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The Nutrition, eumetabolism and health research group, led by Professor José Manuel Fernández-Real is made up of 12 doctors (Medicine, Biology and Engineering), 7 pre-graduate researchers, 4 endocrinologists, 3 research technicians, 2 lab technicians, 4 dieticians and 1 nurse.

Main lines of research
  • Innate immune system, inflammation and metabolic diseases
  • Type 2 genomic/genetic diabetes and obesity (including microRNA and long non-coding RNA)
  • Biology of the adipose tissue
  • Iron as a modulator of inflammation to metabolic diseases
  • The role of microbiota in obesity and type 2 diabetes
  • Non-alcoholic steatohepatitis and fatty liver
  • The brain as a metabolic organ
  • Computational tools to optimize glycaemic control
Strategic objectives
  • To study the physiopathology of obesity and comorbidities associated to diabetes mellitus and NASH/NAFLD
  • To look for better biomarkers for obesity, insulin resistance and Type-2 diabetes
  • To understand the relationship between inflammation and insulin resistance
  • To further knowledge of the metabolism of iron and insulin resistance
  • To observe the interaction between the Systems Biology and Microbiome / miRNAs / Innate immune system
  • To better understand the association between micriobiome and metabolic diseases
  • To understand the interaction between microbiota and cognitive function
  • To analyse the metabolic image
Publications
Rosell-Díaz M, Fernández-Real JM

Metformin, Cognitive Function, and Changes in the Gut Microbiome

ENDOCRINE REVIEWS, 2024, 45, 210-226 dx.doi.org/10.1210/endrev/bnad029
Moreno-Navarrete JM, Fernández-Real JM

Iron: The silent culprit in your adipose tissue

OBESITY REVIEWS, 2024, 25 dx.doi.org/10.1111/obr.13647
Valenti L, Corradini E, Adams LA, Aigner E, Alqahtani S, Arrese M, Bardou-Jacquet E, Bugianesi E, Fernandez-Real JM, Girelli D, Hagström H, Henninger B, Kowdley K, Ligabue G, McClain D, Lainé F, Miyanishi K, Muckenthaler MU, Pagani A, Pedrotti P, Pietrangelo A, Prati D, Ryan JD, Silvestri L, Spearman CW, Stål P, Tsochatzis EA, Vinchi F, Zheng MH, Zoller H

Consensus Statement on the definition and classification of metabolic hyperferritinaemia (vol 19, pg 299, 2023)

NATURE REVIEWS ENDOCRINOLOGY, 2024, 20, 168-184 dx.doi.org/10.1038/s41574-023-00940-2
Rosell-Díaz M, Santos-González E, Motger-Albertí A, Gallardo-Nuell L, Arnoriaga-Rodríguez M, Coll-Martínez C, Ramió-Torrentà L, Garre-Olmo J, Puig J, Ramos R, Mayneris-Perxachs J, Manuel Fernández-Real J

Lower serum ferritin levels are associated with worse cognitive performance in aging

JOURNAL OF NUTRITION HEALTH & AGING, 2024, 28, 100190-100190 dx.doi.org/10.1016/j.jnha.2024.100190
Motger-Albertí A, de la Calle E, Giménez M, Blasco G, Biarnés C, Arnoriaga-Rodríguez M, Puig J, Coll-Martínez C, Contreras-Rodríguez O, Fernández-Real JM

Increased brain fractional perfusion in obesity using intravoxel incoherent motion (IVIM) MRI metrics

Obesity, 2024, 32, 756-767 dx.doi.org/10.1002/oby.24001
Mayneris-Perxachs J, Castells-Nobau A, Fernández-Real JM

"Indole-gence"for the mind

CELL HOST & MICROBE, 2024, 32, 151-153 dx.doi.org/10.1016/j.chom.2024.01.006
Delfin C, Dragan I, Kuznetsov D, Tajes JF, Smit F, Coral DE, Farzaneh A, Haugg A, Hungele A, Niknejad A, Hall C, Jacobs D, Marek D, Fraser DP, Thuillier D, Ahmadizar F, Mehl F, Pattou F, Burdet F, Hawkes G, Arts ICW, Blanch J, Van Soest J, Fernández-Real JM, Boehl J, Fink K, van Greevenbroek MMJ, Kavousi M, Minten M, Prinz N, Ipsen N, Franks PW, Ramos R, Holl RW, Horban S, Duarte-Salles T, Tran VDT, Raverdy V, Leal Y, Lenart A, Pearson E, Sparsø T, Giordano GN, Ioannidis V, Soh K, Frayling TM, Le Roux CW, Ibberson M

A Federated Database for Obesity Research: An IMI-SOPHIA Study

LIFE-BASEL, 2024, 14 dx.doi.org/10.3390/life14020262
Bergheim, I, Moreno-Navarrete, JM

The relevance of intestinal barrier dysfunction, antimicrobial proteins and bacterial endotoxin in metabolic dysfunction-associated steatotic liver disease

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2024, 54 dx.doi.org/10.1111/eci.14224
Oram, RA, Grif, KJ, Tobias, DK, Merino, J, Ahmad, A, Aiken, C, Benham, JL, Bodhini, D, Clark, AL, Colclough, K, Corcoy, R, Cromer, SJ, Duan, D, Felton, JL, Francis, EC, Gillard, P, Gingras, V, Gaillard, R, Haider, E, Hughes, A, Ikle, JM, Jacobsen, LM, Kahkoska, AR, Kettunen, JLT, Kreienkamp, RJ, Lim, LL, Männistö, JME, Massey, R, Mclennan, NM, Miller, RG, Morieri, ML, Most, J, Naylor, RN, Ozkan, B, Patel, KA, Pilla, SJ, Prystupa, K, Raghavan, S, Rooney, MR, Schön, M, Semnani-Azad, Z, Sevilla-Gonzalez, M, Svalastoga, P, Takele, WW, Tam, CHT, Thuesen, ACB, Tosur, M, Wallace, AS, Wang, CC, Wong, JJ, Yamamoto, JM, Young, K, Amouyal, C, Andersen, MK, Bonham, MP, Chen, ML, Cheng, FF, Chikowore, T, Chivers, SC, Clemmensen, C, Dabelea, D, Dawed, AY, Deutsch, AJ, Dickens, LT, DiMeglio, LA, Dudenhöffer-Pfeifer, M, Evans-Molina, C, Fernández-Balsells, MM, Fitipaldi, H, Fitzpatrick, SL, Gitelman, SE, Goodarzi, MO, Grieger, JA, Guasch-Ferré, M, Habibi, N, Hansen, T, Huang, CG, Harris-Kawano, A, Ismail, HM, Hoag, B, Johnson, RK, Jones, AG, Koivula, RW, Leong, A, Leung, GKW, Libman, IM, Liu, K, Long, SA, Lowe, WL, Morton, RW, Motala, AA, Onengut-Gumuscu, S, Pankow, JS, Pathirana, M, Pazmino, S, Perez, D, Petrie, JR, Powe, CE, Quinteros, A, Jain, R, Ray, D, Ried-Larsen, M, Saeed, Z, Santhakumar, V, Kanbour, S, Sarkar, S, Monaco, GSF, Scholtens, DM, Selvin, E, Sheu, WHH, Speake, C, Stanislawski, MA, Steenackers, N, Steck, AK, Stefan, N, Stoy, J, Taylor, R, Tye, SC, Ukke, GG, Urazbayeva, M, Van der Schueren, B, Vatier, C, Wentworth, JM, Hannah, W, White, SL, Yu, GC, Zhang, YC, Zhou, SJ, Beltrand, J, Polak, M, Aukrust, I, de Franco, E, Flanagan, SE, Maloney, KA, McGovern, A, Molnes, J, Nakabuye, M, Njolstad, PR, Pomares-Millan, H, Provenzano, M, Saint-Martin, C, Zhang, CL, Zhu, YY, Auh, S, de Souza, R, Fawcett, AJ, Gruber, C, Mekonnen, EG, Mixter, E, Sherifali, D, Eckel, RH, Nolan, JJ, Philipson, LH, Brown, RJ, Billings, LK, Boyle, K, Costacou, T, Dennis, JM, Florez, JC, Gloyn, AL, Gomez, MF, Gottlieb, PA, Greeley, SAW, Griffin, K, Hattersley, AT, Hirsch, IB, Hivert, MF, Hood, KK, Josefson, JL, Kwak, SH, Laffel, LM, Lim, SS, Loos, RJF, Ma, RCW, Mathieu, C, Mathioudakis, N, Meigs, JB, Misra, S, Mohan, V, Murphy, R, Oram, R, Owen, KR, Ozanne, SE, Pearson, ER, Perng, W, Pollin, TI, Pop-Busui, R, Pratley, RE, Redman, LM, Redondo, MJ, Reynolds, RM, Semple, RK, Sherr, JL, Sims, EK, Sweeting, A, Tuomi, T, Udler, MS, Vesco, KK, Vilsboll, T, Wagner, R, Rich, SS, Franks, PW

Islet autoantibodies as precision diagnostic tools to characterize heterogeneity in type 1 diabetes: a systematic review

Communications Medicine, 2024, 4 dx.doi.org/10.1038/s43856-024-00478-y
Rosell-Díaz M, Petit-Gay A, Molas-Prat C, Gallardo-Nuell L, Ramió-Torrentà L, Garre-Olmo J, Pérez-Brocal V, Moya A, Jové M, Pamplona R, Puig J, Ramos R, Bäckhed F, Mayneris-Perxachs J, Fernández-Real JM

Metformin-induced changes in the gut microbiome and plasma metabolome are associated with cognition in men.

METABOLISM-CLINICAL AND EXPERIMENTAL, 2024, 157, 155941-155941 dx.doi.org/10.1016/j.metabol.2024.155941
Competitive projects
Codi oficial: SOPHIA Start date:09/07/2020 Data fi: 08/07/2025 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: EUROPEAN COMISSION
Codi oficial: SMARTAGE Start date:01/09/2020 Data fi: 28/02/2025 Investigador/a principal: JORDI MAYNERIS PERXACHS, JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: EUROPEAN COMISSION
Codi oficial: SLT017/20/000164 Start date:12/07/2021 Data fi: 31/12/2024 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: GENERALITAT DE CATALUNYA
Codi oficial: PI21/01361 Start date:01/01/2022 Data fi: 31/12/2024 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: INSTITUTO DE SALUD CARLOS III
Codi oficial: PMP21/00072 Start date:01/01/2022 Data fi: 31/12/2025 Investigador/a principal: JORDI MAYNERIS PERXACHS, JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: INSTITUTO DE SALUD CARLOS III
Codi oficial: HR22-00737 Start date:01/10/2022 Data fi: 30/09/2025 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: FUNDACIÓN BANCARIA LA CAIXA
Codi oficial: INT22/00015 Start date:01/01/2023 Data fi: 31/12/2024 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: INSTITUTO DE SALUD CARLOS III
Codi oficial: 2021 SGR 01263 Start date:01/01/2022 Data fi: 30/06/2025 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: AGÈNCIA DE GESTIÓ UNIVERSITARIS I RECERCA (AGAUR)
Codi oficial: RED2022-134313-T Start date:01/06/2023 Data fi: 31/05/2025 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: MINISTERIO DE ECONOMIA Y COMPETITIVIDAD MINECO /
Codi oficial: SLT028/23/000133 Start date:01/08/2023 Data fi: 31/12/2025 Investigador/a principal: FRANCISCO JOSÉ ORTEGA DELGADO, JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: GENERALITAT DE CATALUNYA
Codi oficial: PT23/00089 Start date:01/01/2024 Data fi: 31/12/2026 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: INSTITUTO DE SALUD CARLOS III
Codi oficial: PID2022-143113OB-I00 Start date:01/01/2024 Data fi: 31/12/2027 Investigador/a principal: JOSE MARIA MORENO NAVARRETE Organisme finançador: MINISTERIO DE ECONOMIA Y COMPETITIVIDAD MINECO /
Codi oficial: PREP2022-000811 Start date:01/02/2024 Data fi: 31/01/2028 Investigador/a principal: JOSE MARIA MORENO NAVARRETE Organisme finançador: MINISTERIO DE ECONOMIA Y COMPETITIVIDAD MINECO /
Codi oficial: MS19/00109 Start date:01/01/2020 Data fi: 22/04/2025 Investigador/a principal: FRANCISCO JOSÉ ORTEGA DELGADO Organisme finançador: INSTITUTO DE SALUD CARLOS III
Codi oficial: PI21/00074 Start date:01/01/2022 Data fi: 31/12/2024 Investigador/a principal: FRANCISCO JOSÉ ORTEGA DELGADO Organisme finançador: INSTITUTO DE SALUD CARLOS III
Codi oficial: CNS2023-145394 Start date:01/04/2024 Data fi: 30/06/2026 Investigador/a principal: FRANCISCO JOSÉ ORTEGA DELGADO Organisme finançador: MINISTERIO DE ECONOMIA Y COMPETITIVIDAD MINECO /
Transfer
Patents

Lelouvier Benjamin, Servant Florence, Courtney Michael, Federici Massimo, Fernandez-Real Jose Manuel
METHOD FOR DIAGNOSING HEPATIC FIBROSIS BASED ON BACTERIAL PROFILE AND DIVERSITY
Número de publicació: WO2017060039
Data de publicació: 2018-08-15

Burcelin Rémy, Federici Massimo, Hoyles Lesley, Dumas Marc-Emmanuel, Barton Richard Hadlow, Fernandez-Real José Manuel
METHODS FOR DETERMINING WHETHER A SUBJECT HAS OR IS AT RISK OF HAVING A NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) OR ONE OF ITS COMPLICATIONS
Número de publicació: WO2019077125
Data de publicació: 2019-04-25

Courtney Michael, Lelouvier Benjamin, Federici Massimo, Fernandez-Real Jose Manuel, Païssé Sandrine
METHOD FOR DIAGNOSING HEPATIC FIBROSIS
Número de publicació: WO2015162200
Data de publicació: 2015-10-29

Rafael Maldonado; Aureliju Burokas; Andrés Moya; Vicente Pérez; José Manuel Fernández-Real; Jordi Mayneris; María Arnoriaga.
GUT MICROBIOTA COMPOSITION AND USES THEREOF
Número de publicació: WO2022003059
Data de publicació: 2022-01-06

José Manuel Fernández-Real; José María Moreno Navarrete; Ramón Díaz; Kiyoshi Tachikawa; Priya Kamali; Rajesh Mukthavaram; Padmanabh Chivukula; Aleix Gavaldà; Marta Giralt; Francesc Villarroya.
COMPOSITIONS AND METHODS FOR TREATING METABOLIC DISORDERS
Número de sol·licitud: PCT/US21/65757

Rafael Maldonado; Andrés Moya; Vicente Pérez; José Manuel Fernández-Real; Jordi Mayneris; María Arnoriaga; Anna Castells.
BACTERIÓFAGO PARA USO TERAPÉUTICO
Número de sol·licitud: P202130786

 

Guies clíniques

- “Estrategia en diabetes del Sistema Nacional de Salud- Visión esquemática de la actualización de 2012” Informes, Estudios e Investigación 2014. Ministerios de Sanidad, Servicios Sociales e Igualdad. Wifredo Ricart

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