Francis de Zegher

Name:
Francis de Zegher
Sign: Francis de Zegher
Position:
Col·laboradors
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Línia principal de recerca:

Identificació de marcadors metabòlics i genètics associats a alteracions metabòliques de l'embaràs i de la descendència, i la seva relació amb el creixament pre i postnatal.

 

Línies específiques de recerca

Alteracions del desenvolupament prenatal: obesitat gestacional i restricció de creixement fetal.

Catalan

Identification of pregnancy-associated microRNAs in placenta and maternal plasma and their relationship whit fetal growth and metabolic paràmetres (CP12/03239)

Finançat per: Instituto de Salud Carlos III

Durada: des de 2013 fins a 2017

Investigador responsable: Judit Bassols Casadevall

 

Identificación de microRNAs en sangre de cordón asociados al crecimiento recuperador postnatal tras restricción fetal. Modulación del crecimiento recuperador por metformina (PI14/01625)

Finançat per: Instituto de Salud Carlos III

Durada: des de 2015 fins a 2017

Investigador responsable: Judit Bassols Casadevall

 

Perfil desfavorale d'àcids grassos en placenta i epigenètica del desenvolupament

Finançat per: Societat Catalana d'Endocrinologia i Nutrició (SCEN)

Durada: des de 2016 fins a 2017

Investigador responsable: Judit Bassols Casadevall

 

 

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Placental Sprouty 2 (SPRY2): Relation to Placental Growth and Maternal Metabolic Status

Placental Sprouty 2 (SPRY2): Relation to Placental Growth and Maternal Metabolic Status

BACKGROUND: SPROUTY2 (SPRY2) is a membrane-associated protein expressed by placental macrophages with regulatory roles in tissue growth and development. The SPRY2 locus was shown to be associated with body fat distribution and susceptibility to type 2 diabetes. OBJECTIVES: We assessed whether SPRY2 mRNA levels are related with maternal metabolic status and with placental weight. We also studied the association of placental mRNA of SPRY2 with macrophage-derived inflammatory genes.

Undefined
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Balanced Duo of Anti-Inflammatory SFRP5 and Pro-Inflammatory WNT5A in Children.

Balanced Duo of Anti-Inflammatory SFRP5 and Pro-Inflammatory WNT5A in Children.

Background:Secreted frizzled-related protein 5 (SFRP5) is an adipokine protecting against obesity-related insulin resistance and diabetes. SFRP5 binds to wingless type MMTV integration site family member 5A (WNT5A) to improve insulin sensitivity. We performed a first study of SFRP5 and WNT5A in children.Methods:Prepubertal children (n=342) were assessed for circulating SFRP5 (all subjects) and circulating WNT5A (210 subjects), and associations were sought with metabolic markers.

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