Chromosome Replication

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Strategic objectives and main line of research

     DNA replication is an essential task to any living organism. In eukaryotes, multiple replication origins are used to replicated their large genomes. To achieve that any given origin is activated only once per cell cycle, the activation of the replicative helicase has been partitioned in two mutually exclusive steps along the cell cycle. During G1, origins are licensed and upon entry into S-phase, the licensed origins are activated. This activation allows the assembly of the replisome and DNA synthesis starts. Ultimately, two replisomes will converge and be disassembled under normal termination. Our goal is to understand at mechanistic level, the assembly and disassembly of the helicase, and how it is regulated by the cell. 

 

Research projects

-   Mechanistic studies on the helicase assembly and its cellular regulation.

-   Identify new helicase domains involved in its disassembly.

-   Explore new therapies involving inhibition of the helicase assembly

 

 

Responsable: 
Geoposicio: 

Estudios bioquímicos de la finalización de la replicación cromosómica. Disección molecular del desensamblaje del replisoma en condiciones normales y de estrés replicativo
Finançador: Ministerio de Economica y Competitividad
Codi: BFU2016-79927-P. Investigador principal: Jordi Frigola Mas

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