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A centre dedicated to the study of diseases associated with sudden death.

The CGC's research aims to improve knowledge of the associated factors and basic mechanisms that cause cardiovascular disease and sudden death and improve the tools for its diagnostic, prevention, and treatment.

This scientific area is divided into a clinical research area and a basic research area.

CLINICAL RESEARCH: The clinical research program takes advantage of the collaboration of hospitals and health centres to study risk factors, possible treatments, and prevention methods.

BASIC RESEARCH: Studies aimed at better understanding the biological bases of diseases associated with sudden death. The laboratory participates in different projects to understand the physio pathological basis of sudden death in six major aspects: Genetics, epigenetics, histology, electrophysiology, membrane trafficking and proteomics.

Visit Gencardio Diagnostics' website

Main lines of research

Genetic and molecular bases of sudden cardiac death.

Strategic objectives
  • Promote research, teaching and health care quality in the field of heart disease, especially in those that can cause arrhythmias and sudden death
  • Carry out a basic and clinical research program dedicated to cardiovascular disease.
  • The research program is based on the synergy provided by the different specialisms within the group.
  • Provide high-level medical assistance thanks to the incorporation of genetic technology into current methods of diagnosis and treatment.
  • Genetic results allow complementing clinical tests, often insufficient to reach a diagnosis, and customizing treatment options.
  • Develop new genetic tools that improve the diagnosis of patients at risk of cardiovascular disease. Main lines of research
  • Genetic and molecular bases of sudden cardiac death.
Publications
Marcos MC, De La Espriella R, Ordás JG, Llàcer P, Pomares A, Fort A, De Antonio IP, Méndez A, Bermejo ZB, Pérez PC, Gracia JR, Mayoral AR, Zegrí I, García Pinilla JM, Hernández EM, Castro A, Soler MJ, Górriz JL, Claret RB, Brugués PF, Manzano L, Núñez J

Prevalence and clinical profile of kidney disease in patients with chronic heart failure. Insights from the Spanish cardiorenal registry.

REVISTA ESPANOLA DE CARDIOLOGIA, 2024, 77, 50-59 dx.doi.org/10.1016/j.rec.2023.05.003
Martínez-Moreno R, Carreras D, Sarquella-Brugada G, Pérez GJ, Selga E, Scornik FS, Brugada R

Loss of sodium current caused by a Brugada syndrome-associated variant is determined by patient-specific genetic background.

Heart Rhythm, 2024, 21, 331-339 dx.doi.org/10.1016/j.hrthm.2023.11.019
Aboal J, Pascual J, Loma-Osorio P, Nuñez M, Badosa E, Martín C, Ferrero M, Moral S, Ballesteros E, Pedraza J, Tapia S, Brugada R

Impact of a Cardiogenic Shock Program on Mortality in a Non-Transplant Hospital.

HEART LUNG CIRC, 2024, 33, 38-45 dx.doi.org/10.1016/j.hlc.2023.11.010
Camps-Vilaró A, Pinsach-Abuin ML, Degano IR, Ramos R, Martí-Lluch R, Elosua R, Subirana I, Solà-Richarte C, Puigmulé M, Pérez A, Vilaró I, Cruz R, Diz-de Almeida S, Nogues X, Masclans JR, Güerri-Fernández R, Marin J, Tizon-Marcos H, Vaquerizo B, Brugada R, Marrugat J

Genetic characteristics involved in COVID-19 severity. The CARGENCORS case-control study and meta-analysis.

J MED VIROL, 2024, 96 dx.doi.org/10.1002/jmv.29404
Biener L, Vogelhuber J, Alboany H, Tiyerili V, Weber M, Linhart M, Becher MU, Schenk A, Nickenig G, Skowasch D, Pizarro C

Prevalence of sleep-disordered breathing in patients with mitral regurgitation and the effect of mitral valve repair

SLEEP AND BREATHING, 2023, 27, 599-610 dx.doi.org/10.1007/s11325-022-02667-2
Muñoz-San Martín M, Gómez I, Quiroga-Varela A, Gonzalez-Del Río M, Robles Cedeño R, Álvarez G, Buxó M, Miguela A, Villar LM, Castillo-Villalba J, Casanova B, Quintana E, Ramió-Torrentà L

miRNA Signature in CSF From Patients With Primary Progressive Multiple Sclerosis.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION, 2023, 10 dx.doi.org/10.1212/NXI.0000000000200069
Martinez-Barrios E, Sarquella-Brugada G, Perez-Serra A, Fernandez-Falgueras A, Cesar S, Alcalde M, Coll M, Puigmulé M, Iglesias A, Ferrer-Costa C, Del Olmo B, Picó F, Lopez L, Fiol V, Cruzalegui J, Hernandez C, Arbelo E, Díez-Escuté N, Cerralbo P, Grassi S, Oliva A, Toro R, Brugada J, Brugada R, Campuzano O

Reevaluation of ambiguous genetic variants in sudden unexplained deaths of a young cohort.

INTERNATIONAL JOURNAL OF LEGAL MEDICINE, 2023, 137, 345-351 dx.doi.org/10.1007/s00414-023-02951-0
Moral S, Abulí M, Méndez I, González-Gómez A, García-Quintana A, Menduiña I, Payá R, Esteban E, Sánchez PL, Díaz E, de la Morena G, Calvo-Iglesias F, Gallego P, Ballesteros E, Brugada R, Evangelista A

Invasive management of significant tricuspid regurgitation in clinical practice.

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2023, 375, 66-73 dx.doi.org/10.1016/j.ijcard.2023.01.005
Vallverdú-Prats M, Carreras D, Pérez GJ, Campuzano O, Brugada R, Alcalde M

Alterations in Calcium Handling Are a Common Feature in an Arrhythmogenic Cardiomyopathy Cell Model Triggered by Desmosome Genes Loss.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 dx.doi.org/10.3390/ijms24032109
Milman A, Sabbag A, Conte G, Postema PG, Andorin A, Gourraud JB, Sacher F, Mabo P, Kim SH, Maeda S, Takahashi Y, Kamakura T, Aiba T, Juang JJ, Michowitz Y, Leshem E, Mizusawa Y, Arbelo E, Huang Z, Denjoy I, Giustetto C, Wijeyeratne YD, Mazzanti A, Brugada R, Casado-Arroyo R, Champagne J, Calo L, Sarquella-Brugada G, Tfelt-Hansen J, Priori SG, Takagi M, Veltmann C, Delise P, Corrado D, Behr ER, Gaita F, Yan GX, Brugada J, Leenhardt A, Wilde AAM, Brugada P, Kusano KF, Hirao K, Nam GB, Probst V, Belhassen B

Characteristics of Patients with Spontaneous Versus Drug-Induced Brugada Electrocardiogram: Sub-Analysis From the SABRUS.

CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, 2023, 16, 62-64 dx.doi.org/10.1161/CIRCEP.122.011360
Competitive projects
Codi oficial: SEC/FEC-INV-BAS 20/003 Start date:28/10/2020 Data fi: 31/12/2024 Investigador/a principal: OSCAR CAMPUZANO LARREA, RAMON BRUGADA TERRADELLAS Organisme finançador: SOCIEDAD ESPAÑOLA DE CARDIOLOGIA
Codi oficial: GINA-COVID Start date:20/07/2021 Data fi: 30/07/2024 Investigador/a principal: RAMON BRUGADA TERRADELLAS Organisme finançador: FUNDACIO LA MARATO TV3
Codi oficial: 101057509 Start date:01/11/2022 Data fi: 31/10/2027 Investigador/a principal: JOAN BRUNET VIDAL, RAMON BRUGADA TERRADELLAS, RAMON BRUGADA TERRADELLAS Organisme finançador: EUROPEAN COMISSION
Codi oficial: SLT021/21/000015 Start date:01/04/2022 Data fi: 31/12/2024 Investigador/a principal: RAMON BRUGADA TERRADELLAS Organisme finançador: GENERALITAT DE CATALUNYA
Codi oficial: PI22/00422 Start date:01/01/2023 Data fi: 31/12/2025 Investigador/a principal: RAMON BRUGADA TERRADELLAS, MIREIA ALCALDE MASEGÚ Organisme finançador: INSTITUTO DE SALUD CARLOS III
Codi oficial: SGR-Cat 2021 - Genètica Cardiovascular (Gencardio) Start date:01/01/2022 Data fi: 30/06/2025 Investigador/a principal: RAMON BRUGADA TERRADELLAS Organisme finançador: AGENCIA DE GESTIO D'AJUTS UNIV. I RECER.
Codi oficial: Girona, territori cardioprotegit Start date:01/07/2022 Data fi: 31/10/2025 Investigador/a principal: RAMON BRUGADA TERRADELLAS Organisme finançador: DIPUTACIO DE GIRONA
Codi oficial: SLT028/23/000317 Start date:01/08/2023 Data fi: 31/12/2025 Investigador/a principal: RAMON BRUGADA TERRADELLAS Organisme finançador: GENERALITAT DE CATALUNYA
Codi oficial: Estudi CIBER-SPANISH I Start date:15/01/2024 Data fi: 15/05/2028 Investigador/a principal: RAMON BRUGADA TERRADELLAS
Codi oficial: FI23/00047 Start date:01/01/2024 Data fi: 31/12/2027 Investigador/a principal: ESTEL ARTIGAS MELEIRO Organisme finançador: INSTITUTO DE SALUD CARLOS III
Codi oficial: PI21/00857 Start date:01/01/2022 Data fi: 31/12/2024 Investigador/a principal: MARIA-EMILCE TRUCCO
Codi oficial: 230193 Start date:01/07/2023 Data fi: 30/06/2025 Investigador/a principal: JAIME ABOAL VIÑAS Organisme finançador: EUROPEAN COMISSION
Codi oficial: 2023_IDIBELL_JAV Start date:11/12/2023 Data fi: 11/12/2024 Investigador/a principal: JAIME ABOAL VIÑAS Organisme finançador: PROMCAT ALTERNATIVA SL
Codi oficial: 2023_I3PT_JAV Start date:26/01/2024 Data fi: 31/12/2024 Investigador/a principal: JAIME ABOAL VIÑAS Organisme finançador: FUNDACIÓN INSTITUTO DE INVESTIGACIÓN E INNOVACIÓN PARC TAULÍ
Codi oficial: 2023_FENIN_JAV Start date:16/05/2023 Data fi: 16/05/2024 Investigador/a principal: JAIME ABOAL VIÑAS Organisme finançador: FEDERACIÓN DE EMPRESAS DE TECNOLOGÍA SANITARIA
Codi oficial: Estudio PREV Start date:01/11/2021 Data fi: 31/12/2025 Investigador/a principal: ARANTXA ERASO URIÉN, SERGI MORAL TORRES Organisme finançador: FUNDACION MERCK SALUD
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