Next Monday 27/03/2023 at 15:00 h, will take place the reading of the doctoral thesis entitled: "Clinical epidemiology and molecular biology of cutaneous and mucosal melanoma in Girona 1994-2018", presented by Mrs. Anna Carbó and directed by Dr. Jordi Rubió and Dr. Rafael Marcos-Gragera.
The reading of the thesis will take place in the Hall of Degrees of the Faculty of Medicine of the University of Girona (4th floor).
This doctoral thesis analyzes the epidemiology of cutaneous and mucosal melanoma, as well as its molecular profile in order to provide new knowledge on a population basis in the province of Girona. The Girona cancer registry has been used as a source of cases. Incidence and overall and relative survival at 5 and 10 years are described, as well as a molecular analysis of the BRAF gene in cutaneous melanoma and a genetic panel in mucosal melanoma. In addition, medical evidence is provided on the treatment of patients in daily clinical practice. The 5-year overall survival for all stages in cutaneous melanomas is 81% similar to the other published studies with a prevalence of BRAF gene mutations of 50% and stage being the only statistically significant prognostic factor for survival. The overall survival at 5 years for all stages in mucosal melanomas is 21% similar also in the other published studies with a molecular profile where NRAS and NF1 mutations dominate. It is confirmed that the epidemiological characteristics of Girona are similar to those of neighboring regions, that the stage remains the most important prognostic factor for survival as well as the mutational status in the BRAF gene is not. And it is demonstrated that mucosal melanomas, apart from having a different mutational profile, have a clearly worse prognosis.