Nutrition, Eumetabolism and Health

The Nutrition, eumetabolism and health research group, led by Professor José Manuel Fernández-Real is made up of 12 doctors (Medicine, Biology and Engineering), 7 pre-graduate researchers, 4 endocrinologists, 3 research technicians, 2 lab technicians, 4 dieticians and 1 nurse.

Main lines of research

Innate immune system, inflammation and metabolic diseases
Type 2 genomic/genetic diabetes and obesity (including microRNA and long non-coding RNA)
Biology of the adipose tissue
Iron as a modulator of inflammation to metabolic diseases
The role of microbiota in obesity and type 2 diabetes
Non-alcoholic steatohepatitis and fatty liver
The brain as a metabolic organ
Computational tools to optimize glycaemic control

Strategic objectives

To study the physiopathology of obesity and comorbidities associated to diabetes mellitus and NASH/NAFLD
To look for better biomarkers for obesity, insulin resistance and Type-2 diabetes
To understand the relationship between inflammation and insulin resistance
To further knowledge of the metabolism of iron and insulin resistance
To observe the interaction between the Systems Biology and Microbiome / miRNAs / Innate immune system
To better understand the association between micriobiome and metabolic diseases
To understand the interaction between microbiota and cognitive function
To analyse the metabolic image

Publications

Nutrition, Eumetabolism and Health

Bishop E, Allington D, Ringrose T, Martin C, Aldea A, García-Jaramillo M, León-Vargas F, Leal Y, Henao D, Gómez AM

Design and Usability of an Avatar-Based Learning Program to Support Diabetes Education: Quality Improvement Study in Colombia.

Journal Of Diabetes Science And Technology, 2023, 17, 1142-1153 dx.doi.org/10.1177/19322968221136141

Nutrition, Eumetabolism and Health

Milbank E, Díaz-Trelles R, Dragano N, Latorre J, Mukthavaram R, Mayneris-Perxachs J, Ortega F, Federici M, Burcelin R, Karmali PP, Tachikawa K, Chivukula P, López M, Fernández-Real JM, Moreno-Navarrete JM

Liver lipopolysaccharide binding protein prevents hepatic inflammation in physiological and pathological non-obesogenic conditions

PHARMACOLOGICAL RESEARCH, 2023, 187, 106562-106562 dx.doi.org/10.1016/j.phrs.2022.106562

Nutrition, Eumetabolism and Health

Paton B, Foguet-Romero E, Suarez M, Mayneris-Perxachs J, Boqué N, Caimari A, Canela N, Herrero P

Brain N-Glycosylation and Lipidomic Profile Changes Induced by a High-Fat Diet in Dyslipidemic Hamsters.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 dx.doi.org/10.3390/ijms24032883

Nutrition, Eumetabolism and Health

Champion C, Neagoe RM, Effernberger M, Sala DT, Servant F, Christensen JE, Arnoriaga-Rodriguez M, Amar J, Lelouvier B, Loubieres P, Azalbert V, Minty M, Thomas C, Blasco-Baque V, Gamboa F, Tilg H, Cardellini M, Federici M, Fernández-Real JM, Loubes JM, Burcelin R

Human liver microbiota modeling strategy at the early onset of fibrosis.

BMC MICROBIOLOGY, 2023, 23, 34-34 dx.doi.org/10.1186/s12866-023-02774-4

Medical Imaging , Nutrition, Eumetabolism and Health

Hinojosa-Moscoso A, Motger-Albertí A, De la Calle-Vargas E, Martí-Navas M, Biarnés C, Arnoriaga-Rodríguez M, Blasco G, Puig J, Luque-Córdoba D, Priego-Capote F, Moreno-Navarrete JM, Fernández-Real JM

The Longitudinal Changes in Subcutaneous Abdominal Tissue and Visceral Adipose Tissue Volumetries Are Associated with Iron Status.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 dx.doi.org/10.3390/ijms24054750

Nutrition, Eumetabolism and Health

González-Moro I, Rojas-Márquez H, Sebastian-delaCruz M, Mentxaka-Salgado J, Olazagoitia-Garmendia A, Mendoza LM, Lluch A, Fantuzzi F, Lambert C, Ares Blanco J, Marselli L, Marchetti P, Cnop M, Delgado E, Fernández-Real JM, Ortega FJ, Castellanos-Rubio A, Santin I

A long non-coding RNA that harbors a SNP associated with type 2 diabetes regulates the expression of TGM2 gene in pancreatic beta cells.

Frontiers in Endocrinology, 2023, 14, 1101934-1101934 dx.doi.org/10.3389/fendo.2023.1101934

Nutrition, Eumetabolism and Health

Valenti L, Corradini E, Adams LA, Aigner E, Alqahtani S, Arrese M, Bardou-Jacquet E, Bugianesi E, Fernandez-Real JM, Girelli D, Hagström H, Henninger B, Kowdley K, Ligabue G, McClain D, Lainé F, Miyanishi K, Muckenthaler MU, Pagani A, Pedrotti P, Pietrangelo A, Prati D, Ryan JD, Silvestri L, Spearman CW, Stål P, Tsochatzis EA, Vinchi F, Zheng MH, Zoller H

Consensus Statement on the definition and classification of metabolic hyperferritinaemia.

NATURE REVIEWS ENDOCRINOLOGY, 2023, 19, 1-12 dx.doi.org/10.1038/s41574-023-00807-6

Nutrition, Eumetabolism and Health , Research in Vascular Health

Serrat-Costa M, Coll de Tuero G, Bertran Noguer C, Martí Lluch R, Ramos Blanes R, Baltasar Bagué A, Ricart W

Arterial hypertension diagnosis: A problem?

Hipertension y Riesgo Vascular, 2023, 40, 58-64 dx.doi.org/10.1016/j.hipert.2022.09.003

Medical Imaging , Cerebrovascular Pathology , Private: Aging, Disability and Health , Neurodegeneration and Neuroinflammation , Nutrition, Eumetabolism and Health , Cardiovascular Genetics , Research in Vascular Health

Sol J, Obis È, Mota-Martorell N, Pradas I, Galo-Licona JD, Martin-Garí M, Fernández-Bernal A, Ortega-Bravo M, Mayneris-Perxachs J, Borrás C, Viña J, de la Fuente M, Mate I, Biarnes C, Pedraza S, Vilanova JC, Brugada R, Ramos R, Serena J, Ramió-Torrentà L, Pineda V, Daunis-I-Estadella P, Thió-Henestrosa S, Barretina J, Garre-Olmo J, Portero-Otin M, Fernández-Real JM, Puig J, Jové M, Pamplona R

Plasma acylcarnitines and gut-derived aromatic amino acids as sex-specific hub metabolites of the human aging metabolome.

Aging Cell, 2023, 22 dx.doi.org/10.1111/acel.13821

Nutrition, Eumetabolism and Health

Mayneris-Perxachs J, Fernández-Real JM

Proline-related metabolites: Towards biological diagnosis of depression.

PSYCHIATRY AND CLINICAL NEUROSCIENCES, 2023, 77, 195-195 dx.doi.org/10.1111/pcn.13535

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Competitive projects

Nutrition, Eumetabolism and Health

Stratification of Obese Phenotypes to Optimize Future Obesity Therapy

Codi oficial: SOPHIA Start date:09/07/2020 Data fi: 08/07/2025 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: EUROPEAN COMISSION Ajuda: 300,000 €

Nutrition, Eumetabolism and Health

Ayuda de personal PFIS

Codi oficial: FI19/00293 Start date:01/01/2020 Data fi: 31/12/2023 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 82,400 €

Nutrition, Eumetabolism and Health

Ayuda de personal Sara Borrell

Codi oficial: CD20/00051 Start date:01/01/2021 Data fi: 17/06/2024 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 80,598 €

Nutrition, Eumetabolism and Health

Gut-brain-axis: Targets for improvement of cognition in the elderly

Codi oficial: SMARTAGE Start date:01/09/2020 Data fi: 31/08/2024 Investigador/a principal: JORDI MAYNERIS PERXACHS, JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: EUROPEAN COMISSION Ajuda: 417,569.76 €

Nutrition, Eumetabolism and Health

Evaluating Microbiome Causality in the Gut-Liver Axis and Impact on Insulin Resistance

Codi oficial: 19/0006059 Start date:03/02/2020 Data fi: 02/02/2024 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: DIABETES UK Ajuda: 0 €

Nutrition, Eumetabolism and Health

SUCCINATE/SUCNR1 AXIS: A NOVEL TARGET FOR ANTI-OBESITY THERAPIES

Codi oficial: METASUCC Start date:01/12/2020 Data fi: 31/12/2024 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: FUND. BANCARIA "LA CAIXA" Ajuda: 258,752.50 €

Nutrition, Eumetabolism and Health

Ajuda de personal PERIS Lisset de la Vega

Codi oficial: SLT017/20/000164 Start date:12/07/2021 Data fi: 31/12/2024 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: GENERALITAT DE CATALUNYA Ajuda: 92,623.53 €

Nutrition, Eumetabolism and Health

Interrelaciones entre las reservas de hierro, el metagenoma intestinal, los niveles de glucosa y diferentes dominios cognitivos: el papel de los microARN circulantes

Codi oficial: PI21/01361 Start date:01/01/2022 Data fi: 31/12/2024 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 304,920 €

Nutrition, Eumetabolism and Health

Dianas terapéuticas y biomarcadores de la medicina de precisión en MAFLD.

Codi oficial: PMP21/00072 Start date:01/01/2022 Data fi: 31/12/2025 Investigador/a principal: JORDI MAYNERIS PERXACHS, JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 141,185 €

Nutrition, Eumetabolism and Health

Involvement of the gut microbiota-brain cross talk in the loss of eating control

Codi oficial: HR22-00737 Start date:01/10/2022 Data fi: 30/09/2025 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: FUND. BANCARIA "LA CAIXA" Ajuda: 374,894.76 €

Nutrition, Eumetabolism and Health

Ayuda de personal Intensificación 2022

Codi oficial: INT22/00015 Start date:01/01/2023 Data fi: 31/12/2024 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 60,000 €

Nutrition, Eumetabolism and Health

Ajuts per donar suport a les activitats dels grups de recerca de Catalunya (SGR-Cat 2021) - Nutrició, Eumetabolisme i Salut

Codi oficial: 2021 SGR 01263 Start date:01/01/2022 Data fi: 31/12/2024 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: AGENCIA DE GESTIO D'AJUTS UNIV. I RECER. Ajuda: 60,000 €

Nutrition, Eumetabolism and Health

Nuevos retos en investigación sobre plasticidad adiposa (ADIPOBROAD)

Codi oficial: RED2022-134313-T Start date:01/06/2023 Data fi: 31/05/2025 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: MINISTERIO DE ECONOMIA Y COMPETITIVIDAD MINECO / Ajuda: 0 €

Nutrition, Eumetabolism and Health

Ajuda de personal Suport als grups PERIS - Grup de Recerca Nutrició Eumetabolisme i Salut

Codi oficial: SLT028/23/000133 Start date:01/08/2023 Data fi: 31/12/2025 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: GENERALITAT DE CATALUNYA Ajuda: 75,784.93 €

Nutrition, Eumetabolism and Health

Are there any link between microbial products accumulation in adipose tissue and obesity associated insulin resistance? The possible role of LBP and lysozyme.

Codi oficial: PI19/01712 Start date:01/01/2020 Data fi: 30/06/2024 Investigador/a principal: JOSE MARIA MORENO NAVARRETE Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 277,090 €

Nutrition, Eumetabolism and Health

Ayuda de personal Miquel Servet

Codi oficial: MS19/00109 Start date:01/01/2020 Data fi: 31/12/2024 Investigador/a principal: FRANCISCO JOSÉ ORTEGA DELGADO Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 202,500 €

Nutrition, Eumetabolism and Health

Señalización Auto-paracrina de la gamma-Sinucleína Derivada del Tejido Adiposo en Patología Relacionada con la Obesidad

Codi oficial: PI21/00074 Start date:01/01/2022 Data fi: 31/12/2024 Investigador/a principal: FRANCISCO JOSÉ ORTEGA DELGADO Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 145,200 €

Nutrition, Eumetabolism and Health

Ayuda de personal Miquel Servet. Systems biology approach to unravel the pathogenesis of non-alcoholic fatty liver disease (NAFLD)

Codi oficial: MS18/00009 Start date:01/01/2019 Data fi: 24/03/2024 Investigador/a principal: JORDI MAYNERIS PERXACHS Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 202,500 €

Nutrition, Eumetabolism and Health

Tryptophan Metabolism: A link between the gut microbiome and cognitive function in obesity and related low-grade chronic inflammation disorders

Codi oficial: PI20/01090 Start date:01/01/2021 Data fi: 31/12/2024 Investigador/a principal: JORDI MAYNERIS PERXACHS Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 171,820 €

Nutrition, Eumetabolism and Health

Investigating the influence of gut microbial metabolism on normal age-related cognitive decline. WP4: Multi-omics analyses and integration.

Codi oficial: UKRI Cognitive Decline Start date:01/01/2022 Data fi: 31/12/2024 Investigador/a principal: JORDI MAYNERIS PERXACHS Organisme finançador: UK RESEARCH AND INNOVATION (UKRI) Ajuda: 0 €

Nutrition, Eumetabolism and Health

Ajuda de personal FI - Sara Pauli

Codi oficial: 2023_FI_1 00515 Sara Pauli Start date:01/06/2023 Data fi: 31/05/2026 Investigador/a principal: JORDI MAYNERIS PERXACHS, SARA PAULÍ I PLA Organisme finançador: AGENCIA DE GESTIO D'AJUTS UNIV. I RECER. Ajuda: 71,492.72 €

Transfer

Patents

Lelouvier Benjamin, Servant Florence, Courtney Michael, Federici Massimo, Fernandez-Real Jose Manuel
METHOD FOR DIAGNOSING HEPATIC FIBROSIS BASED ON BACTERIAL PROFILE AND DIVERSITY
Número de publicació: WO2017060039
Data de publicació: 2018-08-15

Burcelin Rémy, Federici Massimo, Hoyles Lesley, Dumas Marc-Emmanuel, Barton Richard Hadlow, Fernandez-Real José Manuel
METHODS FOR DETERMINING WHETHER A SUBJECT HAS OR IS AT RISK OF HAVING A NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) OR ONE OF ITS COMPLICATIONS
Número de publicació: WO2019077125
Data de publicació: 2019-04-25

Courtney Michael, Lelouvier Benjamin, Federici Massimo, Fernandez-Real Jose Manuel, Païssé Sandrine
METHOD FOR DIAGNOSING HEPATIC FIBROSIS
Número de publicació: WO2015162200
Data de publicació: 2015-10-29

Rafael Maldonado; Aureliju Burokas; Andrés Moya; Vicente Pérez; José Manuel Fernández-Real; Jordi Mayneris; María Arnoriaga.
GUT MICROBIOTA COMPOSITION AND USES THEREOF
Número de publicació: WO2022003059
Data de publicació: 2022-01-06

José Manuel Fernández-Real; José María Moreno Navarrete; Ramón Díaz; Kiyoshi Tachikawa; Priya Kamali; Rajesh Mukthavaram; Padmanabh Chivukula; Aleix Gavaldà; Marta Giralt; Francesc Villarroya.
COMPOSITIONS AND METHODS FOR TREATING METABOLIC DISORDERS
Número de sol·licitud: PCT/US21/65757

Rafael Maldonado; Andrés Moya; Vicente Pérez; José Manuel Fernández-Real; Jordi Mayneris; María Arnoriaga; Anna Castells.
BACTERIÓFAGO PARA USO TERAPÉUTICO
Número de sol·licitud: P202130786

Guies clíniques

- “Estrategia en diabetes del Sistema Nacional de Salud- Visión esquemática de la actualización de 2012” Informes, Estudios e Investigación 2014. Ministerios de Sanidad, Servicios Sociales e Igualdad. Wifredo Ricart

Job offers

Design and Usability of an Avatar-Based Learning Program to Support Diabetes Education: Quality Improvement Study in Colombia.

Liver lipopolysaccharide binding protein prevents hepatic inflammation in physiological and pathological non-obesogenic conditions

Brain N-Glycosylation and Lipidomic Profile Changes Induced by a High-Fat Diet in Dyslipidemic Hamsters.

Human liver microbiota modeling strategy at the early onset of fibrosis.

The Longitudinal Changes in Subcutaneous Abdominal Tissue and Visceral Adipose Tissue Volumetries Are Associated with Iron Status.

A long non-coding RNA that harbors a SNP associated with type 2 diabetes regulates the expression of TGM2 gene in pancreatic beta cells.

Consensus Statement on the definition and classification of metabolic hyperferritinaemia.

Arterial hypertension diagnosis: A problem?

Plasma acylcarnitines and gut-derived aromatic amino acids as sex-specific hub metabolites of the human aging metabolome.

Proline-related metabolites: Towards biological diagnosis of depression.

Patents

Guies clíniques

Team

Group leader - R4

Established researchers - R3

Postdoctorals researchers – R2

Predoctorals researchers – R1

Research technicians

Emeritus researcher

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