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The Nutrition, eumetabolism and health research group, led by Professor José Manuel Fernández-Real is made up of 12 doctors (Medicine, Biology and Engineering), 7 pre-graduate researchers, 4 endocrinologists, 3 research technicians, 2 lab technicians, 4 dieticians and 1 nurse.

Main lines of research
  • Innate immune system, inflammation and metabolic diseases
  • Type 2 genomic/genetic diabetes and obesity (including microRNA and long non-coding RNA)
  • Biology of the adipose tissue
  • Iron as a modulator of inflammation to metabolic diseases
  • The role of microbiota in obesity and type 2 diabetes
  • Non-alcoholic steatohepatitis and fatty liver
  • The brain as a metabolic organ
  • Computational tools to optimize glycaemic control
Strategic objectives
  • To study the physiopathology of obesity and comorbidities associated to diabetes mellitus and NASH/NAFLD
  • To look for better biomarkers for obesity, insulin resistance and Type-2 diabetes
  • To understand the relationship between inflammation and insulin resistance
  • To further knowledge of the metabolism of iron and insulin resistance
  • To observe the interaction between the Systems Biology and Microbiome / miRNAs / Innate immune system
  • To better understand the association between micriobiome and metabolic diseases
  • To understand the interaction between microbiota and cognitive function
  • To analyse the metabolic image
Publications

Contreras-Rodriguez O, Arnoriaga-Rodríguez M, Miranda-Olivos R, Blasco G, Biarnés C, Puig J, Rivera-Pinto J, Calle ML, Pérez-Brocal V, Moya A, Coll C, Ramió-Torrentà L, Soriano-Mas C, Fernandez-Real JM

Obesity status and obesity-associated gut dysbiosis effects on hypothalamic structural covariance.

INTERNATIONAL JOURNAL OF OBESITY, 2022, 46, 30-38 dx.doi.org/10.1038/s41366-021-00953-9

Izquierdo AG, Carreira MC, Boughanem H, Navarrete JM, Nicoletti CF, Oliver P, de Luis D, Nonino CB, Portillo MP, Martinez-Olmos MA, Fernandez-Real JM, Tinahones FJ, Martinez JA, Macias-González M, Casanueva FF, Crujeiras AB

Adipose tissue and blood leukocytes ACE2 DNA-methylation in obesity and after weight loss.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2022, 52 dx.doi.org/10.1111/eci.13685

Mayneris-Perxachs J, Castells-Nobau A, Arnoriaga-Rodríguez M, Garre-Olmo J, Puig J, Ramos R, Martínez-Hernández F, Burokas A, Coll C, Moreno-Navarrete JM, Zapata-Tona C, Pedraza S, Pérez-Brocal V, Ramió-Torrentà L, Ricart W, Moya A, Martínez-García M, Maldonado R, Fernández-Real JM

Caudovirales bacteriophages are associated with improved executive function and memory in flies, mice, and humans.

CELL HOST & MICROBE, 2022, 30, 340 dx.doi.org/10.1016/j.chom.2022.01.013

Rodríguez-Barrueco R, Latorre J, Devis-Jáuregui L, Lluch A, Bonifaci N, Llobet FJ, Olivan M, Coll-Iglesias L, Gassner K, Davis ML, Moreno-Navarrete JM, Castells-Nobau A, Plata-Peña L, Dalmau-Pastor M, Höring M, Liebisch G, Olkkonen VM, Arnoriaga-Rodríguez M, Ricart W, Fernández-Real JM, Silva JM, Ortega FJ, Llobet-Navas D

A microRNA Cluster Controls Fat Cell Differentiation and Adipose Tissue Expansion By Regulating SNCG.

Advanced Science, 2022, 9 dx.doi.org/10.1002/advs.202104759

Latorre J, Ortega F, Oliveras-Cañellas N, Comas F, Lluch A, Gavaldà-Navarro A, Morón-Ros S, Ricart W, Villarroya F, Giralt M, Fernández-Real JM, Moreno-Navarrete JM

Specific adipose tissue Lbp gene knockdown prevents diet-induced body weight gain, impacting fat accretion-related gene and protein expression.

MOLECULAR THERAPY-NUCLEIC ACIDS, 2022, 27, 870-879 dx.doi.org/10.1016/j.omtn.2022.01.002

González-García I, Freire-Agulleiro Ó, Nakaya N, Ortega FJ, Garrido-Gil P, Liñares-Pose L, Fernø J, Labandeira-Garcia JL, Diéguez C, Sultana A, Tomarev SI, Fernández-Real JM, López M

Olfactomedin 2 deficiency protects against diet-induced obesity.

METABOLISM-CLINICAL AND EXPERIMENTAL, 2022, 129, 155122-155122 dx.doi.org/10.1016/j.metabol.2021.155122
0

MicroRNAs signatures associated with vulnerability to food addiction in mice and humans.

JOURNAL OF CLINICAL INVESTIGATION, 2022, 132 dx.doi.org/10.1172/JCI156281
0

Bidirectional relationships between the gut microbiome and sexual traits.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2022, 322, 1223-1229 dx.doi.org/10.1152/ajpcell.00116.2022
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Downregulation of peripheral lipopolysaccharide binding protein impacts on perigonadal adipose tissue only in female mice.

BIOMEDICINE & PHARMACOTHERAPY, 2022, 151, 113156-113156 dx.doi.org/10.1016/j.biopha.2022.113156
Competitive projects
Codi oficial: PI18/01022 Start date:01/01/2019 Data fi: 30/06/2023 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 307,642.50 €
Codi oficial: 875534 Start date:09/07/2020 Data fi: 08/07/2025 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: EUROPEAN COMISSION Ajuda: 300,000 €
Codi oficial: AC18/00012 Start date:01/01/2019 Data fi: 30/06/2023 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 149,998.86 €
Codi oficial: FI19/00293 Start date:01/01/2020 Data fi: 31/12/2023 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 82,400 €
Codi oficial: CD20/00051 Start date:01/01/2021 Data fi: 31/12/2023 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 80,598 €
Codi oficial: SMARTAGE Start date:01/09/2020 Data fi: 31/08/2024 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: EUROPEAN COMISSION Ajuda: 417,569.76 €
Codi oficial: 19/0006059 Start date:03/02/2020 Data fi: 02/02/2024 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: DIABETES UK Ajuda: 0 €
Codi oficial: METASUCC Start date:01/12/2020 Data fi: 31/12/2023 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: FUND. BANCARIA "LA CAIXA" Ajuda: 258,752.50 €
Codi oficial: SLT017/20/000164 Start date:12/07/2021 Data fi: 31/12/2024 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: GENERALITAT DE CATALUNYA Ajuda: 92,623.53 €
Codi oficial: PI21/01361 Start date:01/01/2022 Data fi: 31/12/2024 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 304,920 €
Codi oficial: PMP21/00072 Start date:01/01/2022 Data fi: 31/12/2025 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 141,185 €
Codi oficial: PI19/01712 Start date:01/01/2020 Data fi: 31/12/2022 Investigador/a principal: JOSE MARIA MORENO NAVARRETE Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 277,090 €
Codi oficial: PI18/00550 Start date:01/01/2019 Data fi: 31/12/2022 Investigador/a principal: FRANCISCO JOSÉ ORTEGA DELGADO Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 111,320 €
Codi oficial: FI19/00045 Start date:01/01/2020 Data fi: 31/12/2023 Investigador/a principal: FRANCISCO JOSÉ ORTEGA DELGADO Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 82,400 €
Codi oficial: MS19/00109 Start date:01/01/2020 Data fi: 31/12/2024 Investigador/a principal: FRANCISCO JOSÉ ORTEGA DELGADO Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 202,500 €
Codi oficial: PI21/00074 Start date:01/01/2022 Data fi: 31/12/2024 Investigador/a principal: FRANCISCO JOSÉ ORTEGA DELGADO Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 145,200 €
Codi oficial: MS18/00009 Start date:01/01/2019 Data fi: 31/12/2023 Investigador/a principal: JORDI MAYNERIS PERXACHS Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 202,500 €
Codi oficial: PI20/01090 Start date:01/01/2021 Data fi: 31/12/2023 Investigador/a principal: JORDI MAYNERIS PERXACHS Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 171,820 €
Codi oficial: UKRI Cognitive Decline Start date:01/01/2022 Data fi: 31/12/2024 Investigador/a principal: JORDI MAYNERIS PERXACHS Organisme finançador: UK RESEARCH AND INNOVATION (UKRI) Ajuda: 0 €
Transfer
Patents

Lelouvier Benjamin, Servant Florence, Courtney Michael, Federici Massimo, Fernandez-Real Jose Manuel
METHOD FOR DIAGNOSING HEPATIC FIBROSIS BASED ON BACTERIAL PROFILE AND DIVERSITY
Número de publicació: WO2017060039
Data de publicació: 2018-08-15

Burcelin Rémy, Federici Massimo, Hoyles Lesley, Dumas Marc-Emmanuel, Barton Richard Hadlow, Fernandez-Real José Manuel
METHODS FOR DETERMINING WHETHER A SUBJECT HAS OR IS AT RISK OF HAVING A NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) OR ONE OF ITS COMPLICATIONS
Número de publicació: WO2019077125
Data de publicació: 2019-04-25

Courtney Michael, Lelouvier Benjamin, Federici Massimo, Fernandez-Real Jose Manuel, Païssé Sandrine
METHOD FOR DIAGNOSING HEPATIC FIBROSIS
Número de publicació: WO2015162200
Data de publicació: 2015-10-29

Rafael Maldonado; Aureliju Burokas; Andrés Moya; Vicente Pérez; José Manuel Fernández-Real; Jordi Mayneris; María Arnoriaga.
GUT MICROBIOTA COMPOSITION AND USES THEREOF
Número de publicació: WO2022003059
Data de publicació: 2022-01-06

José Manuel Fernández-Real; José María Moreno Navarrete; Ramón Díaz; Kiyoshi Tachikawa; Priya Kamali; Rajesh Mukthavaram; Padmanabh Chivukula; Aleix Gavaldà; Marta Giralt; Francesc Villarroya.
COMPOSITIONS AND METHODS FOR TREATING METABOLIC DISORDERS
Número de sol·licitud: PCT/US21/65757

Rafael Maldonado; Andrés Moya; Vicente Pérez; José Manuel Fernández-Real; Jordi Mayneris; María Arnoriaga; Anna Castells.
BACTERIÓFAGO PARA USO TERAPÉUTICO
Número de sol·licitud: P202130786

 

Guies clíniques

- “Estrategia en diabetes del Sistema Nacional de Salud- Visión esquemática de la actualización de 2012” Informes, Estudios e Investigación 2014. Ministerios de Sanidad, Servicios Sociales e Igualdad. Wifredo Ricart

Job offers
Reference: Beatriu de Pinós (BP) Grants | Nutrition, Eumetabolism and Health
Beatriu de Pinós (BP) Grants Data del termini d'inscripció: 20230224

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