Neurodegeneration and Neuroinflammation

The Neurodegeneration and Neuroimflammation group’s mission is to work in a multidisciplinary, coordinated and translational way to increase knowledge of neurodegenerative and neuroinflammatory diseases to respond to the needs and demands of those suffering from them and their families.

Main lines of research

Clinical-care priority lines:

Study of neuropsychological alterations and cognitive rehabilitation in multiple sclerosis.
Study of the emotional impact, coping and adaptation to the diagnosis of multiple sclerosis.
Improvement of the adherence to immunomodulatory treatment in multiple sclerosis.
Use of a multi-parametric, multi-user and multi-functional database for multiple sclerosis.
Implementation of the use of electronic devices to assess disability in patients with multiple sclerosis.
Application of new cranial MR techniques as prognosis markers in multiple sclerosis.
Computer assisted systematization of lesions seen on cranial MRIs in patients with multiple sclerosis.
Application and integration of information technologies in assistance activity and research in multiple sclerosis.
Treatment of orphans in hereditary ataxia.

Priority lines in basic research:

Study of the profiles of specific miRNAs for different clinical forms and progressions of multiple sclerosis.
Study of the DNA methylation profile of patients with multiple sclerosis.
Study of the molecular mechanisms associated to neurodegeneration.
Study of the progression of cognitive function biomarkers in patients with multiple sclerosis.
Determination of biological factors (genetic and biochemical) in response to immunomodulatory treatments in multiple sclerosis.
Study of the intestinal microbes in Parkinson’s disease and other neurodegenerative diseases.
Bank of DNA, CSF, and serum samples for neuroimmunology diseases.

Strategic objectives

To be the reference group in the province of Girona in research and teaching in multiple sclerosis and other diseases
To have a national and international presence in the area of research in multiple sclerosis
To consolidate clinical research into multiple sclerosis
To consolidate basic research into multiple sclerosis
To promote and lead research into new treatments for multiple sclerosis
To begin clinical research into Parkinson’s disease and other movement disorders
To begin clinical research into Alzheimer’s and other dementias
To consolidate clinical research into hereditary ataxia
To lead research into neuropsychology of multiple sclerosis on a national level
To establishing research collaborations with other national and international groups for multiple sclerosis
To promote research into multiple sclerosis in nursing and neuropsychology
To promote training and teaching in multiple sclerosis, Parkinson’s disease, hereditary ataxia and dementias for health professionals, specialists and affected patients and relatives alike
Technological innovation in multiple sclerosis and other neurodegenerative diseases

Publications

Cerebrovascular Pathology , Neurodegeneration and Neuroinflammation

Flores A, Garcia-Tornel A, Seró L, Ustrell X, Requena M, Pellisé A, Rodriguez P, Monterde A, Lara L, Gonzalez-de-Echavarri JM, Molina CA, Doncel-Moriano A, Dorado L, Cardona P, Cánovas D, Krupinski J, Más N, Purroy F, Zaragoza-Brunet J, Palomeras E, Cocho D, Garcia J, Colom C, Silva Y, Gomez-Cocho M, Jiménez X, Ros-Roig J, Abilleira S, Pérez de la Ossa N, Ribo M

Influence of vascular imaging acquisition at local stroke centers on workflows in the drip-n-ship model: a RACECAT post hoc analysis

JOURNAL OF NEUROINTERVENTIONAL SURGERY, 2024, 16, 143-150 dx.doi.org/10.1136/jnis-2023-020125

Neurodegeneration and Neuroinflammation

Gich J, Salavedra-Pont J, Coll-Martinez C, Quintana E, Álvarez-Bravo G, Robles-Cedeño R, Buxó M, Contreras-Rodriguez O, Ramió-Torrentà L

The nature of memory impairment in multiple sclerosis: understanding different patterns over the course of the disease

Frontiers in Psychology, 2024, 14, 1269794-1269794 dx.doi.org/10.3389/fpsyg.2023.1269794

Nutrition, Eumetabolism and Health , Neurodegeneration and Neuroinflammation , Medical Imaging , Research in Vascular Health , Integrative Systems Medicine and Biology

Rosell-Díaz M, Santos-González E, Motger-Albertí A, Gallardo-Nuell L, Arnoriaga-Rodríguez M, Coll-Martínez C, Ramió-Torrentà L, Garre-Olmo J, Puig J, Ramos R, Mayneris-Perxachs J, Manuel Fernández-Real J

Lower serum ferritin levels are associated with worse cognitive performance in aging

JOURNAL OF NUTRITION HEALTH & AGING, 2024, 28, 100190-100190 dx.doi.org/10.1016/j.jnha.2024.100190

Medical Imaging , Nutrition, Eumetabolism and Health , Neurodegeneration and Neuroinflammation

Motger-Albertí A, de la Calle E, Giménez M, Blasco G, Biarnés C, Arnoriaga-Rodríguez M, Puig J, Coll-Martínez C, Contreras-Rodríguez O, Fernández-Real JM

Increased brain fractional perfusion in obesity using intravoxel incoherent motion (IVIM) MRI metrics

Obesity, 2024, 32, 756-767 dx.doi.org/10.1002/oby.24001

Neurodegeneration and Neuroinflammation

Alemany-Perna, B, Tamarit, J, Cabiscol, E, Delaspre, F, Miguela, A, Huertas-Pons, JM, Quiroga-Varela, A, Ruiz, MM, Dominguez, DL, Torrenta, L, Genis, D, Ros, J

Calcitriol Treatment Is Safe and Increases Frataxin Levels in Friedreich Ataxia Patients

MOVEMENT DISORDERS, 2024, 39, 1099-1108 dx.doi.org/10.1002/mds.29808

Neurodegeneration and Neuroinflammation

Fernández, OF, Costa-Frossard, L, Ginés, MLM, Escribano, PM, González, JMP, Ramió-Torrentà, L, Aladro, Y, Torres, AA, Rodríguez, EA, Labiano-Fontcuberta, A, Pascual, LL, Martínez, AM, Torres, EM, Oliva-Nacarino, P

Practical tool to identify Spasticity-Plus Syndrome amongst patients with multiple sclerosis. Algorithm development based on a conjoint analysis

Frontiers in Neurology, 2024, 15 dx.doi.org/10.3389/fneur.2024.1371644

Neurodevelopmental disorders , Neurodegeneration and Neuroinflammation , Cardiovascular Genetics

Mademont-Soler I, Esteba-Castillo S, Jiménez-Xifra A, Alemany B, Ribas-Vidal N, Cutillas M, Coll M, Pinsach ML, Pagans S, Alcalde M, Viñas-Jornet M, Montero-Vale M, de Castro-Miró M, Rodríguez J, Armengol L, Queralt X, Obón M

Unexpected complexity in the molecular diagnosis of spastic paraplegia 11.

Molecular genetics & genomic medicine, 2024, 12, 2475-2475 dx.doi.org/10.1002/mgg3.2475

Nutrition, Eumetabolism and Health , Neurodegeneration and Neuroinflammation , Medical Imaging , Integrative Systems Medicine and Biology , Research in Vascular Health

Rosell-Díaz M, Petit-Gay A, Molas-Prat C, Gallardo-Nuell L, Ramió-Torrentà L, Garre-Olmo J, Pérez-Brocal V, Moya A, Jové M, Pamplona R, Puig J, Ramos R, Bäckhed F, Mayneris-Perxachs J, Fernández-Real JM

Metformin-induced changes in the gut microbiome and plasma metabolome are associated with cognition in men.

METABOLISM-CLINICAL AND EXPERIMENTAL, 2024, 157, 155941-155941 dx.doi.org/10.1016/j.metabol.2024.155941

Neurodegeneration and Neuroinflammation

Tortosa-Carreres J, Cubas-Núñez L, Quiroga-Varela A, Castillo-Villalba J, Ramió-Torrenta L, Piqueras M, Gasqué-Rubio R, Quintanilla-Bordas C, Sanz MT, Lucas C, Huertas-Pons JM, Miguela A, Casanova B, Laiz-Marro B, Pérez-Miralles FC

Predictive potential of serum and cerebrospinal fluid biomarkers for disease activity in treated multiple sclerosis patients.

MULTIPLE SCLEROSIS AND RELATED DISORDERS, 2024, 88, 105734-105734 dx.doi.org/10.1016/j.msard.2024.105734

Neurodegeneration and Neuroinflammation

Dominguez-Mozo MI, Galán V, Ramió-Torrentà L, Quiroga A, Quintana E, Villar LM, Costa-Frossard L, Fernández-Velasco JI, Villarrubia N, Garcia-Martinez MA, Arroyo R, Alvarez-Lafuente R

A two-years real-word study with fingolimod: early predictors of efficacy and an association between EBNA-1 IgG titers and multiple sclerosis progression.

Frontiers in Immunology, 2024, 15, 1384411-1384411 dx.doi.org/10.3389/fimmu.2024.1384411

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Competitive projects

Neurodegeneration and Neuroinflammation

Estudio de biomarcadores moleculares de resiliencia cognitiva en el envejecimiento cerebral y en la neurodegeneración

Codi oficial: Estudio de biomarcadores moleculares neurodegeneración Start date:01/01/2022 Data fi: 31/12/2024 Investigador/a principal: LLUÍS RAMIÓ TORRENTÀ Organisme finançador: FRANCISCO SORIA MELGUIZO, S.A

Neurodegeneration and Neuroinflammation

Ajuts per donar suport a les activitats dels grups de recerca de Catalunya (SGR-Cat 2021) - Neurodegeneració i neuroinflamació

Codi oficial: HZ16YWZ3K Start date:01/01/2022 Data fi: 30/06/2025 Investigador/a principal: LLUÍS RAMIÓ TORRENTÀ Organisme finançador: AGÈNCIA DE GESTIÓ UNIVERSITARIS I RECERCA (AGAUR)

Neurodegeneration and Neuroinflammation

PROCOGBIO Predicción de la progresión del deterioro cognitivo en la esclerosis múltiple combinando biomarcadores circulantes en sangre

Codi oficial: PI23/00517 Start date:01/01/2024 Data fi: 31/12/2026 Investigador/a principal: ANNA QUIROGA VARELA, LLUÍS RAMIÓ TORRENTÀ Organisme finançador: INSTITUTO DE SALUD CARLOS III

Neurodegeneration and Neuroinflammation

Estudio piloto sobre los efectos del tratamiento con Calcitriol en la función neurológica y los niveles de Frataxina en pacientes con ataxia de Friedreich

Codi oficial: FA-calcitriol (ATAXIES) Start date:02/12/2020 Data fi: 30/11/2024 Investigador/a principal: BERTA ALEMANY PERNA Organisme finançador: FEDERACIÓN DE ATAXIAS DE ESPAÑA

Neurodegeneration and Neuroinflammation

Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS) - Enfermedades Inflamatorias

Codi oficial: RD21/0002/0063 - EM Start date:01/01/2022 Data fi: 31/12/2024 Investigador/a principal: LLUÍS RAMIÓ TORRENTÀ Organisme finançador: INSTITUTO DE SALUD CARLOS III

Transfer

Clinical Guidelines

Guies mèdiques de la Societat Catalana de Neurologia: Diagnòstic i tractament de l’Esclerosi Múltiple. Societat Catalana de Neurologia.
Autors: Lluís Ramió-Torrentà, René Robles, Gary Alvarez, etc. 2020

Merchan-Ruiz M, González-del-Rio M, Ramió-Torrentà L, Del Olmo M, Vilalta T. Guia Sala de tractaments UNIEM-TG. Institut
d'Assistència Sanitària. 2020

Job offers

Influence of vascular imaging acquisition at local stroke centers on workflows in the drip-n-ship model: a RACECAT post hoc analysis

The nature of memory impairment in multiple sclerosis: understanding different patterns over the course of the disease

Lower serum ferritin levels are associated with worse cognitive performance in aging

Increased brain fractional perfusion in obesity using intravoxel incoherent motion (IVIM) MRI metrics

Calcitriol Treatment Is Safe and Increases Frataxin Levels in Friedreich Ataxia Patients

Practical tool to identify Spasticity-Plus Syndrome amongst patients with multiple sclerosis. Algorithm development based on a conjoint analysis

Unexpected complexity in the molecular diagnosis of spastic paraplegia 11.

Metformin-induced changes in the gut microbiome and plasma metabolome are associated with cognition in men.

Predictive potential of serum and cerebrospinal fluid biomarkers for disease activity in treated multiple sclerosis patients.

A two-years real-word study with fingolimod: early predictors of efficacy and an association between EBNA-1 IgG titers and multiple sclerosis progression.

Clinical Guidelines

Team

Group leader - R4

Established researchers - R3

Predoctorals researchers – R1

Collaborators

Non-scientific research support staff

Research technicians

Emeritus researcher

Nurse

About IDIBGI!