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The Nutrition, eumetabolism and health research group, led by Professor José Manuel Fernández-Real is made up of 12 doctors (Medicine, Biology and Engineering), 7 pre-graduate researchers, 4 endocrinologists, 3 research technicians, 2 lab technicians, 4 dieticians and 1 nurse.

Main lines of research
  • Innate immune system, inflammation and metabolic diseases
  • Type 2 genomic/genetic diabetes and obesity (including microRNA and long non-coding RNA)
  • Biology of the adipose tissue
  • Iron as a modulator of inflammation to metabolic diseases
  • The role of microbiota in obesity and type 2 diabetes
  • Non-alcoholic steatohepatitis and fatty liver
  • The brain as a metabolic organ
  • Computational tools to optimize glycaemic control
Strategic objectives
  • To study the physiopathology of obesity and comorbidities associated to diabetes mellitus and NASH/NAFLD
  • To look for better biomarkers for obesity, insulin resistance and Type-2 diabetes
  • To understand the relationship between inflammation and insulin resistance
  • To further knowledge of the metabolism of iron and insulin resistance
  • To observe the interaction between the Systems Biology and Microbiome / miRNAs / Innate immune system
  • To better understand the association between micriobiome and metabolic diseases
  • To understand the interaction between microbiota and cognitive function
  • To analyse the metabolic image
Publications
Moreno-Navarrete JM, Fernández-Real JM

Iron: The silent culprit in your adipose tissue.

OBESITY REVIEWS, 2024, 25 dx.doi.org/10.1111/obr.13647
Motger-Albertí A, de la Calle E, Giménez M, Blasco G, Biarnés C, Arnoriaga-Rodríguez M, Puig J, Coll-Martínez C, Contreras-Rodríguez O, Fernández-Real JM

Increased brain fractional perfusion in obesity using intravoxel incoherent motion (IVIM) MRI metrics.

Obesity, 2024, 32, 756-767 dx.doi.org/10.1002/oby.24001
Mayneris-Perxachs J, Castells-Nobau A, Fernández-Real JM

"Indole-gence" for the mind.

CELL HOST & MICROBE, 2024, 32, 151-153 dx.doi.org/10.1016/j.chom.2024.01.006
Delfin C, Dragan I, Kuznetsov D, Tajes JF, Smit F, Coral DE, Farzaneh A, Haugg A, Hungele A, Niknejad A, Hall C, Jacobs D, Marek D, Fraser DP, Thuillier D, Ahmadizar F, Mehl F, Pattou F, Burdet F, Hawkes G, Arts ICW, Blanch J, Van Soest J, Fernández-Real JM, Boehl J, Fink K, van Greevenbroek MMJ, Kavousi M, Minten M, Prinz N, Ipsen N, Franks PW, Ramos R, Holl RW, Horban S, Duarte-Salles T, Tran VDT, Raverdy V, Leal Y, Lenart A, Pearson E, Sparsø T, Giordano GN, Ioannidis V, Soh K, Frayling TM, Le Roux CW, Ibberson M

A Federated Database for Obesity Research: An IMI-SOPHIA Study.

LIFE-BASEL, 2024, 14 dx.doi.org/10.3390/life14020262
Bishop E, Allington D, Ringrose T, Martin C, Aldea A, García-Jaramillo M, León-Vargas F, Leal Y, Henao D, Gómez AM

Design and Usability of an Avatar-Based Learning Program to Support Diabetes Education: Quality Improvement Study in Colombia.

Journal Of Diabetes Science And Technology, 2023, 17, 1142-1153 dx.doi.org/10.1177/19322968221136141
Milbank E, Díaz-Trelles R, Dragano N, Latorre J, Mukthavaram R, Mayneris-Perxachs J, Ortega F, Federici M, Burcelin R, Karmali PP, Tachikawa K, Chivukula P, López M, Fernández-Real JM, Moreno-Navarrete JM

Liver lipopolysaccharide binding protein prevents hepatic inflammation in physiological and pathological non-obesogenic conditions

PHARMACOLOGICAL RESEARCH, 2023, 187, 106562-106562 dx.doi.org/10.1016/j.phrs.2022.106562
Paton B, Foguet-Romero E, Suarez M, Mayneris-Perxachs J, Boqué N, Caimari A, Canela N, Herrero P

Brain N-Glycosylation and Lipidomic Profile Changes Induced by a High-Fat Diet in Dyslipidemic Hamsters.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 dx.doi.org/10.3390/ijms24032883
Champion C, Neagoe RM, Effernberger M, Sala DT, Servant F, Christensen JE, Arnoriaga-Rodriguez M, Amar J, Lelouvier B, Loubieres P, Azalbert V, Minty M, Thomas C, Blasco-Baque V, Gamboa F, Tilg H, Cardellini M, Federici M, Fernández-Real JM, Loubes JM, Burcelin R

Human liver microbiota modeling strategy at the early onset of fibrosis.

BMC MICROBIOLOGY, 2023, 23, 34-34 dx.doi.org/10.1186/s12866-023-02774-4
Hinojosa-Moscoso A, Motger-Albertí A, De la Calle-Vargas E, Martí-Navas M, Biarnés C, Arnoriaga-Rodríguez M, Blasco G, Puig J, Luque-Córdoba D, Priego-Capote F, Moreno-Navarrete JM, Fernández-Real JM

The Longitudinal Changes in Subcutaneous Abdominal Tissue and Visceral Adipose Tissue Volumetries Are Associated with Iron Status.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 dx.doi.org/10.3390/ijms24054750
González-Moro I, Rojas-Márquez H, Sebastian-delaCruz M, Mentxaka-Salgado J, Olazagoitia-Garmendia A, Mendoza LM, Lluch A, Fantuzzi F, Lambert C, Ares Blanco J, Marselli L, Marchetti P, Cnop M, Delgado E, Fernández-Real JM, Ortega FJ, Castellanos-Rubio A, Santin I

A long non-coding RNA that harbors a SNP associated with type 2 diabetes regulates the expression of TGM2 gene in pancreatic beta cells.

Frontiers in Endocrinology, 2023, 14, 1101934-1101934 dx.doi.org/10.3389/fendo.2023.1101934
Competitive projects
Nutrition, Eumetabolism and Health

Stratification of Obese Phenotypes to Optimize Future Obesity Therapy

Codi oficial: SOPHIA Start date:09/07/2020 Data fi: 08/07/2025 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: EUROPEAN COMISSION
Nutrition, Eumetabolism and Health

Ayuda de personal Sara Borrell

Codi oficial: CD20/00051 Start date:01/01/2021 Data fi: 17/06/2024 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: INSTITUTO DE SALUD CARLOS III
Nutrition, Eumetabolism and Health

Gut-brain-axis: Targets for improvement of cognition in the elderly

Codi oficial: SMARTAGE Start date:01/09/2020 Data fi: 31/08/2024 Investigador/a principal: JORDI MAYNERIS PERXACHS, JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: EUROPEAN COMISSION
Nutrition, Eumetabolism and Health

Ajuda de personal PERIS Lisset de la Vega

Codi oficial: SLT017/20/000164 Start date:12/07/2021 Data fi: 31/12/2024 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: GENERALITAT DE CATALUNYA
Nutrition, Eumetabolism and Health

Interrelaciones entre las reservas de hierro, el metagenoma intestinal, los niveles de glucosa y diferentes dominios cognitivos: el papel de los microARN circulantes

Codi oficial: PI21/01361 Start date:01/01/2022 Data fi: 31/12/2024 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: INSTITUTO DE SALUD CARLOS III
Nutrition, Eumetabolism and Health

Dianas terapéuticas y biomarcadores de la medicina de precisión en MAFLD.

Codi oficial: PMP21/00072 Start date:01/01/2022 Data fi: 31/12/2025 Investigador/a principal: JORDI MAYNERIS PERXACHS, JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: INSTITUTO DE SALUD CARLOS III
Nutrition, Eumetabolism and Health

Involvement of the gut microbiota-brain cross talk in the loss of eating control

Codi oficial: HR22-00737 Start date:01/10/2022 Data fi: 30/09/2025 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: FUND. BANCARIA "LA CAIXA"
Nutrition, Eumetabolism and Health

Ayuda de personal Intensificación 2022

Codi oficial: INT22/00015 Start date:01/01/2023 Data fi: 31/12/2024 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: INSTITUTO DE SALUD CARLOS III
Nutrition, Eumetabolism and Health

Ajuts per donar suport a les activitats dels grups de recerca de Catalunya (SGR-Cat 2021) - Nutrició, Eumetabolisme i Salut

Codi oficial: 2021 SGR 01263 Start date:01/01/2022 Data fi: 30/06/2025 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: AGENCIA DE GESTIO D'AJUTS UNIV. I RECER.
Nutrition, Eumetabolism and Health

Nuevos retos en investigación sobre plasticidad adiposa (ADIPOBROAD)

Codi oficial: RED2022-134313-T Start date:01/06/2023 Data fi: 31/05/2025 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: MINISTERIO DE ECONOMIA Y COMPETITIVIDAD MINECO /
Nutrition, Eumetabolism and Health

Ajuda de personal Suport als grups PERIS - Grup de Recerca Nutrició Eumetabolisme i Salut

Codi oficial: SLT028/23/000133 Start date:01/08/2023 Data fi: 31/12/2025 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: GENERALITAT DE CATALUNYA
Nutrition, Eumetabolism and Health

Plataforma ISCIII de Biomodelos y Biobancos

Codi oficial: PT23/00089 Start date:01/01/2024 Data fi: 31/12/2026 Investigador/a principal: JOSÉ MANUEL FERNÁNDEZ-REAL LEMOS Organisme finançador: INSTITUTO DE SALUD CARLOS III
Nutrition, Eumetabolism and Health

Are there any link between microbial products accumulation in adipose tissue and obesity associated insulin resistance? The possible role of LBP and lysozyme.

Codi oficial: PI19/01712 Start date:01/01/2020 Data fi: 30/06/2024 Investigador/a principal: JOSE MARIA MORENO NAVARRETE Organisme finançador: INSTITUTO DE SALUD CARLOS III
Nutrition, Eumetabolism and Health

Ayuda de personal Miquel Servet

Codi oficial: MS19/00109 Start date:01/01/2020 Data fi: 31/12/2024 Investigador/a principal: FRANCISCO JOSÉ ORTEGA DELGADO Organisme finançador: INSTITUTO DE SALUD CARLOS III
Nutrition, Eumetabolism and Health

Señalización Auto-paracrina de la gamma-Sinucleína Derivada del Tejido Adiposo en Patología Relacionada con la Obesidad

Codi oficial: PI21/00074 Start date:01/01/2022 Data fi: 31/12/2024 Investigador/a principal: FRANCISCO JOSÉ ORTEGA DELGADO Organisme finançador: INSTITUTO DE SALUD CARLOS III
Nutrition, Eumetabolism and Health

Conectando obesidad y disfunción de la célula adiposa

Codi oficial: CNS2023-145394 Start date:01/04/2024 Data fi: 31/03/2026 Investigador/a principal: FRANCISCO JOSÉ ORTEGA DELGADO Organisme finançador: MINISTERIO DE ECONOMIA Y COMPETITIVIDAD MINECO /
Nutrition, Eumetabolism and Health

Tryptophan Metabolism: A link between the gut microbiome and cognitive function in obesity and related low-grade chronic inflammation disorders

Codi oficial: PI20/01090 Start date:01/01/2021 Data fi: 31/12/2024 Investigador/a principal: JORDI MAYNERIS PERXACHS Organisme finançador: INSTITUTO DE SALUD CARLOS III
Nutrition, Eumetabolism and Health

Investigating the influence of gut microbial metabolism on normal age-related cognitive decline. WP4: Multi-omics analyses and integration.

Codi oficial: UKRI Cognitive Decline Start date:01/01/2022 Data fi: 31/12/2024 Investigador/a principal: JORDI MAYNERIS PERXACHS Organisme finançador: UK RESEARCH AND INNOVATION (UKRI)
Nutrition, Eumetabolism and Health

Ajuda de personal FI - Sara Pauli

Codi oficial: 2023_FI_1 00515 Sara Pauli Start date:01/06/2023 Data fi: 31/05/2026 Investigador/a principal: JORDI MAYNERIS PERXACHS, SARA PAULÍ I PLA Organisme finançador: AGENCIA DE GESTIO D'AJUTS UNIV. I RECER.
Nutrition, Eumetabolism and Health

Papel del eje Microbioma-Intestino-Cerebro en la relación bidireccional entre obesidad y depresión: metabolitos y miRNAs como mediadores.

Codi oficial: PI23/00575 Start date:01/01/2024 Data fi: 31/12/2026 Investigador/a principal: JORDI MAYNERIS PERXACHS Organisme finançador: INSTITUTO DE SALUD CARLOS III
Nutrition, Eumetabolism and Health

Papel del microbioma intestinal en la relación obesidad-depresión: miRNAs y metabolitos como mediadores (GUTMOOD)

Codi oficial: CNS2023-144218 Start date:01/04/2024 Data fi: 31/03/2026 Investigador/a principal: JORDI MAYNERIS PERXACHS Organisme finançador: MINISTERIO DE ECONOMIA Y COMPETITIVIDAD MINECO /
Nutrition, Eumetabolism and Health

Desarrollo de modelos personalizados para el estudio del eje microbiota-intestino-cerebro en la progresión de trastornos cognitivos asociados a la enfermedad de Alzheimer

Codi oficial: 2023_IBEC_JMP Start date:01/03/2024 Data fi: 30/06/2025 Investigador/a principal: JORDI MAYNERIS PERXACHS Organisme finançador: FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
Transfer
Patents

Lelouvier Benjamin, Servant Florence, Courtney Michael, Federici Massimo, Fernandez-Real Jose Manuel
METHOD FOR DIAGNOSING HEPATIC FIBROSIS BASED ON BACTERIAL PROFILE AND DIVERSITY
Número de publicació: WO2017060039
Data de publicació: 2018-08-15

Burcelin Rémy, Federici Massimo, Hoyles Lesley, Dumas Marc-Emmanuel, Barton Richard Hadlow, Fernandez-Real José Manuel
METHODS FOR DETERMINING WHETHER A SUBJECT HAS OR IS AT RISK OF HAVING A NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) OR ONE OF ITS COMPLICATIONS
Número de publicació: WO2019077125
Data de publicació: 2019-04-25

Courtney Michael, Lelouvier Benjamin, Federici Massimo, Fernandez-Real Jose Manuel, Païssé Sandrine
METHOD FOR DIAGNOSING HEPATIC FIBROSIS
Número de publicació: WO2015162200
Data de publicació: 2015-10-29

Rafael Maldonado; Aureliju Burokas; Andrés Moya; Vicente Pérez; José Manuel Fernández-Real; Jordi Mayneris; María Arnoriaga.
GUT MICROBIOTA COMPOSITION AND USES THEREOF
Número de publicació: WO2022003059
Data de publicació: 2022-01-06

José Manuel Fernández-Real; José María Moreno Navarrete; Ramón Díaz; Kiyoshi Tachikawa; Priya Kamali; Rajesh Mukthavaram; Padmanabh Chivukula; Aleix Gavaldà; Marta Giralt; Francesc Villarroya.
COMPOSITIONS AND METHODS FOR TREATING METABOLIC DISORDERS
Número de sol·licitud: PCT/US21/65757

Rafael Maldonado; Andrés Moya; Vicente Pérez; José Manuel Fernández-Real; Jordi Mayneris; María Arnoriaga; Anna Castells.
BACTERIÓFAGO PARA USO TERAPÉUTICO
Número de sol·licitud: P202130786

 

Guies clíniques

- “Estrategia en diabetes del Sistema Nacional de Salud- Visión esquemática de la actualización de 2012” Informes, Estudios e Investigación 2014. Ministerios de Sanidad, Servicios Sociales e Igualdad. Wifredo Ricart

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