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A centre dedicated to the study of diseases associated with sudden death.

The CGC's research aims to improve knowledge of the associated factors and basic mechanisms that cause cardiovascular disease and sudden death and improve the tools for its diagnostic, prevention, and treatment.

This scientific area is divided into a clinical research area and a basic research area.

CLINICAL RESEARCH: The clinical research program takes advantage of the collaboration of hospitals and health centres to study risk factors, possible treatments, and prevention methods.

BASIC RESEARCH: Studies aimed at better understanding the biological bases of diseases associated with sudden death. The laboratory participates in different projects to understand the physio pathological basis of sudden death in six major aspects: Genetics, epigenetics, histology, electrophysiology, membrane trafficking and proteomics.

Visita la web de Gencardio Diagnostics

Main lines of research

Genetic and molecular bases of sudden cardiac death.

Strategic objectives
  • Promote research, teaching and health care quality in the field of heart disease, especially in those that can cause arrhythmias and sudden death
  • Carry out a basic and clinical research program dedicated to cardiovascular disease.
  • The research program is based on the synergy provided by the different specialisms within the group.
  • Provide high-level medical assistance thanks to the incorporation of genetic technology into current methods of diagnosis and treatment.
  • Genetic results allow complementing clinical tests, often insufficient to reach a diagnosis, and customizing treatment options.
  • Develop new genetic tools that improve the diagnosis of patients at risk of cardiovascular disease. Main lines of research
  • Genetic and molecular bases of sudden cardiac death.
Publications

Escrichs A, Biarnes C, Garre-Olmo J, Fernández-Real JM, Ramos R, Pamplona R, Brugada R, Serena J, Ramió-Torrentà L, Coll-De-Tuero G, Gallart L, Barretina J, Vilanova JC, Mayneris-Perxachs J, Essig M, Figley CR, Pedraza S, Puig J, Deco G

Whole-Brain Dynamics in Aging: Disruptions in Functional Connectivity and the Role of the Rich Club.

CEREBRAL CORTEX, 2021, 31, 2466-2481 dx.doi.org/10.1093/cercor/bhaa367

Garre-Olmo J, Turró-Garriga O, Martí-Lluch R, Zacarías-Pons L, Alves-Cabratosa L, Serrano-Sarbosa D, Vilalta-Franch J, Ramos R, Girona Healthy Region Study Group

Changes in lifestyle resulting from confinement due to COVID-19 and depressive symptomatology: A cross-sectional a population-based study.

COMPREHENSIVE PSYCHIATRY, 2021, 104, 152214-152214 dx.doi.org/10.1016/j.comppsych.2020.152214

Vallverdú-Prats M, Alcalde M, Sarquella-Brugada G, Cesar S, Arbelo E, Fernandez-Falgueras A, Coll M, Pérez-Serra A, Puigmulé M, Iglesias A, Fiol V, Ferrer-Costa C, Olmo BD, Picó F, Lopez L, Jordà P, García-Álvarez A, Llano CT, Toro R, Grassi S, Oliva A, Brugada J, Brugada R, Campuzano O

Rare Variants Associated with Arrhythmogenic Cardiomyopathy: Reclassification Five Years Later.

Journal of Personalized Medicine, 2021, 11, 162 dx.doi.org/10.3390/jpm11030162

Puig J, Biarnes C, Pedraza S, Vilanova JC, Pamplona R, Fernández-Real JM, Brugada R, Ramos R, Coll-De-Tuero G, Calvo-Perxas L, Serena J, Ramió-Torrentà L, Gich J, Gallart L, Portero-Otin M, Alberich-Bayarri A, Jimenez-Pastor A, Camacho-Ramos E, Mayneris-Perxachs J, Pineda V, Font R, Prats-Puig A, Gacto ML, Deco G, Escrichs A, Clotet B, Paredes R, Negredo E, Triaire B, Rodríguez M, Heredia-Escámez A, Coronado R, de Graaf W, Prevost V, Mitulescu A, Daunis-I-Estadella P, Thió-Henestrosa S, Miralles F, Ribas-Ripoll V, Puig-Domingo M, Essig M, Figley CR, Figley TD, Albensi B, Ashraf A, Reiber JHC, Schifitto G, Md Nasir U, Leiva-Salinas C, Wintermark M, Nael K, Vilalta-Franch J, Barretina J, Garre-Olmo J

The Aging Imageomics Study: rationale, design and baseline characteristics of the study population.

MECHANISMS OF AGEING AND DEVELOPMENT, 2020, 189, 111257-111257 dx.doi.org/10.1016/j.mad.2020.111257

Rigau PV, Moral S, Bosch D, Morales M, Frigola JM, Albert X, Robles R, Ballesteros E, Roqué M, Aboal J, Brugada R

Clinical Prognosis of Right-Sided Infective Endocarditis not Associated with Cardiac Devices or Intravenous Drug use: a Cohort Study and Meta-Analysis.

SCIENTIFIC REPORTS, 2020, 10, 7179-7179 dx.doi.org/10.1038/s41598-020-64220-z

Campuzano O, Fernandez-Falgueras A, Lemus X, Sarquella-Brugada G, Cesar S, Coll M, Mates J, Arbelo E, Jordà P, Perez-Serra A, Del Olmo B, Ferrer-Costa C, Iglesias A, Fiol V, Puigmulé M, Lopez L, Pico F, Brugada J, Brugada R

Short QT Syndrome: A Comprehensive Genetic Interpretation and Clinical Translation of Rare Variants.

Journal of Clinical Medicine, 2019, 8, 1035 dx.doi.org/10.3390/jcm8071035

Campuzano O, Sarquella-Brugada G, Fernandez-Falgueras A, Cesar S, Coll M, Mates J, Arbelo E, Perez-Serra A, Del Olmo B, Jordá P, Fiol V, Iglesias A, Puigmulé M, Lopez L, Pico F, Brugada J, Brugada R

Genetic interpretation and clinical translation of minor genes related to Brugada syndrome.

HUMAN MUTATION, 2019, 40, 749-764 dx.doi.org/10.1002/humu.23730

Campuzano O, Fernandez-Falgueras A, Sarquella-Brugada G, Cesar S, Arbelo E, García-Álvarez A, Jordà P, Coll M, Fiol V, Iglesias A, Perez-Serra A, Mates J, Del Olmo B, Ferrer C, Alcalde M, Puigmulé M, Mademont-Soler I, Pico F, Lopez L, Tiron C, Brugada J, Brugada R

Personalized Interpretation and Clinical Translation of Genetic Variants Associated With Cardiomyopathies.

Frontiers in Genetics, 2019, 10, 450-450 dx.doi.org/10.3389/fgene.2019.00450

Cuyàs E, Gumuzio J, Lozano-Sánchez J, Carreras D, Verdura S, Llorach-Parés L, Sanchez-Martinez M, Selga E, Pérez GJ, Scornik FS, Brugada R, Bosch-Barrera J, Segura-Carretero A, Martin ÁG, Encinar JA, Menendez JA

Extra Virgin Olive Oil Contains a Phenolic Inhibitor of the Histone Demethylase LSD1/KDM1A.

Nutrients, 2019, 11, 1656 dx.doi.org/10.3390/nu11071656

Paz MA, Farrerons M, Saez M, Saurina C, Pinto MG, Castro S, Sobrino J, de Tuero GC

Practical application of the ATOM study: Treatment efficacy of antihypertensive drugs in monotherapy or combination (ATOM metaanalysis according to PRISMA statement); tables for the use of antihypertensive drugs in monotherapy or combination.

Medicine, 2019, 98, e15010 dx.doi.org/10.1097/MD.0000000000015010
Competitive projects
Codi oficial: FI18/00321 Start date:01/01/2019 Data fi: 31/12/2022 Investigador/a principal: RAMON BRUGADA TARRADELLAS Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 82,400 €
Codi oficial: MV20/00091 Start date:01/01/2021 Data fi: 31/12/2021 Investigador/a principal: RAMON BRUGADA TARRADELLAS Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 15,755 €
Codi oficial: SEC/FEC-INV-BAS 20/003 Start date:28/10/2020 Data fi: 31/12/2024 Investigador/a principal: OSCAR CAMPUZANO LARREA Organisme finançador: SEC- SOCIEDAD ESPAÑOLA DE CARDIOLOGIA Ajuda: 15,000 €
Codi oficial: GINA-COVID Start date:20/07/2021 Data fi: 30/07/2024 Investigador/a principal: RAMON BRUGADA TARRADELLAS Organisme finançador: FUNDACIO LA MARATO TV3 Ajuda: 116,997.50 €
Codi oficial: 101046118 Start date:01/12/2021 Data fi: 31/05/2024 Investigador/a principal: RAMON BRUGADA TARRADELLAS Organisme finançador: EUROPEAN COMISSION Ajuda: 378,125 €
Codi oficial: Grant/2021/PHF/23776 Start date:03/09/2021 Data fi: 30/09/2022 Investigador/a principal: RAMON BRUGADA TARRADELLAS Organisme finançador: EUROPEAN CENTRE FOR DISEASE PREVENTION AND CONTROL (ECDC) Ajuda: 67,867.28 €
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