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The main research focus of our group involves an Integrative Systems Medicine approach, with a particular emphasis on understanding the role of the gut microbiome in ageing, cognitive performance, and metabolic and mental health. To achieve our objectives, we undertake highly multidisciplinary research that combines cutting-edge post-genomic technologies—including shotgun metagenomics, NMR and HPLC-MS/MS metabolomics and lipidomics, and RNA sequencing, among others—with advanced computational bioinformatic techniques such as machine learning, chemometrics, and multivariate statistics.

The group has extensive experience in bioinformatic analysis of single-omics datasets and integrating omics data. Our research is conducted on large human cohorts and validate our findings using pre-clinical models such as mice and Drosophila melanogaster.

Our ultimate goal is to mine and integrate high-throughput omics and clinical data to obtain a holistic understanding of the complex host-microbiome interactions and the multifactorial, heterogeneous nature of non-communicable diseases. Through this work, we seek to elucidate the molecular mechanisms underlying health and disease. We strive to identify new biomarkers or signatures that can serve as the foundation for developing efficient personalized, tailor-made therapies, as well as diagnostic, prognostic, and monitoring tools for clinical translation.

Main lines of research

- Role of the microbiome on metabolic health (e.g., obesity, MASLD, diabetes), behaviour (food addiction), cognitive performance, mental health (depression, anxiety), and neurodegenerative disorders (Alzheimer’s disease)

- Influence of non-bacterial biomes (viruses, archaea, protists, and fungi) in cognition and metabolic and mental health

- Gut microbial metabolism of histidine in MASLD and other obesity-related metabolic diseases

- Gut microbial regulation of tryptophan metabolism in cognition and mental and metabolic health.

- Impact of the microbiome-gut-brain axis and the fat-brain axis on depression

- Role of the gut microbiome in the early stage and progression of Alzheimer’s disease

- Role and mechanisms of the gut microbiome in ageing and age-related cognitive decline

- Influence of the gut bacteria and viruses on food addiction.

Strategic objectives

Our key objectives are:

  • Understanding the complex nature of non-communicable disease (obesity, diabetes, MASLD, mental and neurological disorders)
  • Elucidating the role of the intricate host-microbiome interactions
  • Unravelling the underlying molecular mechanisms
  • Developing more efficient, personalized, tailor-made, and easily accessible treatment options, as well as better diagnostic, prognostic, and monitoring tools.

To achieve these objectives, we aim to:

  • Incorporate a pan-kingdom view of the microbiome (including largely neglected members such as viruses or eukaryote) and conduct a thorough functional profiling (combining metagenomics with metabolomics), to effectively capture host-microbiome interactions.
  • Identify single-omics signatures in longitudinal and large-scale cohorts.
  • Validate the identified profiles in independent cohorts.
  • Integrate single-omics profiles with clinical and neuroimaging data (MRI-based radiomics) to obtain a holistic picture of the mechanisms underlying the gut microbiome-host interactions.
  • Assess the potential causal role of the gut microbiota species/genes, their metabolites, and miRNAs in cells, mouse (e.g. Fecal Microbiome and Viral Transplantations) and fly models (e.g. mono-colonization with candidate species, dietary supplementation with selected metabolites, etc).
Publications
Rosell-Díaz M, Santos-González E, Motger-Albertí A, Gallardo-Nuell L, Arnoriaga-Rodríguez M, Coll-Martínez C, Ramió-Torrentà L, Garre-Olmo J, Puig J, Ramos R, Mayneris-Perxachs J, Manuel Fernández-Real J

Lower serum ferritin levels are associated with worse cognitive performance in aging

JOURNAL OF NUTRITION HEALTH & AGING, 2024, 28, 100190-100190 dx.doi.org/10.1016/j.jnha.2024.100190
Mayneris-Perxachs J, Castells-Nobau A, Fernández-Real JM

"Indole-gence"for the mind

CELL HOST & MICROBE, 2024, 32, 151-153 dx.doi.org/10.1016/j.chom.2024.01.006
Rosell-Díaz M, Petit-Gay A, Molas-Prat C, Gallardo-Nuell L, Ramió-Torrentà L, Garre-Olmo J, Pérez-Brocal V, Moya A, Jové M, Pamplona R, Puig J, Ramos R, Bäckhed F, Mayneris-Perxachs J, Fernández-Real JM

Metformin-induced changes in the gut microbiome and plasma metabolome are associated with cognition in men.

METABOLISM-CLINICAL AND EXPERIMENTAL, 2024, 157, 155941-155941 dx.doi.org/10.1016/j.metabol.2024.155941
Samulenaite S, García-Blanco A, Mayneris-Perxachs J, Domingo-Rodríguez L, Cabana-Domínguez J, Fernàndez-Castillo N, Gago-García E, Pineda-Cirera L, Burokas A, Espinosa-Carrasco J, Arboleya S, Latorre J, Stanton C, Hosomi K, Kunisawa J, Cormand B, Fernández-Real JM, Maldonado R, Martín-García E

Gut microbiota signatures of vulnerability to food addiction in mice and humans.

Gut, 2024 dx.doi.org/10.1136/gutjnl-2023-331445
Milbank E, Díaz-Trelles R, Dragano N, Latorre J, Mukthavaram R, Mayneris-Perxachs J, Ortega F, Federici M, Burcelin R, Karmali PP, Tachikawa K, Chivukula P, López M, Fernández-Real JM, Moreno-Navarrete JM

Liver lipopolysaccharide binding protein prevents hepatic inflammation in physiological and pathological non-obesogenic conditions

PHARMACOLOGICAL RESEARCH, 2023, 187, 106562-106562 dx.doi.org/10.1016/j.phrs.2022.106562
Paton B, Foguet-Romero E, Suarez M, Mayneris-Perxachs J, Boqué N, Caimari A, Canela N, Herrero P

Brain N-Glycosylation and Lipidomic Profile Changes Induced by a High-Fat Diet in Dyslipidemic Hamsters

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 dx.doi.org/10.3390/ijms24032883
Sol J, Obis È, Mota-Martorell N, Pradas I, Galo-Licona JD, Martin-Garí M, Fernández-Bernal A, Ortega-Bravo M, Mayneris-Perxachs J, Borrás C, Viña J, de la Fuente M, Mate I, Biarnes C, Pedraza S, Vilanova JC, Brugada R, Ramos R, Serena J, Ramió-Torrentà L, Pineda V, Daunis-I-Estadella P, Thió-Henestrosa S, Barretina J, Garre-Olmo J, Portero-Otin M, Fernández-Real JM, Puig J, Jové M, Pamplona R

Plasma acylcarnitines and gut-derived aromatic amino acids as sex-specific hub metabolites of the human aging metabolome

Aging Cell, 2023, 22 dx.doi.org/10.1111/acel.13821
Mayneris-Perxachs J, Fernández-Real JM

Proline-related metabolites: Towards biological diagnosis of depression

PSYCHIATRY AND CLINICAL NEUROSCIENCES, 2023, 77, 195-195 dx.doi.org/10.1111/pcn.13535
Arnoriaga-Rodríguez M, Leal Y, Mayneris-Perxachs J, Pérez-Brocal V, Moya A, Ricart W, Fernández-Balsells M, Fernández-Real JM

Gut Microbiota Composition and Functionality Are Associated With REM Sleep Duration and Continuous Glucose Levels

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2023, 108, 2931-2939 dx.doi.org/10.1210/clinem/dgad258
Swann JR, Diaz Heijtz R, Mayneris-Perxachs J, Arora A, Isaksson J, Bölte S, Tammimies K

Characterizing the metabolomic signature of attention-deficit hyperactivity disorder in twins

Neuropharmacology, 2023, 234, 109562-109562 dx.doi.org/10.1016/j.neuropharm.2023.109562
Competitive projects
Codi oficial: PI20/01090 Start date:01/01/2021 Data fi: 31/12/2024 Investigador/a principal: JORDI MAYNERIS PERXACHS Organisme finançador: INSTITUTO DE SALUD CARLOS III
Codi oficial: UKRI Cognitive Decline Start date:01/01/2022 Data fi: 31/12/2024 Investigador/a principal: JORDI MAYNERIS PERXACHS Organisme finançador: UK RESEARCH AND INNOVATION (UKRI)
Codi oficial: 2023_FI_1 00515 Sara Pauli Start date:01/06/2023 Data fi: 31/05/2026 Investigador/a principal: JORDI MAYNERIS PERXACHS, SARA PAULÍ I PLA Organisme finançador: AGÈNCIA DE GESTIÓ UNIVERSITARIS I RECERCA (AGAUR)
Codi oficial: PI23/00575 Start date:01/01/2024 Data fi: 31/12/2026 Investigador/a principal: JORDI MAYNERIS PERXACHS Organisme finançador: INSTITUTO DE SALUD CARLOS III
Codi oficial: CNS2023-144218 Start date:01/04/2024 Data fi: 30/06/2026 Investigador/a principal: JORDI MAYNERIS PERXACHS Organisme finançador: MINISTERIO DE ECONOMIA Y COMPETITIVIDAD MINECO /
Codi oficial: 2023_IBEC_JMP Start date:01/03/2024 Data fi: 30/06/2025 Investigador/a principal: JORDI MAYNERIS PERXACHS Organisme finançador: FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
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