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The Neurodegeneration and Neuroimflammation group’s mission is to work in a multidisciplinary, coordinated and translational way to increase knowledge of neurodegenerative and neuroinflammatory diseases to respond to the needs and demands of those suffering from them and their families.

Main lines of research

Clinical-care priority lines:

  • Study of neuropsychological alterations and cognitive rehabilitation in multiple sclerosis.
  • Study of the emotional impact, coping and adaptation to the diagnosis of multiple sclerosis.
  • Improvement of the adherence to immunomodulatory treatment in multiple sclerosis.
  • Use of a multi-parametric, multi-user and multi-functional database for multiple sclerosis.
  • Implementation of the use of electronic devices to assess disability in patients with multiple sclerosis.
  • Application of new cranial MR techniques as prognosis markers in multiple sclerosis.
  • Computer assisted systematization of lesions seen on cranial MRIs in patients with multiple sclerosis.
  • Application and integration of information technologies in assistance activity and research in multiple sclerosis.
  • Treatment of orphans in hereditary ataxia.

 

Priority lines in basic research:

  • Study of the profiles of specific miRNAs for different clinical forms and progressions of multiple sclerosis.
  • Study of the DNA methylation profile of patients with multiple sclerosis.
  • Study of the molecular mechanisms associated to neurodegeneration.
  • Study of the progression of cognitive function biomarkers in patients with multiple sclerosis.
  • Determination of biological factors (genetic and biochemical) in response to immunomodulatory treatments in multiple sclerosis.
  • Study of the intestinal microbes in Parkinson’s disease and other neurodegenerative diseases.
  • Bank of DNA, CSF, and serum samples for neuroimmunology diseases.
Strategic objectives
  • To be the reference group in the province of Girona in research and teaching in multiple sclerosis and other diseases
  • To have a national and international presence in the area of research in multiple sclerosis
  • To consolidate clinical research into multiple sclerosis
  • To consolidate basic research into multiple sclerosis
  • To promote and lead research into new treatments for multiple sclerosis
  • To begin clinical research into Parkinson’s disease and other movement disorders
  • To begin clinical research into Alzheimer’s and other dementias
  • To consolidate clinical research into hereditary ataxia
  • To lead research into neuropsychology of multiple sclerosis on a national level
  • To establishing research collaborations with other national and international groups for multiple sclerosis
  • To promote research into multiple sclerosis in nursing and neuropsychology
  • To promote training and teaching in multiple sclerosis, Parkinson’s disease, hereditary ataxia and dementias for health professionals, specialists and affected patients and relatives alike
  • Technological innovation in multiple sclerosis and other neurodegenerative diseases
Publications
Pellerin D, Méreaux JL, Boluda S, Danzi MC, Dicaire MJ, Davoine CS, Genis D, Spurdens G, Ashton C, Hammond JM, Gerhart BJ, Chelban V, Le PU, Safisamghabadi M, Yanick C, Lee H, Nageshwaran SK, Matos-Rodrigues G, Jaunmuktane Z, Petrecca K, Akbarian S, Nussenzweig A, Usdin K, Renaud M, Bonnet C, Ravenscroft G, Saporta MA, Napierala JS, Houlden H, Deveson IW, Napierala M, Brice A, Molina Porcel L, Seilhean D, Zuchner S, Durr A, Brais B

Somatic instability of the FGF14-SCA27B GAA•TTC repeat reveals a marked expansion bias in the cerebellum.

Brain, 2025, 148, 1258-1270 dx.doi.org/10.1093/brain/awae312
Villacieros-alvarez, J, Lunemann, JD, Sepulveda, M, Valls-Carbó, A, Dinoto, A, Fernández, V, Vilaseca, A, Castillo, M, Arrambide, G, Bollo, L, Espejo, C, Llufriu, S, Blanco, Y, Armangue, T, Bravo, GA, Quiroga-Varela, A, Torrenta, LR, Cobo-Calvo, A, Tintore, M, Mariotto, S, Montalban, X, Comabella, M

Complement Activation Profiles Predict Clinical Outcomes in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION, 2025, 12 dx.doi.org/10.1212/NXI.0000000000200340
López Domínguez D, Alemany Perna B, Álvarez Bravo G

Late-onset chorea as first manifestation of cerebral amyloid angiopathy.

PARKINSONISM & RELATED DISORDERS, 2025, 131, 107225-107225 dx.doi.org/10.1016/j.parkreldis.2024.107225
Fumagalli, A, Castells-Nobau, A, Trivedi, D, Garre-Olmo, J, Puig, J, Ramos, R, Ramió-Torrentà, L, Pérez-Brocal, V, Moya, A, Swann, J, Martin-Garcia, E, Maldonado, R, Fernández-Real, JM, Mayneris-Perxachs, J

Archaea methanogens are associated with cognitive performance through the shaping of gut microbiota, butyrate and histidine metabolism

Gut Microbes, 2025, 17, 2455506-2455506 dx.doi.org/10.1080/19490976.2025.2455506
Marignier R, Villacieros-Álvarez J, Espejo C, Arrambide G, Fissolo N, Gutiérrez L, Dinoto A, Mulero P, Rubio-Flores L, Nieto P, Alcalá C, Meca-Lallana JE, Martínez-Garcia P, Millán J, Bernard-Valnet R, González I, Orvíz García A, Tellez R, Navarro L, Presas-Rodríguez S, Romero-Pinel L, Martínez-Yélamos S, Cuello JP, Alonso Torres AM, Piñar R, Álvarez Bravo G, Benyahya L, Trouillet-Assant S, Dyon-Tafani V, Froment Tilikete C, Ruet A, Bourre B, Deschamps R, Papeix C, Maillart E, Kerschen P, Ayrignac X, Rovira A, Auger C, Audoin B, Montalban X, Tintore M, Mariotto S, Cobo-Calvo A

Assessment of neuronal and glial serum biomarkers in myelin oligodendrocyte glycoprotein antibody-associated disease: the MULTIMOGAD study.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2025 dx.doi.org/10.1136/jnnp-2024-335137
Santos-García D, de Deus Fonticoba T, Jesús S, Cosgaya M, García Caldentey J, Caballol N, Legarda I, Hernández Vara J, Cabo I, López Manzanares L, González Aramburu I, Ávila Rivera MA, Gómez Mayordomo V, Nogueira V, Dotor García-Soto J, Borrué C, Solano Vila B, Álvarez Sauco M, Vela L, Escalante S, Cubo E, Mendoza Z, Pareés I, Sánchez Alonso P, Alonso Losada MG, López Ariztegui N, Gastón I, Kulisevsky J, Seijo M, Valero C, Alonso Redondo R, Ordás C, Menéndez-González M, McAfee D, Martinez-Martin P, Mir P

Dysphagia in Parkinson´s disease. A 5-year follow-up study.

NEUROLOGICAL SCIENCES, 2025 dx.doi.org/10.1007/s10072-025-08027-8
Genís, D, Alemany, B, Pellerin, D, Brais, B, Dicaire, MJ, Volpini, V, Campos, B, Corral, J, Gardenyes, J, de Jorge, L, San Nicolás, H, Buxó, M, Sancho, JM, Obon, M, Roig, C, Rodriguez-Revenga, L, Alvarez-Mora, MI, Danzi, MC, Houlden, H, Zuchner, S, Márquez, F, Torrenta, LRI

Late-onset vestibulocerebellar ataxia: clinical and genetic studies in a long follow-up series of 50 patients

JOURNAL OF NEUROLOGY, 2025, 272, 235-235 dx.doi.org/10.1007/s00415-025-12964-x
Rodríguez-Antigüedad J, Martínez-Horta S, Puig-Davi A, Horta-Barba A, Pagonabarraga J, de Deus Fonticoba T, Jesús S, Cosgaya M, García Caldentey J, Ávila-Rivera MA, Caballol N, Legarda I, Hernández Vara J, Cabo I, López Manzanares L, González Aramburu I, Gómez Mayordomo V, González Ardura J, Dotor García-Soto J, Borrué C, Solano Vila B, Álvarez Sauco M, Vela L, Escalante S, Cubo E, Mendoza Z, Pareés I, Sánchez Alonso P, Alonso Losada MG, López Ariztegui N, Gastón I, Ruíz Martínez J, Buongiorno MT, Ordás C, Valero C, Puente V, Kurtis M, Blázquez Estrada M, Martínez-Martín P, Mir P, Santos-García D, Kulisevsky J

Heterogeneity of cognitive progression and clinical predictors in Parkinson's disease-subjective cognitive decline.

JOURNAL OF NEUROLOGY, 2025, 272, 246-246 dx.doi.org/10.1007/s00415-024-12808-0
Rodríguez-Antigüedad J, Martínez-Horta S, Puig-Davi A, Horta-Barba A, Pagonabarraga J, de Deus Fonticoba T, Jesús S, Cosgaya M, García Caldentey J, Ávila-Rivera MA, Caballol N, Legarda I, Hernández Vara J, Cabo I, López Manzanares L, González Aramburu I, Gómez Mayordomo V, González Ardura J, Dotor García-Soto J, Borrué C, Solano Vila B, Álvarez Sauco M, Vela L, Escalante S, Cubo E, Mendoza Z, Pareés I, Sánchez Alonso P, Alonso Losada MG, López Ariztegui N, Gastón I, Ruíz Martínez J, Buongiorno MT, Ordás C, Valero C, Puente V, Kurtis M, Blázquez Estrada M, Martínez-Martín P, Mir P, Santos-García D, Kulisevsky J

Correction: Heterogeneity of cognitive progression and clinical predictors in Parkinson's disease-subjective cognitive decline.

JOURNAL OF NEUROLOGY, 2025, 272, 362-362 dx.doi.org/10.1007/s00415-025-13077-1
Serrano-Munuera C, Martínez-Regueiro R, Martínez Fernández EM, Alemany Perna B, López Domínguez D, Rojas-Bartolomé L, Gómez AA, Pérez Torre P, Abenza Abildúa MJ, Rouco Axpe I, Feria-Vilar I, Pérez Pérez J, Schmahmann JD, García-Sánchez C

Validation of the Spanish version of the cerebellar cognitive-affective syndrome scale.

CLINICAL NEUROPSYCHOLOGIST, 2025, 1-17 dx.doi.org/10.1080/13854046.2025.2488453
Competitive projects
Neurodegeneration and Neuroinflammation

Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS) - Enfermedades Inflamatorias

Codi oficial: RD21/0002/0063 - EM Start date:01/01/2022 Data fi: 31/12/2025 Investigador/a principal: LLUÍS RAMIÓ TORRENTÀ Organisme finançador: INSTITUTO DE SALUD CARLOS III
Neurodegeneration and Neuroinflammation

Estudio de biomarcadores moleculares de resiliencia cognitiva en el envejecimiento cerebral y en la neurodegeneración

Codi oficial: Estudio de biomarcadores moleculares neurodegeneración Start date:01/01/2022 Data fi: 30/06/2025 Investigador/a principal: LLUÍS RAMIÓ TORRENTÀ Organisme finançador: FRANCISCO SORIA MELGUIZO, S.A
Neurodegeneration and Neuroinflammation

Ajuts per donar suport a les activitats dels grups de recerca de Catalunya (SGR-Cat 2021) - Neurodegeneració i neuroinflamació

Codi oficial: 2021 SGR 01616 Start date:01/01/2022 Data fi: 30/06/2025 Investigador/a principal: LLUÍS RAMIÓ TORRENTÀ Organisme finançador: AGÈNCIA DE GESTIÓ UNIVERSITARIS I RECERCA
Neurodegeneration and Neuroinflammation

Red Española de Esclerosis Múltiple

Codi oficial: RED2022-134425-T Start date:01/06/2023 Data fi: 31/05/2025 Investigador/a principal: LLUÍS RAMIÓ TORRENTÀ, GARY CICERÓN ÁLVAREZ BRAVO Organisme finançador: MINISTERIO DE ECONOMIA E INNOVACION
Neurodegeneration and Neuroinflammation

PROCOGBIO Predicción de la progresión del deterioro cognitivo en la esclerosis múltiple combinando biomarcadores circulantes en sangre

Codi oficial: PI23/00517 Start date:01/01/2024 Data fi: 31/12/2026 Investigador/a principal: ANNA QUIROGA VARELA, LLUÍS RAMIÓ TORRENTÀ Organisme finançador: INSTITUTO DE SALUD CARLOS III
Neurodegeneration and Neuroinflammation

Prediciendo la Progresión del Deterioro Cognitivo en la Esclerosis Múltiple a través de biomarcadores circulantes en sangre (COGNIPROG)

Codi oficial: COGNIPROG Start date:01/09/2023 Data fi: 31/12/2025 Investigador/a principal: LLUÍS RAMIÓ TORRENTÀ Organisme finançador: ASOCIACIÓN ESCLEROSIS MULTIPLE ESPAÑA (AEDEM)
Neurodegeneration and Neuroinflammation

A RANDOMIZED CONTROLLED CLINICAL TRIAL TO EVALUATE THE MS-LINE! COGNITIVE REHABILITATION PROGRAM FOR PEOPLE WITH MS

Codi oficial: ECTRIMS2024: 344 Start date:23/09/2024 Data fi: 22/09/2025 Investigador/a principal: LLUÍS RAMIÓ TORRENTÀ, ÓSCAR DANIEL AYALA NARIÑO Organisme finançador: EUROPEAN COMMITTEE FOR TREATMENT AND RESEARCH IN MULTIPLE SCLEROSIS
Neurodegeneration and Neuroinflammation

EM-Line!Kids: rehabilitació cognitiva des de casa per a pacients en edat pediàtrica.

Codi oficial: 2024 PROD 00183 Start date:02/12/2024 Data fi: 01/06/2026 Investigador/a principal: JORDI GICH FULLÀ Organisme finançador: AGÈNCIA DE GESTIÓ UNIVERSITARIS I RECERCA
Neurodegeneration and Neuroinflammation

Red de Enfermedades Inflamatorias (REI)

Codi oficial: RD24/0007/0005 Start date:01/01/2025 Data fi: 31/12/2027 Investigador/a principal: LLUÍS RAMIÓ TORRENTÀ Organisme finançador: INSTITUTO DE SALUD CARLOS III
Neurodegeneration and Neuroinflammation

Terapia Génica para la Ataxia de Friedreich

Codi oficial: CPP2023-010463 Start date:01/09/2024 Data fi: 31/08/2027 Investigador/a principal: BERTA ALEMANY PERNA Organisme finançador: MINISTERIO DE ECONOMIA E INNOVACION
Neurodegeneration and Neuroinflammation

Adaptació i validació del “Multiple Sclerosis Health Literacy Questionnaire” a la població espanyola diagnosticada d’esclerosi múltiple

Codi oficial: SLT035/24/000010 Start date:02/01/2025 Data fi: 01/01/2027 Investigador/a principal: MARINA GONZALEZ DEL RIO Organisme finançador: GENERALITAT DE CATALUNYA
Neurodegeneration and Neuroinflammation

Ayuda de personal Miguel Servet

Codi oficial: CP24/00018 Start date:01/01/2025 Data fi: 31/12/2029 Investigador/a principal: ANNA QUIROGA VARELA Organisme finançador: INSTITUTO DE SALUD CARLOS III
Neurodegeneration and Neuroinflammation

Ayuda de proyecto Miguel Servet

Codi oficial: CP24/00018 Projecte Start date:01/01/2025 Data fi: 31/12/2028 Investigador/a principal: ANNA QUIROGA VARELA Organisme finançador: INSTITUTO DE SALUD CARLOS III
Transfer
Clinical Guidelines

Guies mèdiques de la Societat Catalana de Neurologia: Diagnòstic i tractament de l’Esclerosi Múltiple. Societat Catalana de Neurologia.
Autors: Lluís Ramió-Torrentà, René Robles, Gary Alvarez, etc. 2020

Merchan-Ruiz M, González-del-Rio M, Ramió-Torrentà L, Del Olmo M, Vilalta T. Guia Sala de tractaments UNIEM-TG. Institut
d'Assistència Sanitària. 2020

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