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A centre dedicated to the study of diseases associated with sudden death.

The CGC's research aims to improve knowledge of the associated factors and basic mechanisms that cause cardiovascular disease and sudden death and improve the tools for its diagnostic, prevention, and treatment.

This scientific area is divided into a clinical research area and a basic research area.

CLINICAL RESEARCH: The clinical research program takes advantage of the collaboration of hospitals and health centres to study risk factors, possible treatments, and prevention methods.

BASIC RESEARCH: Studies aimed at better understanding the biological bases of diseases associated with sudden death. The laboratory participates in different projects to understand the physio pathological basis of sudden death in six major aspects: Genetics, epigenetics, histology, electrophysiology, membrane trafficking and proteomics.

Visit Gencardio Diagnostics' website

Main lines of research

Genetic and molecular bases of sudden cardiac death.

Strategic objectives
  • Promote research, teaching and health care quality in the field of heart disease, especially in those that can cause arrhythmias and sudden death
  • Carry out a basic and clinical research program dedicated to cardiovascular disease.
  • The research program is based on the synergy provided by the different specialisms within the group.
  • Provide high-level medical assistance thanks to the incorporation of genetic technology into current methods of diagnosis and treatment.
  • Genetic results allow complementing clinical tests, often insufficient to reach a diagnosis, and customizing treatment options.
  • Develop new genetic tools that improve the diagnosis of patients at risk of cardiovascular disease. Main lines of research
  • Genetic and molecular bases of sudden cardiac death.
Publications
Marcos MC, De La Espriella R, Ordás JG, Llàcer P, Pomares A, Fort A, De Antonio IP, Méndez A, Bermejo ZB, Pérez PC, Gracia JR, Mayoral AR, Zegrí I, García Pinilla JM, Hernández EM, Castro A, Soler MJ, Górriz JL, Claret RB, Brugués PF, Manzano L, Núñez J

Prevalence and clinical profile of kidney disease in patients with chronic heart failure. Insights from the Spanish cardiorenal registry

REVISTA ESPANOLA DE CARDIOLOGIA, 2024, 77, 50-59 dx.doi.org/10.1016/j.rec.2023.05.003
Martínez-Moreno R, Carreras D, Sarquella-Brugada G, Pérez GJ, Selga E, Scornik FS, Brugada R

Loss of sodium current caused by a Brugada syndrome-associated variant is determined by patient-specific genetic background

Heart Rhythm, 2024, 21, 331-339 dx.doi.org/10.1016/j.hrthm.2023.11.019
Aboal J, Pascual J, Loma-Osorio P, Nuñez M, Badosa E, Martín C, Ferrero M, Moral S, Ballesteros E, Pedraza J, Tapia S, Brugada R

Impact of a Cardiogenic Shock Program on Mortality in a Non-Transplant Hospital

HEART LUNG AND CIRCULATION, 2024, 33, 38-45 dx.doi.org/10.1016/j.hlc.2023.11.010
Camps-Vilaró A, Pinsach-Abuin ML, Degano IR, Ramos R, Martí-Lluch R, Elosua R, Subirana I, Solà-Richarte C, Puigmulé M, Pérez A, Vilaró I, Cruz R, Diz-de Almeida S, Nogues X, Masclans JR, Güerri-Fernández R, Marin J, Tizon-Marcos H, Vaquerizo B, Brugada R, Marrugat J

Genetic characteristics involved in COVID-19 severity. The CARGENCORS case-control study and meta-analysis

JOURNAL OF MEDICAL VIROLOGY, 2024, 96 dx.doi.org/10.1002/jmv.29404
Cazzato F, Grassi S, Brugada R, Oliva A

Letter to the editor regarding the article "Heart weight must not be measured before dissection during autopsies"

INTERNATIONAL JOURNAL OF LEGAL MEDICINE, 2024, 138, 1663-1665 dx.doi.org/10.1007/s00414-024-03189-0
Perez-Serra, A, Toro, R, Martinez-Barrios, E, Iglesias, A, Fernandez-Falgueras, A, Alcalde, M, Coll, M, Puigmule, M, del Olmo, B, Pico, F, Lopez, L, Arbelo, E, Cesar, S, Llano, CTD, Mangas, A, Brugada, J, Sarquella-Brugada, G, Brugada, R, Campuzano, O

Implementing a New Algorithm for Reinterpretation of Ambiguous Variants in Genetic Dilated Cardiomyopathy

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 dx.doi.org/10.3390/ijms25073807
Campuzano, O, Sarquella-Brugada, G, Brugada, R

Sudden unexplained death in young people: A family matter

POLISH HEART JOURNAL-KARDIOLOGIA POLSKA, 2024, 82, 361-362 dx.doi.org/10.33963/v.phj.99975
Fernandez-Falgueras, A, Coll, M, Iglesias, A, Tiron, C, Campuzano, O, Brugada, R

The importance of variant reinterpretation in inherited cardiovascular diseases: Establishing the optimal timeframe

Plos One, 2024, 19 dx.doi.org/10.1371/journal.pone.0297914
Fogaça-da-Mata, M, Martínez-Barrios, E, Jiménez-Montañés, L, Cruzalegui, J, Chipa-Ccasani, F, Greco, A, Cesar, S, Díez-Escuté, N, Cerralbo, P, Zschaeck, I, Adell, MC, Ayerza-Casas, A, Palanca-Arias, D, López, M, Campuzano, O, Brugada, J, Sarquella-Brugada, G

Brugada Syndrome and Pulmonary Atresia with Intact Interventricular Septum: Fortuitous Finding or New Genetic Connection?

GENES, 2024, 15 dx.doi.org/10.3390/genes15050638
Mademont-Soler I, Esteba-Castillo S, Jiménez-Xifra A, Alemany B, Ribas-Vidal N, Cutillas M, Coll M, Pinsach ML, Pagans S, Alcalde M, Viñas-Jornet M, Montero-Vale M, de Castro-Miró M, Rodríguez J, Armengol L, Queralt X, Obón M

Unexpected complexity in the molecular diagnosis of spastic paraplegia 11.

Molecular genetics & genomic medicine, 2024, 12, 2475-2475 dx.doi.org/10.1002/mgg3.2475
Competitive projects
Codi oficial: SEC/FEC-INV-BAS 20/003 Start date:28/10/2020 Data fi: 31/12/2024 Investigador/a principal: OSCAR CAMPUZANO LARREA, RAMON BRUGADA TERRADELLAS Organisme finançador: SOCIEDAD ESPAÑOLA DE CARDIOLOGIA
Codi oficial: GINA-COVID Start date:20/07/2021 Data fi: 30/07/2024 Investigador/a principal: RAMON BRUGADA TERRADELLAS Organisme finançador: FUNDACIO LA MARATO TV3
Codi oficial: 101057509 Start date:01/11/2022 Data fi: 31/10/2027 Investigador/a principal: JOAN BRUNET VIDAL, RAMON BRUGADA TERRADELLAS, RAMON BRUGADA TERRADELLAS Organisme finançador: EUROPEAN COMISSION
Codi oficial: SLT021/21/000015 Start date:01/04/2022 Data fi: 31/12/2024 Investigador/a principal: RAMON BRUGADA TERRADELLAS Organisme finançador: GENERALITAT DE CATALUNYA
Codi oficial: PI22/00422 Start date:01/01/2023 Data fi: 31/12/2025 Investigador/a principal: RAMON BRUGADA TERRADELLAS, MIREIA ALCALDE MASEGÚ Organisme finançador: INSTITUTO DE SALUD CARLOS III
Codi oficial: SGR-Cat 2021 - Genètica Cardiovascular (Gencardio) Start date:01/01/2022 Data fi: 30/06/2025 Investigador/a principal: RAMON BRUGADA TERRADELLAS Organisme finançador: AGÈNCIA DE GESTIÓ UNIVERSITARIS I RECERCA (AGAUR)
Codi oficial: Girona, territori cardioprotegit Start date:01/07/2022 Data fi: 31/10/2025 Investigador/a principal: RAMON BRUGADA TERRADELLAS Organisme finançador: DIPUTACIO DE GIRONA
Codi oficial: SLT028/23/000317 Start date:01/08/2023 Data fi: 31/12/2025 Investigador/a principal: RAMON BRUGADA TERRADELLAS Organisme finançador: GENERALITAT DE CATALUNYA
Codi oficial: Estudi CIBER-SPANISH I Start date:15/01/2024 Data fi: 15/05/2028 Investigador/a principal: RAMON BRUGADA TERRADELLAS
Codi oficial: FI23/00047 Start date:01/01/2024 Data fi: 31/12/2027 Investigador/a principal: RAMON BRUGADA TERRADELLAS, ESTEL ARTIGAS MELEIRO Organisme finançador: INSTITUTO DE SALUD CARLOS III
Codi oficial: PI21/00857 Start date:01/01/2022 Data fi: 31/12/2024 Investigador/a principal: MARIA-EMILCE TRUCCO
Codi oficial: ODISEA Start date:01/07/2022 Data fi: 31/12/2024 Investigador/a principal: JAIME ABOAL VIÑAS, CARMEN MARTIN DOMINGUEZ Organisme finançador: SOCIEDAD ESPAÑOLA DE CARDIOLOGIA
Codi oficial: 230193 Start date:01/07/2023 Data fi: 30/06/2025 Investigador/a principal: JAIME ABOAL VIÑAS Organisme finançador: EUROPEAN COMISSION
Codi oficial: 2023_IDIBELL_JAV Start date:11/12/2023 Data fi: 11/12/2024 Investigador/a principal: JAIME ABOAL VIÑAS Organisme finançador: PROMCAT ALTERNATIVA SL
Codi oficial: 2023_I3PT_JAV Start date:26/01/2024 Data fi: 31/12/2024 Investigador/a principal: JAIME ABOAL VIÑAS Organisme finançador: FUNDACIÓN INSTITUTO DE INVESTIGACIÓN E INNOVACIÓN PARC TAULÍ
Codi oficial: Estudio PREV Start date:01/11/2021 Data fi: 31/12/2025 Investigador/a principal: ARANTXA ERASO URIÉN, SERGI MORAL TORRES Organisme finançador: FUNDACION MERCK SALUD
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