Cardiovascular Genetics

A centre dedicated to the study of diseases associated with sudden death.

The CGC's research aims to improve knowledge of the associated factors and basic mechanisms that cause cardiovascular disease and sudden death and improve the tools for its diagnostic, prevention, and treatment.

This scientific area is divided into a clinical research area and a basic research area.

CLINICAL RESEARCH: The clinical research program takes advantage of the collaboration of hospitals and health centres to study risk factors, possible treatments, and prevention methods.

BASIC RESEARCH: Studies aimed at better understanding the biological bases of diseases associated with sudden death. The laboratory participates in different projects to understand the physio pathological basis of sudden death in six major aspects: Genetics, epigenetics, histology, electrophysiology, membrane trafficking and proteomics.

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Main lines of research

Genetic and molecular bases of sudden cardiac death.

Strategic objectives

Promote research, teaching and health care quality in the field of heart disease, especially in those that can cause arrhythmias and sudden death
Carry out a basic and clinical research program dedicated to cardiovascular disease.
The research program is based on the synergy provided by the different specialisms within the group.
Provide high-level medical assistance thanks to the incorporation of genetic technology into current methods of diagnosis and treatment.
Genetic results allow complementing clinical tests, often insufficient to reach a diagnosis, and customizing treatment options.
Develop new genetic tools that improve the diagnosis of patients at risk of cardiovascular disease. Main lines of research
Genetic and molecular bases of sudden cardiac death.

Publications

Cardiovascular Genetics

Marcos MC, De La Espriella R, Ordás JG, Llàcer P, Pomares A, Fort A, De Antonio IP, Méndez A, Bermejo ZB, Pérez PC, Gracia JR, Mayoral AR, Zegrí I, García Pinilla JM, Hernández EM, Castro A, Soler MJ, Górriz JL, Claret RB, Brugués PF, Manzano L, Núñez J

Prevalence and clinical profile of kidney disease in patients with chronic heart failure. Insights from the Spanish cardiorenal registry.

REVISTA ESPANOLA DE CARDIOLOGIA, 2024, 77, 50-59 dx.doi.org/10.1016/j.rec.2023.05.003

Cardiovascular Genetics

Martínez-Moreno R, Carreras D, Sarquella-Brugada G, Pérez GJ, Selga E, Scornik FS, Brugada R

Loss of sodium current caused by a Brugada syndrome-associated variant is determined by patient-specific genetic background.

Heart Rhythm, 2024, 21, 331-339 dx.doi.org/10.1016/j.hrthm.2023.11.019

Cardiovascular Genetics

Aboal J, Pascual J, Loma-Osorio P, Nuñez M, Badosa E, Martín C, Ferrero M, Moral S, Ballesteros E, Pedraza J, Tapia S, Brugada R

Impact of a Cardiogenic Shock Program on Mortality in a Non-Transplant Hospital.

HEART LUNG AND CIRCULATION, 2024, 33, 38-45 dx.doi.org/10.1016/j.hlc.2023.11.010

Cardiovascular Genetics , Research in Vascular Health

Camps-Vilaró A, Pinsach-Abuin ML, Degano IR, Ramos R, Martí-Lluch R, Elosua R, Subirana I, Solà-Richarte C, Puigmulé M, Pérez A, Vilaró I, Cruz R, Diz-de Almeida S, Nogues X, Masclans JR, Güerri-Fernández R, Marin J, Tizon-Marcos H, Vaquerizo B, Brugada R, Marrugat J

Genetic characteristics involved in COVID-19 severity. The CARGENCORS case-control study and meta-analysis.

J MED VIROL, 2024, 96 dx.doi.org/10.1002/jmv.29404

Cardiovascular Genetics

Cazzato F, Grassi S, Brugada R, Oliva A

Letter to the editor regarding the article "Heart weight must not be measured before dissection during autopsies".

INTERNATIONAL JOURNAL OF LEGAL MEDICINE, 2024 dx.doi.org/10.1007/s00414-024-03189-0

Cardiovascular Genetics

Biener L, Vogelhuber J, Alboany H, Tiyerili V, Weber M, Linhart M, Becher MU, Schenk A, Nickenig G, Skowasch D, Pizarro C

Prevalence of sleep-disordered breathing in patients with mitral regurgitation and the effect of mitral valve repair

SLEEP AND BREATHING, 2023, 27, 599-610 dx.doi.org/10.1007/s11325-022-02667-2

Neurodegeneration and Neuroinflammation , Cardiovascular Genetics

Muñoz-San Martín M, Gómez I, Quiroga-Varela A, Gonzalez-Del Río M, Robles Cedeño R, Álvarez G, Buxó M, Miguela A, Villar LM, Castillo-Villalba J, Casanova B, Quintana E, Ramió-Torrentà L

miRNA Signature in CSF From Patients With Primary Progressive Multiple Sclerosis.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION, 2023, 10 dx.doi.org/10.1212/NXI.0000000000200069

Cardiovascular Genetics

Martinez-Barrios E, Sarquella-Brugada G, Perez-Serra A, Fernandez-Falgueras A, Cesar S, Alcalde M, Coll M, Puigmulé M, Iglesias A, Ferrer-Costa C, Del Olmo B, Picó F, Lopez L, Fiol V, Cruzalegui J, Hernandez C, Arbelo E, Díez-Escuté N, Cerralbo P, Grassi S, Oliva A, Toro R, Brugada J, Brugada R, Campuzano O

Reevaluation of ambiguous genetic variants in sudden unexplained deaths of a young cohort.

INTERNATIONAL JOURNAL OF LEGAL MEDICINE, 2023, 137, 345-351 dx.doi.org/10.1007/s00414-023-02951-0

Cardiovascular Genetics

Moral S, Abulí M, Méndez I, González-Gómez A, García-Quintana A, Menduiña I, Payá R, Esteban E, Sánchez PL, Díaz E, de la Morena G, Calvo-Iglesias F, Gallego P, Ballesteros E, Brugada R, Evangelista A

Invasive management of significant tricuspid regurgitation in clinical practice.

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2023, 375, 66-73 dx.doi.org/10.1016/j.ijcard.2023.01.005

Cardiovascular Genetics

Vallverdú-Prats M, Carreras D, Pérez GJ, Campuzano O, Brugada R, Alcalde M

Alterations in Calcium Handling Are a Common Feature in an Arrhythmogenic Cardiomyopathy Cell Model Triggered by Desmosome Genes Loss.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 dx.doi.org/10.3390/ijms24032109

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Competitive projects

Cardiovascular Genetics

Estudio de expresión del ARN en pacientes con miocardiopatía arritmogénica para la determinación del sustrato fisiopatológico inductor de arritmias

Codi oficial: SEC/FEC-INV-BAS 20/003 Start date:28/10/2020 Data fi: 31/12/2024 Investigador/a principal: OSCAR CAMPUZANO LARREA, RAMON BRUGADA TERRADELLAS Organisme finançador: SOCIEDAD ESPAÑOLA DE CARDIOLOGIA

Cardiovascular Genetics

Mendelian Randomization to assess causal genetic pathways leading to severe COVID-19 (GINA-COVID)

Codi oficial: GINA-COVID Start date:20/07/2021 Data fi: 30/07/2024 Investigador/a principal: RAMON BRUGADA TERRADELLAS Organisme finançador: FUNDACIO LA MARATO TV3

Cardiovascular Genetics

Data-driven cancer genome interpretation for personalised cancer treatment

Codi oficial: 101057509 Start date:01/11/2022 Data fi: 31/10/2027 Investigador/a principal: JOAN BRUNET VIDAL, RAMON BRUGADA TERRADELLAS, RAMON BRUGADA TERRADELLAS Organisme finançador: EUROPEAN COMISSION

Cardiovascular Genetics

Programa de prevenció de malalties cardiovasculars basat en el cribatge d'arteriopatia perifèrica asimptomàtica. (Health origram for prevention of cardiovascular diseases based on a risk screeNing strategy with Ankle-brachial index).

Codi oficial: SLT021/21/000015 Start date:01/04/2022 Data fi: 31/12/2024 Investigador/a principal: RAMON BRUGADA TERRADELLAS Organisme finançador: GENERALITAT DE CATALUNYA

Cardiovascular Genetics

Variabilidad fenotípica en la Miocardiopatía Arritmogénica: De los mecanismos moleculares a la práctica clínica

Codi oficial: PI22/00422 Start date:01/01/2023 Data fi: 31/12/2025 Investigador/a principal: RAMON BRUGADA TERRADELLAS, MIREIA ALCALDE MASEGÚ Organisme finançador: INSTITUTO DE SALUD CARLOS III

Cardiovascular Genetics

Ajuts per donar suport a les activitats dels grups de recerca de Catalunya (SGR-Cat 2021) - Genètica Cardiovascular (Gencardio)

Codi oficial: SGR-Cat 2021 - Genètica Cardiovascular (Gencardio) Start date:01/01/2022 Data fi: 30/06/2025 Investigador/a principal: RAMON BRUGADA TERRADELLAS Organisme finançador: AGENCIA DE GESTIO D'AJUTS UNIV. I RECER.

Cardiovascular Genetics

Implementció de la segona fase del programa Pm05 "Girona, territori cardioprotegit" - Isabel Ramió / Manjhot

Codi oficial: Girona, territori cardioprotegit Start date:01/07/2022 Data fi: 31/10/2025 Investigador/a principal: RAMON BRUGADA TERRADELLAS Organisme finançador: DIPUTACIO DE GIRONA

Cardiovascular Genetics

Ajuda de personal Suport als grups PERIS - Genètica Cardiovascular

Codi oficial: SLT028/23/000317 Start date:01/08/2023 Data fi: 31/12/2025 Investigador/a principal: RAMON BRUGADA TERRADELLAS Organisme finançador: GENERALITAT DE CATALUNYA

Cardiovascular Genetics

Estudio prospectivo, aleatorizado, multicéntrico, abierto, guiado por eventos, para evaluar la no inferioridad de una estrategia personalizada de precisión para la prevención de la muerte súbita en pacientes con miocardiopatía dilatada no isquémica

Codi oficial: Estudi CIBER-SPANISH I Start date:15/01/2024 Data fi: 15/05/2028 Investigador/a principal: RAMON BRUGADA TERRADELLAS

Cardiovascular Genetics

Ayuda de personal PFIS

Codi oficial: FI23/00047 Start date:01/01/2024 Data fi: 31/12/2027 Investigador/a principal: ESTEL ARTIGAS MELEIRO Organisme finançador: INSTITUTO DE SALUD CARLOS III

Cardiovascular Genetics

Reducción de descargas mediante ráfagas múltiples de estimulación antitaquicardia para taquicardias ventriculares rápidas en portadores de desfibrilador automático implantable

Codi oficial: PI21/00857 Start date:01/01/2022 Data fi: 31/12/2024 Investigador/a principal: MARIA-EMILCE TRUCCO

Cardiovascular Genetics

AI Scalable Solution for ST Myocardial Infarction

Codi oficial: 230193 Start date:01/07/2023 Data fi: 30/06/2025 Investigador/a principal: JAIME ABOAL VIÑAS Organisme finançador: EUROPEAN COMISSION

Cardiovascular Genetics

Projecte ODISEA (myocardial infarction transfer safety): software desenvolupat per millorar el procés assistencial de l'infart agut de miocardi.

Codi oficial: 2023_IDIBELL_JAV Start date:11/12/2023 Data fi: 11/12/2024 Investigador/a principal: JAIME ABOAL VIÑAS Organisme finançador: PROMCAT ALTERNATIVA SL

Cardiovascular Genetics

ODISEA

Codi oficial: 2023_I3PT_JAV Start date:26/01/2024 Data fi: 31/12/2024 Investigador/a principal: JAIME ABOAL VIÑAS Organisme finançador: FUNDACIÓN INSTITUTO DE INVESTIGACIÓN E INNOVACIÓN PARC TAULÍ

Cardiovascular Genetics

ODISEA

Codi oficial: 2023_FENIN_JAV Start date:16/05/2023 Data fi: 16/05/2024 Investigador/a principal: JAIME ABOAL VIÑAS Organisme finançador: FEDERACIÓN DE EMPRESAS DE TECNOLOGÍA SANITARIA

Cardiovascular Genetics

Impacto de un programa estructurado de ejercicio físico y control de factores de riesgo cardiovasculares en prevención primaria de cardiotoxicidad en pacientes con cáncer de mama sometidos a tratamientos cardiotóxicos: Estudio PREV

Codi oficial: Estudio PREV Start date:01/11/2021 Data fi: 31/12/2025 Investigador/a principal: ARANTXA ERASO URIÉN, SERGI MORAL TORRES Organisme finançador: FUNDACION MERCK SALUD

Job offers

Prevalence and clinical profile of kidney disease in patients with chronic heart failure. Insights from the Spanish cardiorenal registry.

Loss of sodium current caused by a Brugada syndrome-associated variant is determined by patient-specific genetic background.

Impact of a Cardiogenic Shock Program on Mortality in a Non-Transplant Hospital.

Genetic characteristics involved in COVID-19 severity. The CARGENCORS case-control study and meta-analysis.

Letter to the editor regarding the article "Heart weight must not be measured before dissection during autopsies".

Prevalence of sleep-disordered breathing in patients with mitral regurgitation and the effect of mitral valve repair

miRNA Signature in CSF From Patients With Primary Progressive Multiple Sclerosis.

Reevaluation of ambiguous genetic variants in sudden unexplained deaths of a young cohort.

Invasive management of significant tricuspid regurgitation in clinical practice.

Alterations in Calcium Handling Are a Common Feature in an Arrhythmogenic Cardiomyopathy Cell Model Triggered by Desmosome Genes Loss.

Team

Group leader - R4

Established researchers - R3

Postdoctorals researchers – R2

Predoctorals researchers – R1

Collaborators

Non-scientific research support staff

Research technicians

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