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A centre dedicated to the study of diseases associated with sudden death.

The CGC's research aims to improve knowledge of the associated factors and basic mechanisms that cause cardiovascular disease and sudden death and improve the tools for its diagnostic, prevention, and treatment.

This scientific area is divided into a clinical research area and a basic research area.

CLINICAL RESEARCH: The clinical research program takes advantage of the collaboration of hospitals and health centres to study risk factors, possible treatments, and prevention methods.

BASIC RESEARCH: Studies aimed at better understanding the biological bases of diseases associated with sudden death. The laboratory participates in different projects to understand the physio pathological basis of sudden death in six major aspects: Genetics, epigenetics, histology, electrophysiology, membrane trafficking and proteomics.

Visit Gencardio Diagnostics' website

Main lines of research

Genetic and molecular bases of sudden cardiac death.

Strategic objectives
  • Promote research, teaching and health care quality in the field of heart disease, especially in those that can cause arrhythmias and sudden death
  • Carry out a basic and clinical research program dedicated to cardiovascular disease.
  • The research program is based on the synergy provided by the different specialisms within the group.
  • Provide high-level medical assistance thanks to the incorporation of genetic technology into current methods of diagnosis and treatment.
  • Genetic results allow complementing clinical tests, often insufficient to reach a diagnosis, and customizing treatment options.
  • Develop new genetic tools that improve the diagnosis of patients at risk of cardiovascular disease. Main lines of research
  • Genetic and molecular bases of sudden cardiac death.
Publications
Biener L, Vogelhuber J, Alboany H, Tiyerili V, Weber M, Linhart M, Becher MU, Schenk A, Nickenig G, Skowasch D, Pizarro C

Prevalence of sleep-disordered breathing in patients with mitral regurgitation and the effect of mitral valve repair

SLEEP AND BREATHING, 2023, 27, 599-610 dx.doi.org/10.1007/s11325-022-02667-2
Muñoz-San Martín M, Gómez I, Quiroga-Varela A, Gonzalez-Del Río M, Robles Cedeño R, Álvarez G, Buxó M, Miguela A, Villar LM, Castillo-Villalba J, Casanova B, Quintana E, Ramió-Torrentà L

miRNA Signature in CSF From Patients With Primary Progressive Multiple Sclerosis.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION, 2023, 10 dx.doi.org/10.1212/NXI.0000000000200069
Martinez-Barrios E, Sarquella-Brugada G, Perez-Serra A, Fernandez-Falgueras A, Cesar S, Alcalde M, Coll M, Puigmulé M, Iglesias A, Ferrer-Costa C, Del Olmo B, Picó F, Lopez L, Fiol V, Cruzalegui J, Hernandez C, Arbelo E, Díez-Escuté N, Cerralbo P, Grassi S, Oliva A, Toro R, Brugada J, Brugada R, Campuzano O

Reevaluation of ambiguous genetic variants in sudden unexplained deaths of a young cohort.

INTERNATIONAL JOURNAL OF LEGAL MEDICINE, 2023, 137, 345-351 dx.doi.org/10.1007/s00414-023-02951-0
Moral S, Abulí M, Méndez I, González-Gómez A, García-Quintana A, Menduiña I, Payá R, Esteban E, Sánchez PL, Díaz E, de la Morena G, Calvo-Iglesias F, Gallego P, Ballesteros E, Brugada R, Evangelista A

Invasive management of significant tricuspid regurgitation in clinical practice.

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2023, 375, 66-73 dx.doi.org/10.1016/j.ijcard.2023.01.005
Vallverdú-Prats M, Carreras D, Pérez GJ, Campuzano O, Brugada R, Alcalde M

Alterations in Calcium Handling Are a Common Feature in an Arrhythmogenic Cardiomyopathy Cell Model Triggered by Desmosome Genes Loss.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 dx.doi.org/10.3390/ijms24032109
Milman A, Sabbag A, Conte G, Postema PG, Andorin A, Gourraud JB, Sacher F, Mabo P, Kim SH, Maeda S, Takahashi Y, Kamakura T, Aiba T, Juang JJ, Michowitz Y, Leshem E, Mizusawa Y, Arbelo E, Huang Z, Denjoy I, Giustetto C, Wijeyeratne YD, Mazzanti A, Brugada R, Casado-Arroyo R, Champagne J, Calo L, Sarquella-Brugada G, Tfelt-Hansen J, Priori SG, Takagi M, Veltmann C, Delise P, Corrado D, Behr ER, Gaita F, Yan GX, Brugada J, Leenhardt A, Wilde AAM, Brugada P, Kusano KF, Hirao K, Nam GB, Probst V, Belhassen B

Characteristics of Patients with Spontaneous Versus Drug-Induced Brugada Electrocardiogram: Sub-Analysis From the SABRUS.

CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, 2023, 16, 62-64 dx.doi.org/10.1161/CIRCEP.122.011360
Martínez-Barrios E, Grassi S, Brión M, Toro R, Cesar S, Cruzalegui J, Coll M, Alcalde M, Brugada R, Greco A, Ortega-Sánchez ML, Barberia E, Oliva A, Sarquella-Brugada G, Campuzano O

Molecular autopsy: Twenty years of post-mortem diagnosis in sudden cardiac death.

Frontiers in Medicine, 2023, 10, 1118585-1118585 dx.doi.org/10.3389/fmed.2023.1118585
Rodríguez A, Aboal J, Loma-Osorio P, Ramos R, Boada I

Design and deployment of ODISEA, an application for the myOcarDial infarction SafEtytrAnsfer of patients.

INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS, 2023, 172, 105020-105020 dx.doi.org/10.1016/j.ijmedinf.2023.105020
Viana-Tejedor A, Andrea-Riba R, Scardino C, Ariza-Solé A, Bañeras J, García-García C, Jiménez Mena M, Vila M, Martínez-Sellés M, Pastor G, García Acuña JM, Loma-Osorio P, García Rubira JC, Jorge Pérez P, Pastor P, Ferrera C, Noriega FJ, Pérez Macías N, Fernández-Ortiz A, Pérez-Villacastín J

Coronary angiography in patients without ST-segment elevation following out-of-hospital cardiac arrest. COUPE clinical trial.

REVISTA ESPANOLA DE CARDIOLOGIA, 2023, 76, 94-102 dx.doi.org/10.1016/j.rec.2022.05.013
Cesar S, Coll M, Fiol V, Fernandez-Falgueras A, Cruzalegui J, Iglesias A, Moll I, Perez-Serra A, Martínez-Barrios E, Ferrer-Costa C, Del Olmo B, Puigmulè M, Alcalde M, Lopez L, Pico F, Berrueco R, Brugada J, Zschaeck I, Natera-de Benito D, Carrera-García L, Exposito-Escudero J, Ortez C, Nascimento A, Brugada R, Sarquella-Brugada G, Campuzano O

LMNA-related muscular dystrophy: Identification of variants in alternative genes and personalized clinical translation.

Frontiers in Genetics, 2023, 14, 1135438-1135438 dx.doi.org/10.3389/fgene.2023.1135438
Competitive projects
Cardiovascular Genetics

Estudio de expresión del ARN en pacientes con miocardiopatía arritmogénica para la determinación del sustrato fisiopatológico inductor de arritmias

Codi oficial: SEC/FEC-INV-BAS 20/003 Start date:28/10/2020 Data fi: 31/12/2024 Investigador/a principal: OSCAR CAMPUZANO LARREA, RAMON BRUGADA TERRADELLAS Organisme finançador: SOCIEDAD ESPAÑOLA DE CARDIOLOGIA Ajuda: 15,000 €
Cardiovascular Genetics

Mendelian Randomization to assess causal genetic pathways leading to severe COVID-19 (GINA-COVID)

Codi oficial: GINA-COVID Start date:20/07/2021 Data fi: 30/07/2024 Investigador/a principal: RAMON BRUGADA TERRADELLAS Organisme finançador: FUNDACIO LA MARATO TV3 Ajuda: 116,997.50 €
Cardiovascular Genetics

Programa de prevenció de malalties cardiovasculars basat en el cribatge d'arteriopatia perifèrica asimptomàtica. (Health origram for prevention of cardiovascular diseases based on a risk screeNing strategy with Ankle-brachial index).

Codi oficial: SLT021/21/000015 Start date:01/04/2022 Data fi: 31/12/2024 Investigador/a principal: RAMON BRUGADA TERRADELLAS Organisme finançador: GENERALITAT DE CATALUNYA Ajuda: 8,400 €
Cardiovascular Genetics

Variabilidad fenotípica en la Miocardiopatía Arritmogénica: De los mecanismos moleculares a la práctica clínica

Codi oficial: PI22/00422 Start date:01/01/2023 Data fi: 31/12/2025 Investigador/a principal: RAMON BRUGADA TERRADELLAS, MIREIA ALCALDE MASEGÚ Organisme finançador: INSTITUTO DE SALUD CARLOS III Ajuda: 75,020 €
Cardiovascular Genetics

Ajuts per donar suport a les activitats dels grups de recerca de Catalunya (SGR-Cat 2021) - Genètica Cardiovascular (Gencardio)

Codi oficial: SGR-Cat 2021 - Genètica Cardiovascular (Gencardio) Start date:01/01/2022 Data fi: 31/12/2024 Investigador/a principal: RAMON BRUGADA TERRADELLAS Organisme finançador: AGENCIA DE GESTIO D'AJUTS UNIV. I RECER. Ajuda: 0 €
Cardiovascular Genetics

Implementció de la segona fase del programa Pm05 "Girona, territori cardioprotegit" - Isabel Ramió / Manjhot

Codi oficial: Girona, territori cardioprotegit Start date:01/07/2022 Data fi: 31/10/2025 Investigador/a principal: RAMON BRUGADA TERRADELLAS Organisme finançador: DIPUTACIO DE GIRONA Ajuda: 99,741.87 €
Cardiovascular Genetics

Estudio genetico de ultrasecuenciacion como herramienta de prevencion de arritmias malignas y muerte subita en poblacion joven deportista (IDIBGI.00204)

Codi oficial: EXP_75056 Start date:27/03/2023 Data fi: 30/11/2023 Investigador/a principal: OSCAR CAMPUZANO LARREA Organisme finançador: CONSEJO SUPERIOR DE DEPORTES Ajuda: 88,330 €
Cardiovascular Genetics

Ajuda de personal Suport als grups PERIS - Genètica Cardiovascular

Codi oficial: SLT028/23/000317 Start date:01/08/2023 Data fi: 31/12/2025 Investigador/a principal: RAMON BRUGADA TERRADELLAS Organisme finançador: GENERALITAT DE CATALUNYA Ajuda: 75,784.93 €
Cardiovascular Genetics

Reducción de descargas mediante ráfagas múltiples de estimulación antitaquicardia para taquicardias ventriculares rápidas en portadores de desfibrilador automático implantable

Codi oficial: PI21/00857 Start date:01/01/2022 Data fi: 31/12/2024 Investigador/a principal: MARIA-EMILCE TRUCCO
Cardiovascular Genetics

AI Scalable Solution for ST Myocardial Infarction

Codi oficial: 230193 Start date:01/07/2023 Data fi: 30/06/2025 Investigador/a principal: JAIME ABOAL VIÑAS Organisme finançador: EUROPEAN COMISSION Ajuda: 41,759.38 €
Cardiovascular Genetics

Impacto de un programa estructurado de ejercicio físico y control de factores de riesgo cardiovasculares en prevención primaria de cardiotoxicidad en pacientes con cáncer de mama sometidos a tratamientos cardiotóxicos: Estudio PREV

Codi oficial: Estudio PREV Start date:01/11/2021 Data fi: 31/12/2025 Investigador/a principal: ARANTXA ERASO URIÉN, SERGI MORAL TORRES Organisme finançador: FUNDACION MERCK SALUD Ajuda: 0 €
Job offers
Reference 048-2023 | Cardiovascular Genetics
Research Technician - Bioinformatics Data del termini d'inscripció: 20231009

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