Menu
Fechar
hrs4r
 I want to donate

The Nutrition, eumetabolism and health research group, led by Professor José Manuel Fernández-Real is made up of 12 doctors (Medicine, Biology and Engineering), 7 pre-graduate researchers, 4 endocrinologists, 3 research technicians, 2 lab technicians, 4 dieticians and 1 nurse.

Main lines of research
  • Innate immune system, inflammation and metabolic diseases
  • Type 2 genomic/genetic diabetes and obesity (including microRNA and long non-coding RNA)
  • Biology of the adipose tissue
  • Iron as a modulator of inflammation to metabolic diseases
  • The role of microbiota in obesity and type 2 diabetes
  • Non-alcoholic steatohepatitis and fatty liver
  • The brain as a metabolic organ
  • Computational tools to optimize glycaemic control
Strategic objectives
  • To study the physiopathology of obesity and comorbidities associated to diabetes mellitus and NASH/NAFLD
  • To look for better biomarkers for obesity, insulin resistance and Type-2 diabetes
  • To understand the relationship between inflammation and insulin resistance
  • To further knowledge of the metabolism of iron and insulin resistance
  • To observe the interaction between the Systems Biology and Microbiome / miRNAs / Innate immune system
  • To better understand the association between micriobiome and metabolic diseases
  • To understand the interaction between microbiota and cognitive function
  • To analyse the metabolic image
Publications
Minty M, Germain A, Sun J, Kaglan G, Servant F, Lelouvier B, Misselis E, Neagoe RM, Rossella M, Cardellini M, Burcelin R, Federici M, Fernandez-Real JM, Blasco-Baque V

Identifying the location-dependent adipose tissue bacterial DNA signatures in obese patients that predict body weight loss.

Gut Microbes, 2025, 17, 2439105-2439105 dx.doi.org/10.1080/19490976.2024.2439105
Rubino F, Cummings DE, Eckel RH, Cohen RV, Wilding JPH, Brown WA, Stanford FC, Batterham RL, Farooqi IS, Farpour-Lambert NJ, le Roux CW, Sattar N, Baur LA, Morrison KM, Misra A, Kadowaki T, Tham KW, Sumithran P, Garvey WT, Kirwan JP, Fernández-Real JM, Corkey BE, Toplak H, Kokkinos A, Kushner RF, Branca F, Valabhji J, Blüher M, Bornstein SR, Grill HJ, Ravussin E, Gregg E, Al Busaidi NB, Alfaris NF, Al Ozairi E, Carlsson LMS, Clément K, Després JP, Dixon JB, Galea G, Kaplan LM, Laferrère B, Laville M, Lim S, Luna Fuentes JR, Mooney VM, Nadglowski J Jr, Urudinachi A, Olszanecka-Glinianowicz M, Pan A, Pattou F, Schauer PR, Tschöp MH, van der Merwe MT, Vettor R, Mingrone G

Definition and diagnostic criteria of clinical obesity.

LANCET DIABETES & ENDOCRINOLOGY, 2025, 13, 221-262 dx.doi.org/10.1016/S2213-8587(24)00316-4
Fumagalli, A, Castells-Nobau, A, Trivedi, D, Garre-Olmo, J, Puig, J, Ramos, R, Ramió-Torrentà, L, Pérez-Brocal, V, Moya, A, Swann, J, Martin-Garcia, E, Maldonado, R, Fernández-Real, JM, Mayneris-Perxachs, J

Archaea methanogens are associated with cognitive performance through the shaping of gut microbiota, butyrate and histidine metabolism

Gut Microbes, 2025, 17, 2455506-2455506 dx.doi.org/10.1080/19490976.2025.2455506
Gallardo-Nuell L, Blanch J, Leal Y, Coral DE, Duarte-Salles T, Giordano GN, Franks PW, Pearson ER, Mingrone G, le Roux CW, Ramos R, Fernández-Real JM

BMI-residualized data uncovers a cluster of people with type 2 diabetes and increased serum ferritin protected from cardiovascular disease.

CARDIOVASCULAR DIABETOLOGY, 2025, 24, 139-139 dx.doi.org/10.1186/s12933-025-02685-w
Paulí S, Oliveras-Cañellas N, Moreno-Navarrete JM, Castells-Nobau A, Ortega FJ, Rodriguez-Hermosa JI, Castro E, Zhang B, Zhou Y, Gómez-Ambrosi J, Crujeiras AB, Rangel-Zuñiga OA, Garrido-Sanchez L, Becerril S, Pardo M, Romero-Cabrera JL, Gutierrez-Repiso C, Carreira MC, Macias-Gonzalez M, Martinez-Olmos MÁ, Frühbeck G, Seoane LM, López-Miranda J, Tinahones FJ, Diéguez C, Mayneris-Perxachs J, Fernández-Real JM

Cellular composition and transcriptomics of subcutaneous adipose tissue linked to blood glycated haemoglobin.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2025 dx.doi.org/10.1111/eci.70033
Ruban Agarvas A, Kopf S, Lopes TJS, Atkins JL, Thalmann P, Fernández-Real JM, Nawroth P, Muckenthaler MU

Iron biomarkers predict peripheral artery disease in females.

Atherosclerosis, 2025, 402, 119111-119111 dx.doi.org/10.1016/j.atherosclerosis.2025.119111
Rosell-Díaz M, Fernández-Real JM

Metformin, Cognitive Function, and Changes in the Gut Microbiome

ENDOCRINE REVIEWS, 2024, 45, 210-226 dx.doi.org/10.1210/endrev/bnad029
Moreno-Navarrete JM, Fernández-Real JM

Iron: The silent culprit in your adipose tissue

OBESITY REVIEWS, 2024, 25 dx.doi.org/10.1111/obr.13647
Valenti L, Corradini E, Adams LA, Aigner E, Alqahtani S, Arrese M, Bardou-Jacquet E, Bugianesi E, Fernandez-Real JM, Girelli D, Hagström H, Henninger B, Kowdley K, Ligabue G, McClain D, Lainé F, Miyanishi K, Muckenthaler MU, Pagani A, Pedrotti P, Pietrangelo A, Prati D, Ryan JD, Silvestri L, Spearman CW, Stål P, Tsochatzis EA, Vinchi F, Zheng MH, Zoller H

Consensus Statement on the definition and classification of metabolic hyperferritinaemia (vol 19, pg 299, 2023)

NATURE REVIEWS ENDOCRINOLOGY, 2024, 20, 168-184 dx.doi.org/10.1038/s41574-023-00940-2
Rosell-Díaz M, Santos-González E, Motger-Albertí A, Gallardo-Nuell L, Arnoriaga-Rodríguez M, Coll-Martínez C, Ramió-Torrentà L, Garre-Olmo J, Puig J, Ramos R, Mayneris-Perxachs J, Manuel Fernández-Real J

Lower serum ferritin levels are associated with worse cognitive performance in aging

JOURNAL OF NUTRITION HEALTH & AGING, 2024, 28, 100190-100190 dx.doi.org/10.1016/j.jnha.2024.100190
Competitive projects
Nutrition, Eumetabolism and Health

Stratification of Obese Phenotypes to Optimize Future Obesity Therapy

Codi oficial: 875534 Start date:01/06/2020 Data fi: 28/02/2026 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: EUROPEAN HEALTH AND DIGITAL EXECUTIVE AGENCY (HADEA)
Nutrition, Eumetabolism and Health

Interrelaciones entre las reservas de hierro, el metagenoma intestinal, los niveles de glucosa y diferentes dominios cognitivos: el papel de los microARN circulantes

Codi oficial: PI21/01361 Start date:01/01/2022 Data fi: 30/06/2026 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: INSTITUTO DE SALUD CARLOS III
Nutrition, Eumetabolism and Health

Dianas terapéuticas y biomarcadores de la medicina de precisión en MAFLD.

Codi oficial: PMP21/00072 Start date:01/01/2022 Data fi: 31/12/2025 Investigador/a principal: JORDI MAYNERIS PERXACHS, JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: INSTITUTO DE SALUD CARLOS III
Nutrition, Eumetabolism and Health

Involvement of the gut microbiota-brain cross talk in the loss of eating control

Codi oficial: HR22-00737 Start date:01/10/2022 Data fi: 30/09/2025 Investigador/a principal: ANNA CASTELLS NOBAU, JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: FUNDACIÓN BANCARIA LA CAIXA
Nutrition, Eumetabolism and Health

Ajuts per donar suport a les activitats dels grups de recerca de Catalunya (SGR-Cat 2021) - Nutrició, Eumetabolisme i Salut

Codi oficial: 2021 SGR 01263 Start date:01/01/2022 Data fi: 30/06/2025 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: AGÈNCIA DE GESTIÓ UNIVERSITARIS I RECERCA
Nutrition, Eumetabolism and Health

Ajuda de personal Suport als grups PERIS - Grup de Recerca Nutrició Eumetabolisme i Salut

Codi oficial: SLT028/23/000133 Start date:01/08/2023 Data fi: 31/12/2025 Investigador/a principal: FRANCISCO JOSÉ ORTEGA DELGADO, JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: GENERALITAT DE CATALUNYA
Nutrition, Eumetabolism and Health

Plataforma ISCIII de Biomodelos y Biobancos

Codi oficial: PT23/00089 Start date:01/01/2024 Data fi: 31/12/2026 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: INSTITUTO DE SALUD CARLOS III
Nutrition, Eumetabolism and Health

La expresión génica del tejido adiposo y los vínculos metabolómicos con el eje microbioma intestinal-cerebro (Estudio POINSETTIA)

Codi oficial: PI24/00185 Start date:01/01/2025 Data fi: 31/12/2027 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: INSTITUTO DE SALUD CARLOS III
Nutrition, Eumetabolism and Health

Metabolic crosstalk in ovarian dysfunction: investigating liver-adipose-ovary interactions. Molecular networks and clinical associations.

Codi oficial: 174/C/2024 Start date:20/03/2025 Data fi: 19/03/2028 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: FUNDACIO LA MARATO TV3
Nutrition, Eumetabolism and Health

Candidatura Dr. Fernandez Real Premi Instituto Danone

Codi oficial: 2024_DANONE_JMFR Start date:21/02/2025 Data fi: 31/12/2025 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: INSTITUTO DANONE
Nutrition, Eumetabolism and Health

Candidatura del Dr. Fernández-Real als Premis Fundación Lilly de Investigación Biomédica 2025

Codi oficial: 2025_Lilly_JMFR Start date:31/03/2025 Data fi: 31/12/2025 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: FUNDACIÓN LILLY
Nutrition, Eumetabolism and Health

EFECTOS A LARGO PLAZO DE LA ANULACION ESPECIFICA EN LOS ADIPOCITOS DEL GEN DE LBP EN LA FISIOLOGIA DEL TEJIDO ADIPOSO Y EN LOS TRASTORNOS METABOLICOS ASOCIADOS A OBESIDAD

Codi oficial: PID2022-143113OB-I00 Start date:01/01/2024 Data fi: 31/12/2027 Investigador/a principal: JOSE MARIA MORENO NAVARRETE Organisme finançador: MINISTERIO DE ECONOMIA E INNOVACION
Nutrition, Eumetabolism and Health

AYUDA CONCEDIDA PARA LA FORMACIÓN DE PERSONAL INVESTIGADOR PREDOCTORALCodi oficial: PREP2022-000811

Codi oficial: PREP2022-000811 Start date:01/02/2024 Data fi: 31/01/2028 Investigador/a principal: JOSE MARIA MORENO NAVARRETE Organisme finançador: MINISTERIO DE ECONOMIA E INNOVACION
Nutrition, Eumetabolism and Health

Señalización Auto-paracrina de la gamma-Sinucleína Derivada del Tejido Adiposo en Patología Relacionada con la Obesidad

Codi oficial: PI21/00074 Start date:01/01/2022 Data fi: 30/06/2026 Investigador/a principal: FRANCISCO JOSÉ ORTEGA DELGADO Organisme finançador: INSTITUTO DE SALUD CARLOS III
Nutrition, Eumetabolism and Health

Ayuda de personal Miguel Servet

Codi oficial: CP24/00033 Start date:01/01/2025 Data fi: 31/12/2029 Investigador/a principal: ANNA CASTELLS NOBAU, YAROSLAVA SEMENOVA Organisme finançador: INSTITUTO DE SALUD CARLOS III
Nutrition, Eumetabolism and Health

Premi L'ORÉAL-UNESCO For Women in Science

Codi oficial: L'OREAL_2024_AC Start date:11/06/2025 Data fi: 31/12/2025 Investigador/a principal: ANNA CASTELLS NOBAU Organisme finançador: L'OREAL ESPAÑA
Nutrition, Eumetabolism and Health

Ayuda de proyecto Miguel Servet

Codi oficial: CP24/00033 Start date:01/01/2025 Data fi: 31/12/2028 Investigador/a principal: ANNA CASTELLS NOBAU Organisme finançador: INSTITUTO DE SALUD CARLOS III
Nutrition, Eumetabolism and Health

Ajuda de personal FI - Sara Pauli

Codi oficial: 2023_FI_1 00515 Sara Pauli Start date:01/06/2023 Data fi: 31/05/2026 Investigador/a principal: JORDI MAYNERIS PERXACHS, SARA PAULÍ I PLA Organisme finançador: AGÈNCIA DE GESTIÓ UNIVERSITARIS I RECERCA
Nutrition, Eumetabolism and Health

Conectando obesidad y disfunción de la célula adiposa

Codi oficial: CNS2023-145394 Start date:01/04/2024 Data fi: 30/06/2026 Investigador/a principal: FRANCISCO JOSÉ ORTEGA DELGADO Organisme finançador: MINISTERIO DE ECONOMIA E INNOVACION
Transfer
Patents

Lelouvier Benjamin, Servant Florence, Courtney Michael, Federici Massimo, Fernandez-Real Jose Manuel
METHOD FOR DIAGNOSING HEPATIC FIBROSIS BASED ON BACTERIAL PROFILE AND DIVERSITY
Número de publicació: WO2017060039
Data de publicació: 2018-08-15

Burcelin Rémy, Federici Massimo, Hoyles Lesley, Dumas Marc-Emmanuel, Barton Richard Hadlow, Fernandez-Real José Manuel
METHODS FOR DETERMINING WHETHER A SUBJECT HAS OR IS AT RISK OF HAVING A NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) OR ONE OF ITS COMPLICATIONS
Número de publicació: WO2019077125
Data de publicació: 2019-04-25

Courtney Michael, Lelouvier Benjamin, Federici Massimo, Fernandez-Real Jose Manuel, Païssé Sandrine
METHOD FOR DIAGNOSING HEPATIC FIBROSIS
Número de publicació: WO2015162200
Data de publicació: 2015-10-29

Rafael Maldonado; Aureliju Burokas; Andrés Moya; Vicente Pérez; José Manuel Fernández-Real; Jordi Mayneris; María Arnoriaga.
GUT MICROBIOTA COMPOSITION AND USES THEREOF
Número de publicació: WO2022003059
Data de publicació: 2022-01-06

José Manuel Fernández-Real; José María Moreno Navarrete; Ramón Díaz; Kiyoshi Tachikawa; Priya Kamali; Rajesh Mukthavaram; Padmanabh Chivukula; Aleix Gavaldà; Marta Giralt; Francesc Villarroya.
COMPOSITIONS AND METHODS FOR TREATING METABOLIC DISORDERS
Número de sol·licitud: PCT/US21/65757

Rafael Maldonado; Andrés Moya; Vicente Pérez; José Manuel Fernández-Real; Jordi Mayneris; María Arnoriaga; Anna Castells.
BACTERIÓFAGO PARA USO TERAPÉUTICO
Número de sol·licitud: P202130786

 

Guies clíniques

- “Estrategia en diabetes del Sistema Nacional de Salud- Visión esquemática de la actualización de 2012” Informes, Estudios e Investigación 2014. Ministerios de Sanidad, Servicios Sociales e Igualdad. Wifredo Ricart

Job offers

Team

If you are a researcher and you are interested in collaborating with any of our research groups, please fill in this form.
I am interested in
If you are a student or you want to do an internship with any of our research groups, please fill in this form.
I am interested in

About IDIBGI!

 menu