023, 10 dx.doi.org/10.1212/NXI.0000000000200069

Neurodegeneration and Neuroinflammation

Santos-García D, de Deus Fonticoba T, Cores Bartolomé C, Feal Painceiras MJ, Íñiguez-Alvarado MC, García Díaz I, Jesús S, Buongiorno MT, Planellas L, Cosgaya M, García Caldentey J, Caballol N, Legarda I, Hernández Vara J, Cabo I, López Manzanares L, González Aramburu I, Ávila Rivera MA, Gómez Mayordomo V, Nogueira V, Puente V, Dotor García-Soto J, Borrué C, Solano Vila B, Álvarez Sauco M, Vela L, Escalante S, Cubo E, Carrillo Padilla F, Martínez Castrillo JC, Sánchez Alonso P, Alonso Losada MG, López Ariztegui N, Gastón I, Kulisevsky J, Menéndez González M, Seijo M, Rúiz Martínez J, Valero C, Kurtis M, González Ardura J, Alonso Redondo R, Ordás C, López Díaz LM, McAfee D, Martinez-Martin P, Mir P, COPPADIS Study Group

Changes in Principal Caregiver Mood Affects the Mood of the Parkinson's Disease Patient: The Vicious Cycle of Illness.

JOURNAL OF PARKINSONS DISEASE, 2023, 13, 219-231 dx.doi.org/10.3233/JPD-225014

Neurodegeneration and Neuroinflammation

Monreal E, Fernández-Velasco JI, García-Sánchez MI, Sainz de la Maza S, Llufriu S, Álvarez-Lafuente R, Casanova B, Comabella M, Ramió-Torrentà L, Martínez-Rodríguez JE, Brieva L, Saiz A, Eichau S, Cabrera-Maqueda JM, Villarrubia N, Espiño M, Pérez-Miralles F, Montalbán X, Tintoré M, Quiroga-Varela A, Domínguez-Mozo MI, Rodríguez-Jorge F, Chico-García JL, Lourido D, Álvarez-Cermeño JC, Masjuan J, Costa-Frossard L, Villar LM

Association of Serum Neurofilament Light Chain Levels at Disease Onset With Disability Worsening in Patients With a First Demyelinating Multiple Sclerosis Event Not Treated With High-Efficacy Drugs.

JAMA NEUROLOGY, 2023, 80, 397-403 dx.doi.org/10.1001/jamaneurol.2023.0010

Cerebrovascular Pathology , Neurodegeneration and Neuroinflammation

García-Tornel Á, Flores A, Terceño M, Cardona P, Amaro S, Gomis M, Zaragoza J, Krupinski J, Gómez-Choco M, Mas N, Cocho D, Catena E, Purroy F, Deck M, Rubiera M, Pagola J, Rodriguez-Luna D, Juega J, Rodríguez-Villatoro N, Molina CA, Soro C, Jimenez X, Salvat-Plana M, Dávalos A, Jovin TG, Abilleira S, Pérez de la Ossa N, Ribó M

Association of Time of Day With Outcomes Among Patients Triaged for a Suspected Severe Stroke in Nonurban Catalonia.

Stroke, 2023, 54, 770-780 dx.doi.org/10.1161/STROKEAHA.122.041013

Neurodegeneration and Neuroinflammation

Santos-García D, Laguna A, Hernández-Vara J, de Deus Fonticoba T, Cores Bartolomé C, Feal Painceiras MJ, Íñiguez-Alvarado MC, García Díaz I, Jesús S, Boungiorno MT, Planellas L, Cosgaya M, García Caldentey J, Caballol N, Legarda I, Cabo I, López Manzanares L, González Aramburu I, Ávila Rivera MA, Gómez Mayordomo V, Nogueira V, Puente V, Dotor García-Soto J, Borrué C, Solano Vila B, Álvarez Sauco M, Vela L, Escalante S, Cubo E, Carrillo Padilla F, Castrillo JCM, Sánchez Alonso P, Alonso Losada MG, López Ariztegui N, Gastón I, Kulisevsky J, Menéndez González M, Seijo M, Rúiz Martínez J, Valero C, Kurtis M, Ardura JG, Alonso Redondo R, Ordás C, López Díaz LM, McAfee D, Martinez-Martin P, Mir P, On Behalf Of The Coppadis Study Group

Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson's Disease.

Journal of Clinical Medicine, 2023, 12 dx.doi.org/10.3390/jcm12041329

Neurodegeneration and Neuroinflammation

Deep Intronic FGF14 GAA Repeat Expansion in Late-Onset Cerebellar Ataxia.

NEW ENGLAND JOURNAL OF MEDICINE, 2023, 388, 128-141 dx.doi.org/10.1056/NEJMoa2207406

Neurodegeneration and Neuroinflammation

Treatment of multiple sclerosis with rituximab: A Spanish multicenter experience.

Frontiers in Neurology, 2023, 14, 1060696-1060696 dx.doi.org/10.3389/fneur.2023.1060696

Neurodegeneration and Neuroinflammation , Medical Imaging , Nutrition, Eumetabolism and Health

Contreras-Rodriguez O, Arnoriaga-Rodríguez M, Miranda-Olivos R, Blasco G, Biarnés C, Puig J, Rivera-Pinto J, Calle ML, Pérez-Brocal V, Moya A, Coll C, Ramió-Torrentà L, Soriano-Mas C, Fernandez-Real JM

Obesity status and obesity-associated gut dysbiosis effects on hypothalamic structural covariance

INTERNATIONAL JOURNAL OF OBESITY, 2022, 46, 30-38 dx.doi.org/10.1038/s41366-021-00953-9

Internal Medicine , Neurodegeneration and Neuroinflammation

Álvarez Bravo G, Sánchez Cirera L, Angerri Nadal M, Ramió I Torrentà L

Clinical heterogeneity in patients with myoclonus associated to COVID-19

NEUROLOGICAL SCIENCES, 2022, 43, 1587-1592 dx.doi.org/10.1007/s10072-021-05802-1

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Competitive projects

Neurodegeneration and Neuroinflammation

Ajuda de personal PERIS Claudia Coll

Codi oficial: SLT017/20/000115 Start date:01/07/2021 Data fi: 31/12/2023 Investigador/a principal: LLUÍS RAMIÓ TORRENTÀ Organisme finançador: GENERALITAT DE CATALUNYA Ajuda: 74,024.53 €

Neurodegeneration and Neuroinflammation

RICORS - Enfermedades Inflamatorias

Codi oficial: RD21/0002/0063 - EM Start date:01/01/2022 Data fi: 31/12/2024 Investigador/a principal: LLUÍS RAMIÓ TORRENTÀ Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 136,744.30 €

Neurodegeneration and Neuroinflammation

Estudio de biomarcadores moleculares de resiliencia cognitiva en el envejecimiento cerebral y en la neurodegeneración

Codi oficial: Estudio de biomarcadores moleculares neurodegeneración Start date:01/01/2022 Data fi: 31/12/2023 Investigador/a principal: LLUÍS RAMIÓ TORRENTÀ Organisme finançador: FRANCISCO SORIA MELGUIZO, S.A Ajuda: 325,600 €

Neurodegeneration and Neuroinflammation

Ajuts per donar suport a les activitats dels grups de recerca de Catalunya (SGR-Cat 2021) - Neurodegeneració i neuroinflamació

Codi oficial: HZ16YWZ3K Start date:01/01/2023 Data fi: 31/12/2024 Investigador/a principal: LLUÍS RAMIÓ TORRENTÀ Organisme finançador: AGENCIA DE GESTIO D'AJUTS UNIV. I RECER. Ajuda: 0 €

Neurodegeneration and Neuroinflammation

EM-Line! Kids: rehabilitació cognitiva des de casa per a pacients en edat pediàtrica.

Codi oficial: JBTC63KHB Start date:12/10/2022 Data fi: 11/07/2023 Investigador/a principal: JORDI GICH FULLÀ Organisme finançador: AGENCIA DE GESTIO D'AJUTS UNIV. I RECER. Ajuda: 20,000 €

Neurodegeneration and Neuroinflammation

Estudio piloto sobre los efectos del tratamiento con Calcitriol en la función neurológica y los niveles de Frataxina en pacientes con ataxia de Friedreich

Codi oficial: FA-calcitriol (ATAXIES) Start date:02/12/2020 Data fi: 30/06/2023 Investigador/a principal: BERTA ALEMANY PERNA Organisme finançador: FEDERACIÓN DE ATAXIAS DE ESPAÑA Ajuda: 6,000 €

Transfer

Clinical Guidelines

Guies mèdiques de la Societat Catalana de Neurologia: Diagnòstic i tractament de l’Esclerosi Múltiple. Societat Catalana de Neurologia.
Autors: Lluís Ramió-Torrentà, René Robles, Gary Alvarez, etc. 2020

Merchan-Ruiz M, González-del-Rio M, Ramió-Torrentà L, Del Olmo M, Vilalta T. Guia Sala de tractaments UNIEM-TG. Institut
d'Assistència Sanitària. 2020

Job offers

Falls Predict Acute Hospitalization in Parkinson's Disease.

miRNA Signature in CSF From Patients With Primary Progressive Multiple Sclerosis.

Changes in Principal Caregiver Mood Affects the Mood of the Parkinson's Disease Patient: The Vicious Cycle of Illness.

Association of Serum Neurofilament Light Chain Levels at Disease Onset With Disability Worsening in Patients With a First Demyelinating Multiple Sclerosis Event Not Treated With High-Efficacy Drugs.

Association of Time of Day With Outcomes Among Patients Triaged for a Suspected Severe Stroke in Nonurban Catalonia.

Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson's Disease.

Deep Intronic FGF14 GAA Repeat Expansion in Late-Onset Cerebellar Ataxia.

Treatment of multiple sclerosis with rituximab: A Spanish multicenter experience.

Obesity status and obesity-associated gut dysbiosis effects on hypothalamic structural covariance

Clinical heterogeneity in patients with myoclonus associated to COVID-19

Clinical Guidelines

Team

Group leader - R4

Established researchers - R3

Postdoctorals researchers – R2

Predoctorals researchers – R1

Collaborators

Non-scientific research support staff

Research technicians

Others

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