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The Metabolism and Cancer group adopts the view that cancer diseases are governed by metabolic reprogramming. Our laboratory pursues to understand the contribution of dysregulated metabolism in cancer initiation, drug resistance, and metastatic progression using laboratory-based experimental and computational tools through completion of clinical proof-of-efficacy in cancer patients.

Main lines of research
  1. Metabolism and cancer
  • Mechanistic understanding of metabolism-driven tumorigenesis
  • Metabolic mechanisms of cancer drug resistance
  • Identification of metabolic vulnerabilities as pharmacological targets for cancer therapy
  • Metabolomics and metabolic markers for early detection and clinical monitoring of cancer initiation, progression, and therapeutic resistance
  • Metabolo-epigenetics: Molecular aspects, computational modeling, and therapeutic development of precision medicine approaches

 

  1. Mitochondrial dynamics and cancer
  • Role of autophagy and mitochondria fussion/fission in the generation of cancer stem cells
  • Mitochondrial dynamics-targeted therapeutics for cancer therapy

 

  1. Natural biocompounds and cancer
  • Discovery and molecular characterization of natural biocompounds with anti-cancer properties
  • Pre-clinical development and clinical evaluation of natural biocompounds-based anti-cancer drugs

 

  1. Metabolo-immunotherapy
  • Identification of metabolic nodes and small-molecule metabolites essential for the regulation of immune checkpoints in cancer cells
  • Metabolic and dietary interventions to boost the efficacy of immune checkpoint inhibitors (ICIs).
  • Computational development and pre-clinical validation of in silico clinical trials platforms for testing new metabolo-immunotherapy approaches

 

  1. Computational systems biology in aging-driven cancer
  • Conceptual frameworks, stochastic tools, and wet-lab validation of metabolic and metabolo-epigenetic models of aging-driven cancer
Strategic objectives

To advance new metabolism-based anti-cancer therapeutics.

Publications
Jiménez-Franco A, Castañé H, Martínez-Navidad C, Placed-Gallego C, Hernández-Aguilera A, Fernández-Arroyo S, Samarra I, Canela-Capdevila M, Arenas M, Zorzano A, Hernández-Alvarez MI, Castillo DD, Paris M, Menendez JA, Camps J, Joven J

Metabolic adaptations in severe obesity: Insights from circulating oxylipins before and after weight loss

CLINICAL NUTRITION, 2024, 43, 246-258 dx.doi.org/10.1016/j.clnu.2023.12.002
Menendez JA, Cuyàs E, Encinar JA, Steen TV, Verdura S, Llop-Hernández À, López J, Serrano-Hervás E, Osuna S, Martin-Castillo B, Lupu R

Fatty acid synthase (FASN) signalome: A molecular guide for precision oncology

MOLECULAR ONCOLOGY, 2024, 18, 479-516 dx.doi.org/10.1002/1878-0261.13582
Verdura S, Encinar JA, Gratchev A, Llop-Hernández À, López J, Serrano-Hervás E, Teixidor E, López-Bonet E, Martin-Castillo B, Micol V, Bosch-Barrera J, Cuyàs E, Menendez JA

Silibinin is a suppressor of the metastasis-promoting transcription factor ID3

Phytomedicine, 2024, 128, 155493-155493 dx.doi.org/10.1016/j.phymed.2024.155493
Cuyàs E, Pedarra S, Verdura S, Pardo MA, Espin Garcia R, Serrano-Hervás E, Llop-Hernández À, Teixidor E, Bosch-Barrera J, López-Bonet E, Martin-Castillo B, Lupu R, Pujana MA, Sardanyès J, Alarcón T, Menendez JA

Fatty acid synthase (FASN) is a tumor-cell-intrinsic metabolic checkpoint restricting T-cell immunity.

Cell Death Discovery, 2024, 10, 417-417 dx.doi.org/10.1038/s41420-024-02184-z
Teixidor-Vilà E, Trallero J, Puigdemont M, Vidal-Vila A, Hernandez-Martínez A, Sais E, Sabaté-Ortega J, Verdura S, Menendez JA, Bosch-Barrera J, Sanvisens A, Marcos-Gragera R

Lung cancer survival trends and prognostic factors: A 26-year population-based study in Girona Province, Spain.

LUNG CANCER, 2024, 197, 107995-107995 dx.doi.org/10.1016/j.lungcan.2024.107995
Canet-Hermida J, Marín F, Dorca E, Dueñas N, Costa L, Salinas M, Velasco À, Peremiquel-Trillas P, Paytubi S, Ponce J, Fernández S, Martínez JM, Cárdenas L, Taltavull A, Alemany L, Meléndez C, Oliveras G, Vidal A, Capellá G, López-Bonet E, Brunet J, Matias-Guiu X, Pineda M

Highly Sensitive Microsatellite Instability and Immunohistochemistry Assessment in Endometrial Aspirates as a Tool for Cancer Risk Individualization in Lynch Syndrome

MODERN PATHOLOGY, 2023, 36, 100158-100158 dx.doi.org/10.1016/j.modpat.2023.100158
Teixidor E, Sais E, Vásquez CA, Carbajal W, Hernández A, Sánchez G, Izquierdo A, Verdura S, Menéndez JA, Bosch-Barrera J

Addendum: Immune-related adverse events and atypical radiological response with checkpoint inhibitor immunotherapy in an elderly patient with high PD-L1 expressing lung adenocarcinoma.

Oncotarget, 2023, 14, 668-668 dx.doi.org/10.18632/oncotarget.28471
Cuyàs, E, Verdura, S, Martin-Castillo, B, Menendez, JA

Circulating levels of MOTS-c in patients with breast cancer treated with metformin

Aging-Us, 2023, 15, 892-897
Bosch-Barrera, J, Teixidor, E, Sanvisens, A, Puigdemont, M, Trallero, J, Vila, AV, Osca, G, Roberte, MV, Priego, N, Sais, E, Martínez, AH, Ortega, JS, Cuyàs, E, Verdura, S, Puig, J, Pineda, V, Martí-Navas, M, Calvo, A, Menendez, JA, Marcos-Gragera, R, Valiente, M

Using Silibinin to Target STAT3-Positive Reactive Astrocytes for the Treatment of NSCLC Brain Metastases

JOURNAL OF THORACIC ONCOLOGY, 2023, 18, 426-427
Bosch-Barrera J, Roqué A, Teixidor E, Carmona-Garcia MC, Arbusà A, Brunet J, Martin-Castillo B, Cuyàs E, Verdura S, Menendez JA

Clinical Management of COVID-19 in Cancer Patients with the STAT3 Inhibitor Silibinin

Pharmaceuticals, 2022, 15 dx.doi.org/10.3390/ph15010019
Competitive projects
Metabolism and Cancer

Ayuda de personal Miquel Servet

Codi oficial: CP20/00003 Start date:01/01/2021 Data fi: 31/12/2025 Investigador/a principal: ELISABET CUYÀS NAVARRO, JAVIER ABEL MENÉNDEZ MENÉNDEZ Organisme finançador: INSTITUTO DE SALUD CARLOS III
Metabolism and Cancer

Ajuts per donar suport a les activitats dels grups de recerca de Catalunya (SGR-Cat 2021) - Metabolisme i càncer

Codi oficial: 2021 SGR 01507 Start date:01/01/2022 Data fi: 30/06/2025 Investigador/a principal: BEGOÑA MARTIN CASTILLO Organisme finançador: AGÈNCIA DE GESTIÓ UNIVERSITARIS I RECERCA
Metabolism and Cancer

Un nuevo enfoque de la actividad ácido graso sintasa como sistema de procesamiento de información en la oncología de precisión funcional

Codi oficial: PID2022-141955OB-I00 Start date:17/10/2023 Data fi: 31/08/2026 Investigador/a principal: JAVIER ABEL MENÉNDEZ MENÉNDEZ Organisme finançador: MINISTERIO DE ECONOMIA E INNOVACION
Metabolism and Cancer

Modificaciones postraduccionales de PD-L1 en la inmunoterapia del cáncer: Desarrollo de nuevas estrategias terapéuticas y fármaco-diagnósticas

Codi oficial: PI22/00297 Start date:01/01/2023 Data fi: 31/12/2025 Investigador/a principal: JAVIER ABEL MENÉNDEZ MENÉNDEZ, ELISABET CUYÀS NAVARRO Organisme finançador: INSTITUTO DE SALUD CARLOS III
Metabolism and Cancer

Ayuda de personal PFIS

Codi oficial: FI23/00043 Start date:01/01/2024 Data fi: 31/12/2027 Investigador/a principal: ELISABET CUYÀS NAVARRO, JÚLIA LÓPEZ ROMERO Organisme finançador: INSTITUTO DE SALUD CARLOS III
Transfer
Patents

Valiente Cortés Manuel, Priego Bendeck Neibla, Bosch Barrera Joaquim
MEANS FOR PREVENTING AND TREATING BRAIN METASTASIS
Número de publicació: EP20170382891
Data de publicació: 2019-06-26

Clinical Guidelines

- Nadal E,Bosch Barrera J,Cedrés S,Coves J,García Campelo R,Guirado M,López Castro R,Ortega AL,Vicente D,de Castro Carpeño J. SEOM clinical guidelines for the treatment of malignant pleural mesothelioma (2020).Clin Transl Oncol. 2021. 23. (5):p. 980-987. IF:3,405. (Q3).

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